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| 1 | Silk‐Based Conformal, Adhesive, Edible Food Sensors显示文摘 | HuTao Mark A.Brenckle MiaomiaoYang JingdiZhang MengkunLiu Sean M.Siebert Richard D.Averitt Manu S.Mannoor Michael C.McAlpine John A.Rogers David L.Kaplan Fiorenzo G.Omenetto | 2012 | Adv Mater2012，，8： | 1 |
| 2 | Metamaterial Silk Composites at Terahertz Frequencies显示文摘 | HuTao Jason J.Amsden Andrew C.Strikwerda KebinFan David L.Kaplan XinZhang Richard D.Averitt Fiorenzo G.Omenetto | 2010 | Adv Mater2010，，32： | 1 |
| 3 | Chondrogenesis in perfusion bioreactors using porous silk scaffolds and hESC‐derived MSCs显示文摘 | R. SedaT??l? ChrisCannizaro Menem?eGümü?derelio?lu David L.Kaplan | 2010 | J Biomed Mater Res2010，，1： | 1 |
| 4 | 丝蛋白复合骨形态发生蛋白2在大鼠炎性牙髓愈合中的作用显示文摘目的:探讨将丝蛋白复合骨形态发生蛋白2(bone morphogenetic protein 2,BMP-2)作为盖髓剂,治疗由脂多糖(lipopolysaccharide,LPS)引起的大鼠炎性牙髓的效果。方法:30只雄性Wistar大鼠,随机分为5组:(1)未手术正常对照组;(2)空白对照组(无盖髓剂);(3)氢氧化钙组;(4)静电纺丝丝蛋白组(简称丝蛋白组);(5)静电纺丝丝蛋白复合BMP-2组(简称丝蛋白复合BMP-2组)。将第2∽5组双侧上颌第一磨牙开髓并放置LPS,不使用盖髓剂或使用相应盖髓剂,然后封闭开髓孔。所有组于术后第3、7、14天制作石蜡切片,行HE染色及CD14免疫组织化学染色,采用image-pro plus(IPP)软件测量免疫组织化学染色的光密度(D)值。结果:HE染色结果显示丝蛋白复合BMP-2组在各盖髓组中,术后7及14 d炎性细胞分级最低,其次是氢氧化钙组及丝蛋白组,空白对照组最高;修复性牙本质形成分级的高低顺序则相反。CD14免疫组织化学染色结果显示术后3及7 d,使用盖髓剂的3个组之间D值差异无统计学意义,但均显著低于空白对照组;14 d时丝蛋白复合BMP-2组D值(0.145±0.011)显著低于空白对照(0.287±0.019)、氢氧化钙(0.170±0.017)、丝蛋白(0.175±0.018)3个组(P〈0.05)。结论:丝蛋白复合BMP-2应用于炎性牙髓的盖髓,能减轻炎症,诱导修复性牙本质的形成,提高对炎性牙髓的治疗效果。 | 余涛 姜婷 魏青梅 李宜芬 David L.Kaplan | 2015 | 北京大学学报(医学版)2015，47，5： | 1 |
| 5 | Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell–cell contact mode显示文摘 | YongzhongWang VladimirVolloch Mariya A.Pindrus Dominick J.Blasioli JingsongChen David L.Kaplan | 2007 | J Tissue Eng Regen Med2007，，1： | 1 |
| 6 | Guide to collagen characterization for biomaterial studies显示文摘 | Leah C.Abraham ErinZuena BernardoPerez‐Ramirez David L.Kaplan | 2008 | J. Biomed. Mater. Res2008，，1： | 1 |
| 7 | Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell–cell contact mode显示文摘 | YongzhongWang VladimirVolloch Mariya A.Pindrus Dominick J.Blasioli JingsongChen David L.Kaplan | 2007 | J Tissue Eng Regen Med2007，，1： | 1 |
| 8 | Silk hydrogel for cartilage tissue engineering显示文摘 | Pen‐Hsiu GraceChao SupansaYodmuang XiaoqinWang LinSun David L.Kaplan GordanaVunjak‐Novakovic | 2010 | J Biomed Mater Res2010，，1： | 1 |
| 9 | 认识风湿热和风心病的新努力——关于链球菌和人类宿主的概念显示文摘虽然对A组β溶血性链球菌与风湿热的关系已认识半个多世纪,但对这个关系的许多重要的问题尚未完全确定。 | Edward L.Kaplan 刘小青 | 2001 | 岭南心血管病杂志2001，7，6： | 0 |
| 10 | Study the lipidoid nanoparticle mediated genome editing protein delivery using 3D intestinal tissue model显示文摘Lipid nanoparticles are promising carriers for oral drug delivery.For bioactive cargos with intracellular targets,e.g.gene-editing proteins,it is essential for the cargo and carrier to remain complexed after crossing the epithelial layer of intestine in order for the delivery system to transport the cargos inside targeted cells.However,limited studies have been conducted to verify the integrity of cargo/carrier nanocomplexes and their capability in facilitating cargo delivery intracellularly after the nanocomplex crossing the epithelial barrier.Herein,we used a traditional 2D transwell system and a recently developed 3D tissue engineered intestine model and demonstrated the synthetic lipid nanoparticle(carrier)and protein(cargo)nanocomplexes are able to cross the epithelial layer and deliver the protein cargo inside the underneath cells.We found that the EC16-63 LNP efficiently encapsulated the GFP-Cre recombinase,penetrated the intestinal monolayer cells in both the 2D cell culture and 3D tissue models through temporarily interrupting the tight junctions between epithelial layer.After transporting across the intestinal epithelia,the EC16-63 and GFP-Cre recombinase nanocomplexes can enter the underneath cells to induce gene recombination.These results suggest that the in vitro 3D intestinal tissue model is useful for identifying effective lipid nanoparticles for potential oral drug delivery. | Tao Yang Haobo Han Ying Chen Liu Yang Rachael Parker Yamin Li David L.Kaplan Qiaobing Xu | 2021 | Bioactive Materials2021，6，11： | 0 |
| 11 | 美国耐甲氧西林金黄色葡萄球菌感染治疗临床治疗指南(一)显示文摘美国感染病学会(IDSA)制订了治疗耐甲氧西林金黄色葡萄球菌(MRSA)患者的循证指南。该指南用于指导MRSA感染患者的治疗。该指南就多种与MRSA疾病相关的临床症状的治疗进行了论述,包括:皮肤和软组织感染(SSTI)、菌血症和感染性心内膜炎、肺炎、骨和关节感染、中枢神经系统(CNS)感染等。该指南重点介绍了关于万古霉素用量及监测,以及对万古霉素低敏的耐甲氧西林金黄色葡萄球菌菌株感染的治疗方案及治疗失败的处置。 | 罗明琍 吴新荣 Catherine Liu Arnold Bayer Sara E.Cosgrove Robert S.Daum Scott K.Fridkin Rachel J.Gorwitz Sheldon L.Kaplan Adolf W.Karchmer Donald P.Levine Barbara E.Murray MichaelJ.Rybak DavidA.Talan Henry F.Chambers | 2011 | 今日药学2011，21，8： | 0 |
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