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| 1 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 2 | Readers of histone modifications显示文摘在调整染色质的重要角色组织的不仅玩和原子过程而且罐头作为 epigenetic 标记被传递给女儿房间的 Histone 修正。积累的证据建议 histone 修正的关键函数是为下游的受动器的招募或活动发信号。这里,我们讨论 histone 修正读者的最近的发现并且修正语言怎么被解释。 | Miyong Yun Jun Wu Jerry L Workman Bing Li | 2011 | Cell Research2011，21，4： | 21 |
| 3 | Pollen-inferred Holocene vegetation and climate histories in Taro Co,southwestern Tibetan Plateau显示文摘A 310-cm-long sediment core,covering the last10,200 years,was collected from Taro Co on the southwestern Tibetan Plateau and analyzed for pollen,grain size and total inorganic carbon content.The pollen data showed that vegetation changed from alpine steppe to alpine meadow during 10,200–8,900 cal a BP,to alpine steppe dominated by Artemisia during 8,900–7,400 cal a BP,to alpine meadow during 7,400–3,300 cal a BP and to alpine steppe after 3,300 cal a BP.Correspondingly,the pollen,grain size and total inorganic carbon content results revealed climatic change in this area over four stages.The initial stage was from 10,200 to 8,900 cal a BP,during which the climate changed from cold-dry to warm-humid.The second stage(8,900–7,400 cal a BP)was characterized by a warm and dry climate.However,at approximately7,400 cal a BP,the climate began to become cold and humid,which continued until 3,300 cal a BP.The last stage,from 3,300 cal a BP to present,was characterized as cold and increasingly arid.Climatic events of the early and mid-late Holocene showed that the area was significantly affected by the westerlies.However,the mid-Holocene climate in Taro Co was controlled by the Indian monsoon.The mid-late Holocene depositional environment record of Taro Co was very important to further elaborate the degree of influence by the westerlies or Indian monsoon. | Qingfeng Ma Liping Zhu Xinmiao L Yun Guo Jianting Ju Junbo Wang Yong Wang Lingyu Tang | 2014 | Chinese Science Bulletin2014，59，31： | 7 |
| 4 | Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor:a single-blinded,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIPN), quality of life and immune status of patients with malignant tumors.METHODS:From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy.The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment.Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment.Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.RESULTS:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all P >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, P = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, P =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, P < 0.001).The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, P < 0.001).Both electroacupuncture and acupuncture had no effects on immune function.CONCLUSION:Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. | Zhang Shiqiang Wu Tingting Zhang Haisheng Yang Yun Jiang Haiyan Cao Shengcheng Xie Fang Xia Xiaoting Lü Junqiang Zhong Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 7 |
| 5 | Tumor infiltrating lymphocytes in triple negative breast cancer receiving neoadjuvant chemotherapy显示文摘AIM To determine influence of neoadjuvant-chemotherapy(NAC) over tumor-infiltrating-lymphocytes(TIL) intriple-negative-breast-cancer(TNBC).METHODS TILs were evaluated in 98 TNBC cases who came to Instituto Nacional de Enfermedades Neoplasicas from 2005 to 2010. Immunohistochemistry staining for CD3, CD4, CD8 and FOXP3 was performed in tissue microarrays(TMA) sections. Evaluation of H/E in full-face and immunohistochemistry in TMA sections was performed in pre and post-NAC samples. STATA software was used and P value < 0.05 was considered statistically significant. RESULTS Higher TIL evaluated in full-face sections from pre-NAC tumors was associated to pathologic-complete-response(pCR)(P = 0.0251) and outcome(P = 0.0334). TIL evaluated in TMA sections showed low level of agreement with full-face sections(ICC = 0.017-0.20) and was not associated to pCR or outcome. TIL in post-NAC samples were not associated to response or outcome. PostNAC lesions with pC R had similar TIL levels than those without pCR(P = 0.6331). NAC produced a TIL decrease in full-face sections(P < 0.0001). Percentage of TIL subpopulations was correlated with their absolute counts. Higher counts of CD3, CD4, CD8 and FOXP3 in pre-NAC samples had longer disease-free-survival(DFS). Higher counts of CD3 in pre-NAC samples had longer overallsurvival. Higher ratio of CD8/CD4 counts in pre-NAC was associated with pCR. Higher ratio of CD4/FOXP3 counts in pre-NAC was associated with longer DFS. Higher counts of CD4 in post-NAC samples were associated with pCR.CONCLUSION TIL in pre-NAC full-face sections in TNBC are correlated to longer survival. TIL in full-face differ from TMA sections, absolute count and percentage analysis of TIL subpopulation closely related. | Carlos A Castaneda Elizabeth Mittendorf Sandro Casavilca Yun Wu Miluska Castillo Patricia Arboleda Teresa Nunez Henry Guerra Carlos Barrionuevo Ketty Dolores-Cerna Carolina Belmar-Lopez Julio Abugattas Gabriela Calderon Miguel De La Cruz Manuel Cotrina Jorge Dunstan Henry L Gomez Tatiana Vidaurre | 2016 | World Journal of Clinical Oncology2016，7，5： | 6 |
