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| 1 | Glycogen and amyloid-beta: key players in the shift from neuronal hyperactivity to hypoactivity observed in Alzheimer's disease?显示文摘Introduction:Alzheimer’s disease(AD)begins to develop decades prior to its clinical manifestation(Sperling et al.,2011),and while it is the most common form of dementia,as of yet there is no cure.Two of the most researched pathological features contributing to disease development are the extracellular amyloid plaques composed of amyloid-beta proteins(Aβ)and neurofibrillary tangles of tau proteins.Another feature of AD is the progression of early neuronal excitability/hyperactivity to silencing/hypoactivity(Palop and Mucke,2010),with hypoactivity explained by the synaptic failure hypothesis(Selkoe,2002).In vitro and animal model studies have demonstrated that Aβpathology associates with increased excitability | Britanny Bass Sarah Upson Kamolika Roy Emily L.Montgomery Tuula O.Jalonen Ian V.J.Murray | 2015 | Neural Regeneration Research2015，10，7： | 3 |
| 2 | Multiple outbreaks of dengue serotype 2 in north Queensland, 2003/04显示文摘 | Jeffrey N.Hanna Scott A.Ritchie Ann R.Richards Carmel T.Taylor Alyssa T.Pyke Brian L.Montgomery John P.Piispanen Anna K.Morgan Jan L.Humphreys | 2007 | Australian and New Zealand Journal of Public Health2007，，3： | 1 |
| 3 | Pharmacological applications of a novel neoepitope antibody to a modified amyloid precursor protein-derived beta-secretase product显示文摘We have previously described a novel artificial NFEVβ-secretase(BACE1)cleavage site,which when introduced into the amyloid-βprecursor protein(APP),significantly enhances APP cleavage by BACE1 in in vitro and cellular assays.In this study,we describe the identification and characterization of a single chain fragment of variable region(scFv),specific to the EV neo-epitope derived from BACE1 cleavage of the NFEV-containing peptide,and its conversion to IgG1.Both the scFv displayed on phage and EV-IgG1 show exquisite specificity for binding to the EV neoepitope without cross-reactivity to other NFEV containing peptides or WT-APP KMDA cleavage products.EV-IgG1 can detect as little as 0.3 nmol/L of the EV peptide.EV-IgG1 antibody was purified,conjugated with alkaline phosphatase and utilized in various biological assays.In the BACE1 enzymatic assay using NFEV substrate,a BACE1 inhibitor MRK-3 inhibited cleavage with an IC50 of 2.4 nmol/L with excellent reproducibility.In an APP_NFEV stable SH-SY5Y cellular assay,the EC_(50) for inhibition of EV-Aβ peptide secretion with MRK-3 was 236 nmol/L,consistent with values derived using an EV polyclonal antibody.In an APP_NFEV knock-in mouse model,both Aβ_EV40 and Aβ_EV42 peptides in brain homogenate showed excellent gene dosage dependence.In conclusion,the EV neoepitope specific monoclonal antibody is a novel reagent for BACE1 inhibitor discovery for both in vitro,cellular screening assays and in vivo biochemical studies.The methods described herein are generally applicable to novel synthetic substrates and enzyme targets to enable robust screening platforms for enzyme inhibitors. | Guoxin Wu Sethu Sankaranarayanan Donna L.Montgomery Adam J.Simon Zhiqiang An Mary J.Savage | 2011 | Protein & Cell2011，2，7： | 0 |
| 4 | 南Casper Creek油田:一个储层不均匀性研究实例显示文摘本世纪二十年代以来,南Casper Creek油田(位于怀俄明州Natrona县)风成海相沉积的Tensleep砂岩一直生产低比重的原油。直到最近,仍认为该储层是相对均匀的砂岩体,并以此对始于七十年代末,八十年代初的二次开采工作进行了模拟。由于二次开采性能较差,从而对储层进行重新评估。油田开采者,加利福尼亚联合石油公司(UNOCAL)的特征研究组,以及科罗拉多矿业学院的储层描述项目组对Tensleep储层图进行了彻底的修改。他们对有意义的地层、成岩作用和构造的不均匀性进行了识别和成图,并与先导性蒸汽驱程序下的生产率图作了相关分析。这种把地质和地球物理综合起来得到的结果是很有意义的,它关系到Tensleep层及其区域相关层系的二次开采。 | Scott L.Montgomery 许建华 | 1997 | 石油物探译丛1997，，3： | 0 |
| 5 | 堪萨斯州芬妮县斯图尔特油田薄层河道储集层的地震识别显示文摘在科罗拉多、堪萨斯、得克萨斯及俄克拉何马的部分地区,早宾夕法尼亚世(莫罗期)的河道砂体含有区域性储层。在堪萨斯州的西南部,这些储层埋深一般为4000ft~5000ft(1200m~1500m),并且每口井约有0.15Mbbl~0.2Mbbl原油的控制储量,经济效益很高。储集砂层构成了海进期河谷充填层序的一部分,该层序沉积于切入下伏密西西比纪碳酸盐岩的河道内。充填厚度最大达60ft(18m),一般为10ft~30ft(3m~9m),沿河道厚度变化剧烈。因此,精细勾绘河道走向是很困难的。位于堪萨斯州芬妮县的斯图尔特油田就是这种储集类型的典型实例。最好的储集层存在于由潮汐改造作用形成的极细—细粒河道砂岩中。由于现有的二维地震及钻井资料无助于恰当地确定河道的方位,因此早期试图使油田向东扩展的努力失败了。在注水驱油开始之前进行的三维地震调查,有助于(1)查明现存干井之间河道的位置;(2)确定钻探能够成功的远景目标区。三维地震资料的进一步外推导致了一口干井,证实本区解释的局限性。因此,斯图尔特油田提供了勘探井间远景区时三维地震资料的能力及其局限性的一个重要实例研究。 | Scott L.Montgomery 李洪革 杨学军 | 1998 | 国外油气勘探1998，10，1： | 0 |
| 6 | 瓦尔沃德盆地巴肯亥姆气田碳酸盐岩储层显示文摘最近,在得克萨斯西南部瓦尔沃德(Val Verde)盆地进行勘探的主要目的层是被冲断的宾夕法尼亚系碳酸盐岩,它们分布在欧沃其塔(Ouachita)前锋的前缘。从破裂的灰岩里产出数量可观的气和凝析油,这些灰岩沉积于不同的环境下,后来在逆掩断裂发生时呈现出复杂的并置关系。地震成像的改进,特别是采用二维线束和三维勘探能精确地成像出冲断前锋,修正了过去对盆地构造和盆地历史的解释。这些资料揭示了在不同的构造层里存在多个储层,对斯特罗恩(Strawn)储层的讨论,联系了特雷尔县(Terrell)西北巴肯亥姆(Pakenham)气田区。 | Scott L.Montgomery 唐音 | 1997 | 国外油气勘探1997，9，4： | 0 |
| 7 | 新的勘探概念突出了哥伦比亚河盆地的潜力显示文摘美国对天然气需求的不断上升以及进口前景的不确定性使得对新的国内储量的探索变得既迫切又具有经济吸引力。世界上很少有地区像美国本土48州这样虽被广泛地勘探,却仍拥有少量具有高级别探明油气潜力的新区。 | Scott L.Montgomery 谢力(译) | 2008 | 国外石油动态2008，，6： | 0 |
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