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| 1 | Baseline effects of lysophosphatidylcholine and nerve growth factor in a rat model of sciatic nerve regeneration after crush injury显示文摘Schwann cells play a major role in helping heal injured nerves. They help clear debris, produce neurotrophins, upregulate neurotrophin receptors, and form bands of Büngner to guide the healing nerve. But nerves do not always produce enough neurotrophins and neurotrophin receptors to repair themselves. Nerve growth factor(NGF) is an important neurotrophin for promoting nerve healing and lysophosphatidylcholine(LPC) has been shown to stimulate NGF receptors(NGFR). This study tested the administration of a single intraneural injection of LPC(1 mg/mL for single LPC injection and 10 mg/mL for multiple LPC injections) at day 0 and one(day 7), two(days 5 and 7), or three(days 5, 7, and 9) injections of NGF(160 ng/mL for single injections and 80 ng/mL for multiple injections) to determine baseline effects on crush ed sciatic nerves in rats. The rats were randomly divided into four groups: control, crush, crush-NGF, and crush-LPC-NGF. The healing of the nerves was measured weekly by monitoring gait; electrophysiological parameters: compound muscle action potential(CMAP) amplitudes; and morphological parameters: total fascicle areas, myelinated fiber counts, fiber densities, fiber packing, and mean g-ratio values at weeks 3 and 6. The crush, crush-NGF, and crush-LPC-NGF groups statistically differed from the control group for all six weeks for the electrophysiological parameters but only differed from the control group at week 3 for the morphological parameters. The crush, crush-NGF, and crush-LPC-NGF groups did not differ from each other over the course of the study. Single injections of LPC and NGF one week apart or multiple treatments of NGF at 5, 7 and 9 days post-injury did not alter the healing rate of the sciatic nerves during weeks 1-6 of the study. These findings are important to define the baseline effects of NGF and LPC injections, as part of a larger effort to determine the minimal dose regimen of NGF to regenerate peripheral nerves. | Ryan L.Wood Keaton S.Karlinsey Austin D.Thompson Mark N.Rigby Greggory D.Boatright William G.Pitt Beverly L.Roeder Scott C.Steffensen Alonzo D.Cook | 2018 | Neural Regeneration Research2018，13，5： | 5 |
| 2 | Town-scale microbial sewer community and H2S emissions response to common chemical and biological dosing treatments显示文摘Controlling hydrogen sulfide(H2S)odors and emissions using a single,effective treatment across a town-scale sewer network is a challenge faced by many water utilities.Implementation of a sewer diversion provided the opportunity to compare the effectiveness of magnesium hydroxide(Mg(OH)2)and two biological dosing compounds(Bioproducts A and B),with different modes of action(MOA),in a field-test across a large sewer network.Mg(OH)2 increases sewer p H allowing suppression of H2S release into the sewer environment while Bioproduct A acts to disrupt microbial communication through quorum sensing(QS),reducing biofilm integrity.Bioproduct B reduces H2S odors by scouring the sewer of fats,oils and grease(FOGs),which provide adhesion points for the microbial biofilm.Results revealed that only Mg(OH)2 altered the microbial community structure and reduced H2S emissions in a live sewer system,whilst Bioproducts A and B did not reduce H2S emissions or have an observable effect on the composition of the microbial community at the dosed site.Study results recommend in situ testing of dosing treatments before implementation across an operational system. | Elizabeth R.Mathews Jennifer L.Wood Dean Phillips Nathan Billington Dean Barnett Ashley E.Franks | 2020 | Journal of Environmental Sciences2020，32，1： | 2 |
| 3 | Phosphatidylinositol 3‐kinase is a central mediator of NMDA receptor signalling to MAP kinase (Erk1/2), Akt/PKB and CREB in striatal neurones显示文摘 | JamesIp Gemma L.Wood Andrew J.Crossthwaite Robert J.Williams | 2002 | Journal of Neurochemistry2002，，2： | 1 |
| 4 | High–Speed electron beam curing of thick electrode for high energy density Li-ion batteries显示文摘Electron beam curing is demonstrated as a promising method for high speed,low cost and environmentally friendly battery electrode manufacturing.This work reports transfer of this process to pilot scale equipment and evaluation of electrochemical performance in prototype 1.5 Ah pouch cells.Thick LiNi0.5Mn0.3Co0.2O2(NMC532)composite electrodes with an areal loading of 25 mg cm^-2(~4 mAh cm^-2)are successfully cured at a line speed of 500 feet per minute at 275 keV.Compared to the NMC532 cathode processed via a conventional coating method,the electron beam cured electrodes show higher capacity fade in the first 100 cycles,but similar fade rate afterwards.Further improvement strategies are proposed and discussed.This work demonstrates that electron beam curing is a promising method for manufacturing thick battery electrodes at high speeds and low capital/operation cost. | Zhijia Du Christopher J.Janke Jianlin Li David L.Wood III | 2019 | Green Energy & Environment2019，4，4： | 1 |
| 5 | Developmental D‐methamphetamine treatment selectively induces spatial navigation impairments in reference memory in the Morris water maze while sparing working memory显示文摘 | Michael T.Williams Laronda L.Morford Sandra L.Wood Tanya L.Wallace MasaoFukumura Harry W.Broening Charles V.Vorhees | 2003 | Synapse2003，，3： | 1 |
| 6 | 原子核转动谱的Harris公式与吴-曾公式的综合比较显示文摘本文对大变形原子核的能谱,转动惯量和γ跃迁能量的系统分析表明,吴-曾公式优于被广泛使用的Harris公式。J^((2))>J^((1))这一事实可以从吴-曾公式自然得出,而在吴-曾公式推导中,原子核的非轴对称性及振动效应已在一定程度上被考虑进去。 | 曾谨言 黄海新 John L.Wood | 1989 | 中国科学(A辑)1989，20，4： | 0 |
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