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| 1 | Metoprolol com- pared to carvedilol deteriorates insulin-stimulated endothelial function in patients with type 2 diabetes-a randomized study显示文摘 | Kveiborg R Hermann TS Major-Pedersen A | 2010 | Cardiovas Diabe- tol2010，9，： | 1 |
| 2 | Decomposing the Decoupling of Danish Road Freight Traffic Growth and Economic Growth 显示文摘 | KVEIBORG O FOSGERAU M | 2007 | Transport Policy2007，，14： | 1 |
| 3 | Production and action of transforming growth factor beta in human osteoblast cultures: dependence on cell differentiation and modulation by ealcitriol 显示文摘 | Kassem M Kveiborg M Eriksen EF | 2000 | Eur J ClinInvest2000，30，5： | 1 |
| 4 | ADAM12 is a costimulatory molecule that determines Th1 cell fate and mediates tissue inflammation显示文摘A disintegrin and metalloproteinase(ADAM)12 was previously found to be expressed in T cells in the inflamed brain.However,the function of ADAM12 in T-cell responses in general and in tissue inflammation has not been examined.Here,we studied the role of ADAM12 in T-cell responses,fate determination on activation,and its functions in T cells to mediate tissue inflammation.We identified ADAM12 as a costimulatory molecule that is expressed on naive T cells and downregulated on stimulation.ADAM12 mimics CD28 costimulatory signaling to activate and induce the proliferation of T-helper 1(Th1)cells.Monoclonal ADAM12 Fab antibodies trigger T-cell activation by amplifying TCR signaling to stimulate T-bet-mediated IFNγproduction.Lack of genomic ADAM12 and its knockdown in T cells diminished T-bet and IFNγproduction in Th1 cells,whereas other T cells,including Th17 cells,were unaffected.ADAM12 had similar functions in vivo on myelin antigen(MOG_(35-55))-induced T-cell activation.We found that genetic loss of ADAM12 profoundly alleviated Th1-mediated neuroinflammation and thus disease severity in experimental autoimmune encephalomyelitis,a model of multiple sclerosis.Transcriptomic profiling of MOG_(35-55)-specific ADAM12^(−/−)T cells revealed differentially expressed genes that are important for T-cell activation,proliferation,and costimulatory signaling and Th1 pathogenicity,consistent with their inability to cause T-cell-mediated skin inflammation in a model of adoptive delayed-type hypersensitivity.We conclude that ADAM12 is a T-cell costimulatory molecule that contributes to the pathogenesis of tissue inflammation and a potential target for the treatment of Th1-mediated diseases. | Yawei Liu Robert Bockermann Mahdieh Hadi Iman Safari Belinda Carrion Marie Kveiborg Shohreh Issazadeh-Navikas | 2021 | Cellular & Molecular Immunology2021，18，8： | 1 |
| 5 | Decomposing the decoupling of Danish road freight traffic growth and economic growth显示文摘 | KVEIBORG O | 2007 | Transport Policy2007，14，1： | 1 |
| 6 | Cloning I I and identification of genes that associate with mammalian replicative senescence显示文摘 | GONOS ES DERVENTZI A KVEIBORG M | 1998 | Exp Cell Res1998，240，1： | 1 |
| 7 | 1,25-Dihydroxyvitamin D3stimulates the production of insulin-like growth factorbinding proteins-2,-3and-4in human bone marrow stromal cells显示文摘 | Kveiborg M Flyvbjerg A Eriksen E F | 2001 | Eur J Endocrinol2001，144，5： | 1 |
| 8 | ADAM12 induces actin cytoskeleton and extracel ular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function显示文摘 | Kawaguchi N Sundberg C Kveiborg M | | 0，，19： | 1 |
| 9 | Production and action of transforming growth factor- beta in human osteoblast cultures: dependence on cell differentiation and modulation by calciriol显示文摘 | Kassem M Kveiborg M Eriksen EF | 2000 | EurJ Clin Invest2000，30，5： | 1 |
| 10 | Trans- forming growth factor betal stimulates the produc- tion of insulin-like growth factor-I and insulin-like growth factor-bingding protein-3in human bone mar- row stromal osteoblast progenitors 显示文摘 | Kveiborg M Flyvbjerg A Eriksen EF | 2001 | Endocrinol2001，169，3： | 1 |
| 11 | Metabolic effects of beta-adrenoceptor antagonists with special emphasis on carvedilol 显示文摘 | Kveiborg B Christiansen B Major-Pctersen A | 2006 | Am J Cardiovasc Dings2006，6，4： | 1 |
| 12 | The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth,HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines显示文摘 | Tove Kirkegaard Christina Yde Marie Kveiborg Anne Lykkesfeldt | 2014 | International Journal of Oncology2014，，1： | 1 |
| 13 | Metabolic effects of beta-adrenocept or ant agonists with special emphasis on carvedilol显示文摘 | Kveiborg B Christiansen B Major-Petersen A | 2006 | Am J Cardiovasc Drugs2006，6，4： | 1 |
| 14 | Metabolic effects of beta- adrenoceptor antagonists with special emphasis on carvedilol 显示文摘 | Kveiborg B Christiansen B Major- Petersen A | 2006 | Am J Cardiovasc Drugs2006，6，： | 1 |
| 15 | Treatment with 1,25 - Dihydroxyvi - tamin D3 reduces impairment of human osteoblast functions during cellular aging in culture 显示文摘 | Kveiborg M BaUan SI Clark BF et el | 2001 | J Cell Physiol2001，186，2： | 1 |
| 16 | Cloning and identification of genes that associate with mammalian replieativc senescence显示文摘 | Gonos ES Derventzi A Kveiborg M | 1998 | Exp Cell Res1998，240，1： | 1 |
| 17 | Decomposing the Decoupling of Dartish Road Freight Traffic Growth and Economic Growth显示文摘 | KVEIBORG O POSGERAU M | 2007 | Transport Policy2007，，14： | 1 |
| 18 | Treatment with 1,25-dihydroxyvitamin D3 reduces impairment of human osteoblast functions during cellular aging in culture显示文摘 | Rattan SI Clark BF | 2001 | J Cell Physiol2001，186，2： | 1 |
| 19 | Metabolic effects of beta-adrenoceptor antagonists with special emphasis on carvedilol显示文摘 | Kveiborg B Christiansen B Major-Petersen A | 2006 | Am J Cardiovasc Drugs2006，6，4： | 1 |
| 20 | Decomposing the decoupling of Danish road freight traffic growth and economic growth显示文摘 | Kveiborg O Fosgeran M | 2007 | Transport Policy2007，14，1： | 1 |
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