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| 1 | 2,3-Diaryl-3H-imidazo[4,5-b]pyridine derivatives as potential anticancer and anti-inflammatory agents显示文摘In this study we examined the suitability of the 3H-imidazo[4,5-b]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3H-imidazo[4,5-b]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity in vitro. The results showed that compound 3f exhibited 2-fold selectivity with IC_(50) values of 9.2 and 21.8 mmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compound 3f revealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme. | Erin Marie Kirwen Tarun Batra Chandrabose Karthikeyan Girdhar Singh Deora Vandana Rathore Chaitanya Mulakayala Naveen Mulakayala Amy Catherine Nusbaum Joel Chen Haneen Amawi Kyle Mc Intosh Sahabjada Neelam Shivnath Deepak Chowarsia Nisha Sharma Md Arshad Piyush Trivedi Amit KTiwari | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 3 |
| 2 | Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity显示文摘 | Ross M. Wilkins MD John W. Cullen MD Lorrie Odom MD Brandt A. Jamroz MD Patsy McGuire Cullen MS CPNP Kyle Fink MD Sanford D. Peck MD Sydney L. Stevens MD Cynthia M. Kelly MD Anne B. Camozzi BA | 2003 | Annals of Surgical Oncology2003，，5： | 1 |
| 3 | Sequence of testing for monoclonal gammo-pothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 4 | Sequence of testing for monoclonal gammopothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 5 | Breast and cervical cancer in 187 countries between 1980 and 2010: a sys- tematic analysis 显示文摘 | Mohammad H Forouzanfar MD a Kyle J Foreman MPH a Allyne M Delossantos BS a | 2011 | The Lancet2011，378，9801： | 1 |
| 6 | Superior Survival in Treatment of Primary Nonmetastatic Pediatric Osteosarcoma of the Extremity显示文摘 | Ross M. Wilkins MD John W. Cullen MD Lorrie Odom MD Brandt A. Jamroz MD Patsy McGuire Cullen MS CPNP Kyle Fink MD Sanford D. Peck MD Sydney L. Stevens MD Cynthia M. Kelly MD Anne B. Camozzi BA | 2003 | Annals of Surgical Oncology2003，，5： | 1 |
| 7 | Sequence of testing for monoclonal gammopothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 8 | Corneal endothelial cell changes 5years after laser in situ keratomileusis:Femtosecond laser versus mechanical microkeratome显示文摘 | Kyle N Klingler MD Jay W | 2012 | Cataract Retract Surg2012，38，9： | 1 |
| 9 | Sequence of testing for monoclonal gammopothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，11： | 1 |
| 10 | Sequence of testing for monoclonal gammopothies serum and urine assays 显示文摘 | Robert A Kyle MD | 1999 | Arch pathol Lab Med1999，123，2： | 1 |
| 11 | Sequence of testing for monoelonal galn - mopothies serum and urine assays显示文摘 | Robert A Kyle MD | 1999 | Arch Pathol Lab Med1999，123，2： | 1 |
| 12 | Accelerated partial breast inten- sity modulated radiotherapy results in improved dose distribution when compared with three - dimensional treatment planning technique 显示文摘 | Kyle E Rusthoven MD Dennis L | 2008 | Int J Radia Oncol Biol Phys2008，70，： | 1 |
| 13 | Patient and caregiver characteristics associated with depression in caregivers of patients with dementia显示文摘 | Dr. Kenneth E. Covinsky MD MPH Robert Newcomer PhD Patrick Fox PhD Joan Wood PhD Laura Sands PhD Kyle Dane BS Kristine Yaffe MD | 2003 | Journal of General Internal Medicine2003，，12： | 1 |
| 14 | Get Moving-Physical Activity Is Good for Your Health显示文摘Regular, Moderate physical activity can help prevent *a multitude of1 health problems. It protects against heart disease and favorably *modifies other cardiovascular risk factors2 such as obesity3 and overweight, high cholesterol4, high blood pressure, and *adult-onset diabetes5.Physical activity is also important in the treatment of individuals who have developed cardiovascular disease- | Kyle J.Mclnnis ScD James M.Rippe MD 李小平 | 2002 | 语言教育2002，，3： | 0 |
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