| 6 | Phase Ⅱ trial of gemcitabine plus cisplatin in patients with advanced non-small cell lung cancer显示文摘 | Yun FAN Neng-ming LIN Sheng-lin MA Lü-hong LUO Luo FANG Zhi-yu HUANG Hai-feng YU Feng-qin WU | 2010 | Acta Pharmacologica Sinica2010，31，6： | 6 |
| 7 | 经皮经导管射频消融去肾交感神经术与螺内酯对难治性高血压昼夜节律和血压变异性的影响显示文摘经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析, | de la Sierra A Pareja J Armario P Barrera Yun S Vázquez S Sans L Pascual J Oliveras A 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 8 | Autophagy as new emerging cellular effect of nanomaterials显示文摘The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and application.In the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials,most emphasis were placed on processes such as apoptosis,metabolic inhibition and oxidative stress.Recent evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic process.This review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related diseases.We summarize current research status of interaction between nanomaterials and autophagic pathways.It is of note that nanomaterials can either induce or block autophagy,which result in similar phenotype but completely different biological consequence.It is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research. | ZHONG WenYing Lü Min LIU LiYing SUN JinLi ZHONG ZengTao ZHAO Yun SONG HaiYun | 2013 | Chinese Science Bulletin2013，58，33： | 3 |
| 9 | Red meat intake and the risk of endometrial cancer:Metaanalysis of observational studies显示文摘AIM:To evaluate whether red meat intake is related to the risk of endometrial cancer(EC) using meta-analysis.METHODS:We searched Pub Med,EMBASE,and the Cochrane Library up to June 2013,using common keywords related to red meat and EC.Case-control studies and cohort studies comparing the risk of endometrial cancer among categories by the amount of intake were included.Eleven case-control studies and five cohort studies met our criteria.We performed a conventional and a dose-response meta-analysis of case-control studies using the Der Simonian-Laird method for random-effects.For cohort studies we performed a conventional meta-analysis.Publication bias was evaluated using Egger's test.RESULTS:In the meta-analysis of 11 case-control studies including 5419 cases and 12654 controls,higher red meat consumption was associated with an increased risk of EC [summary relative risk(SRR) = 1.43,95%CI:1.15-1.79;I2 = 73.3% comparing extreme intake categories).In a dose-response analysis,for red meat intake of 100 g/d,SRR was 1.84(95%CI:1.64-2.05).In contrast,in the meta-analysis of five prospective studies including a total of 2549 cases among 247746 participants,no significant association between red meat intake and EC risk(SRR = 0.97,95%CI:0.85-1.11;I2 = 4.9% comparing extreme intake categories) was observed.CONCLUSION:Our meta-analysis found a significantlinear association between red meat intake and EC risk based on case-control studies but this was not confirmed in prospective studies. | Woong Ju Na Na Keum Dong Hoon Lee Yun Hwan Kim Seung Cheol Kim Eric L Ding Eunyoung Cho | 2015 | World Journal of Meta-Analysis2015，3，2： | 2 |
| 10 | A new glycoside, brachynoside, isolated from Clerodendron brachyanthum Schauer 显示文摘 | Yun L L Yueh H | 1992 | Chem Pharm Bull1992，40，7： | 2 |
| 11 | Output characteristics of square and circular resonator microlasers connected with two output waveguides显示文摘Square and circular resonator microlasers connected with two output waveguides are investigated for correlation of output powers from the two output ports.The square resonator microlasers with two output waveguides connected at the midpoint of one side and one vertex are fabricated and tested by measuring the output power versus injection current and the laser spectra of the two ports.The laser spectra indicated that the output power correlation between the two output ports is very weak because of different lasing modes in different ports of the square microlaser.Circular resonator microlaser with two output waveguides can realize single mode operation and has good output correlation from the two ports.So the output power from one port of the circular microlasers can be monitored by that of another port. | HUANG YongZhen Lü XiaoMeng LIN JianDong DU Yun | 2013 | Chinese Science Bulletin2013，58，7： | 2 |
| 12 | Brillouin scattering spectrum for liquid detection and applications in oceanography显示文摘The Brillouin scattering spectrum has been used to investigate the properties of a liquid medium.Here,we propose an improved method based on the double-edge technique to obtain the Brillouin spectrum of a liquid.We calculated the transmission ratios and deduced the Brillouin shift and linewidth to construct the Brillouin spectrum by extracting the Brillouin edge signal through filtered double-edge data.We built a detection system to test the performance of this method and measured the Brillouin spectrum for distilled water at different temperatures and compared it with the theoretical prediction.The observed difference between the experimental and theoretical values for Brillouin shift and linewidth is less than 4.3 MHz and 3.2 MHz,respectively.Moreover,based on the double-edge technique,the accuracy of the extracted temperatures and salinity is approximately 0.1°C and 0.5‰,respectively,indicating significant potential for application in water detection and oceanography. | Yuanqing Wang Jinghao Zhang Yongchao Zheng Yangrui Xu Jiaqi Xu Jiao Jiao Yun Su Hai-Feng Lü Kun Liang | 2023 | Opto-Electronic Advances2023，6，1： | 2 |
| 13 | Current Status and Prospect of Stent Placement for May-Thurner Syndrome显示文摘Stent implantation has been proven to be safe and has become the first-line intervention for May-Thumer syndrome(MTS),with satisfactory mid-term patency rates and clinical outcomes.Recent research has demonstrated that catheter-directed thrombolysis is the preferred strategy when MTS is combined with deep vein thrombosis after self-expanding stent placement.However,the stent used for the venous system was developed based on the experience obtained in the treatment of arterial disease.Consequently,relatively common corresponding complications may come along later,which include stent displacement,deformation,and obstruction.Different measures such as adopting a stent with a larger diameter,improving stent flexibility,and increasing stent strength have been employed in order to prevent these complications.The ideal venous stent is presently being evaluated and will be introduced in detail in this review. | Qin LIU Fang LIU Ping LÜ Hong-xiao WU Pin YE Yun YOU Zhong YAO | 2021 | Current Medical Science2021，41，6： | 2 |
| 14 | Improved in-situ Determination of Sr Isotope Ratio in Silicate Samples Using LA-MC-ICP-MS and Its Wider Application for Fused Rock Powder显示文摘The in-situ Sr isotope determination of solid samples has the advantages of high spatial resolution and convenient and rapid sample preparation.However,due to the lack of column chemistry separation of matrix elements from Sr,the interference correction(especially the isobaric interference from 87Rb on 87Sr)becomes a big issue for high precise in-situ Sr isotope analytical results.In this study,we evaluated the influence of isobaric interference systematically and adopted an improved strategy for isobaric interference correction of Rb.Specifically,as an external standard for data calibration,an in-house silicate standard(Rb-std)was fused from pure oxide powders.The new standard(Rb-std)shows very low contents of Sr(<1 ppm),Yb(<0.09 ppm)and Er(<0.05 ppm),which directly avoid the trouble of interference of doubly charged ions and isobar,when we determinate the mass fractionation factors of Rb(βRb).Our improved method can provide more accurate data than previous researches,in which the mass fractionation were calculated from an external reference material StHs6/80-G with high Rb(30.07 ppm),Sr(482 ppm),Yb(1.13 ppm)and Er(1.18 ppm).Then,these βRb from Rb-std were applied by linear interpolation to the unknown samples for correction of 87Rb on 87Sr.The analytical results of serial international reference materials(BIR-1G,BCR-2G,BHVO-2G,T1-G and ATHO-G)demonstrate that our improved method can raise the upper limit of Rb/Sr for in-situ Sr isotope determination and reduce the relative standard deviation of results.This improvement of the upper limit of Rb/Sr(<0.33)will expand not only range of microanalysis for silicate minerals,but also bulk Sr isotope determination of volcanic rock combining with rapid fusion technique. | Lüyun Zhu Ganglan Zhang Yongsheng Liu Jie Lin Xirun Tong Shao-Yong Jiang | 2020 | Journal of Earth Science2020，31，2： | 2 |
| 15 | Arabidopsis mitogen - activated protein kinase kinases MKK1 and MKK2 have overlapping functions in defense signaling mediated by MEKK1, MPK4, and MKS1 显示文摘 | Qiu J L Zhou L Yun B W | 2008 | Plant Physiology2008，148，1： | 1 |
| 16 | Quantitative and qualitative assessment of articular cartrilage in the goat knee with magnetization transfer imaging显示文摘 | Didier L James W Jian yun Y | 2006 | Magn Reson Imaging2006，19，10： | 1 |
| 17 | OPG/FDCR-1,a TNF receptor family member,is expressed in lymphoid cells and is up-regulated by ligating CD40显示文摘 | Yun T J Chaudhary P M Shu G L | 1998 | J Immunol1998，161，11： | 1 |
| 18 | Color image segmentation based on 3-D clustering:Morphological Approach显示文摘 | Park S H L D Yun S U Lee | 1998 | Pattern Recognition1998，31，8： | 1 |
| 19 | The fragile X mental retardationprotein binds and regulates a novel elass of mRNAs containing U rich target sequences显示文摘 | Chen L Yun S W Seto J | 2003 | Neuroseience2003，120，4： | 1 |
| 20 | Effects of salinity on germina- tion of six forage species and their recovery from saline conditions显示文摘 | Yu Y S Yun L S Guo Y | 2003 | New Zealand Journal of Agricultural Re- search2003，46，： | 1 |
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