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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 高血压患者肾素血管紧张素系统阻断的血浆分子标志:肾损害与初发蛋白尿的新预测指标显示文摘蛋白尿是一个与心血管病密切相关的危险因素,也是一般人群的首位死亡原因。虽然已经明确肾素血管紧张素系统(renin-angiotensin system,RAS)阻断剂能延缓高血压患者初发蛋白尿进展、减少蛋白尿排出,但仍不能忽视高血压患者发生初发蛋白尿的比例。 | Baldan-Martin M Mourino-Alvarez L Gonzalez-Calero L Moreno-Luna R Sastre-Oliva T Ruiz-Hurtado G Segura J Lopez JA Vazquez J Vivanco F Alvarez-Llamas G Ruilope LM de la Cuesta F Barderas MG 赵狄 练桂丽 | 2016 | 中华高血压杂志2016，24，6： | 2 |
| 3 | 2013年美国心脏病学会/美国心脏协会胆固醇管理指南在美国心脏病学实践中的应用显示文摘2013年美国心脏病学会/美国心脏协会(American College of Cardiology/American Heart Association,ACC/AHA)胆固醇管理指南建议在符合治疗标准的患者中采用中等强度至高强度他汀类药物治疗。该研究的目的在于审查2013年ACC/AHA指南在美国心脏病学实践中的应用情况。 | 刘莉 叶鹏 Pokharel Y Tang F Jones PG Nambi V Bittner VA Hira RS Nasir K Chan PS Maddox TM Oetgen WJ Heidenreich PA Borden WB Spertus JA Petersen LA Ballantyne CM Virani SS | 2017 | 中华高血压杂志2017，25，6： | 2 |
| 4 | No-reflow during coronary intervention :observations and implications 显示文摘 | Leopold JA Berger C J Cupples LA | 2000 | Circulation2000，102，： | 2 |
| 5 | Coronary artery calcium areas by electron beam computed tomography and coronary atherosclerotic plaque area: A histopathologic corrlative study 显示文摘 | Simons DB Fitzpatrick LA Sheedy PF Schwartz RS | 1995 | Circulatiom1995，92，： | 1 |
| 6 | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects 显示文摘 | Conquer JA Cheryk LA Chan E | 1999 | ThrombRes1999，96，3： | 1 |
| 7 | Single cell electrophoresis in determining cell death:potential for use in organ transplant research显示文摘 | Johnson LA Ferris JA | 2005 | J Biochem Biophys Methods2005，63，1： | 1 |
| 8 | Loss of protein, immunoglobulins, and electrolytes in exudates from negative pressure wound therapy显示文摘 | Hourigan LA Linfoot JA Chung KK | 2010 | Nutr Clin Pratt2010，25，5： | 1 |
| 9 | Transanal endo - rectal pull - through for Hischpmng ~s disease 显示文摘 | DE LA TORRE - MONDRAGON L ORTEGA - SALGADO JA | 1998 | J Pediatr Surg1998，33，8： | 1 |
| 10 | Effect of supplementation with dietary seal oil on selected cardiovascular risk factors and hemostatic variables in healthy male subjects显示文摘 | Conquer JA Cheryk LA Chan E | 1999 | Thromb Res1999，96，3： | 1 |
| 11 | No-reflow during coronary intervetion: observations and implications 显示文摘 | Leopold JA Berger CJ Cupples LA | | Circulation0，102，： | 1 |
| 12 | Metabolic syndrome in childhood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later 显示文摘 | Morrison JA Friedman LA Wang P | 2008 | J Pediatr2008，152，2： | 1 |
| 13 | Metabolic syndrome in child- hood predicts adult metabolic syndrome and type 2 diabetes mellitus 25 to 30 years later显示文摘 | Morrison JA Friedman LA Wang P | 2008 | J Pediatr2008，152，2： | 1 |
| 14 | Comparison of intravitreal versus posterior sub - Tenon' s capsule injection of triameinolone aeetonide for diffuse diabetic macular edema显示文摘 | Cardillo JA Melo LA Jr Costa RA | 2005 | Ophthahnology2005，112，9： | 1 |
| 15 | The incidence of thrombotic thromlx~ytopenic purpura- hemolytic uremic syndrome: All patients, idiopathic patients, and patients with severe ADAMTS13 deficiency 显示文摘 | Terrell DR Williams LA Vesely SK Lammle B Hovinga JA George JN | 2005 | J Thromb Haem- ost2005，3，7： | 1 |
| 16 | A Wolbachia symbiont in Aedes aegypti limits infection with dengue,Chikungunya,and Plasmodium显示文摘 | Moreira LA Iturbe-Ormaetxe I Jeffery JA | | 0，，7： | 1 |
| 17 | Pharmacological treatment of generalized anxiety disorder显示文摘 | Reinhold JA Mandos LA Rickels K | | 0，，16： | 1 |
| 18 | An Apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing显示文摘 | Pennacchio LA Olivier M Hubacek JA | | 0，，： | 1 |
| 19 | CTLA4Ig: Bridging the basic immunology with clinical application 显示文摘 | Bluestone JA St Clair EW Turka LA | 2006 | Immunity2006，24，3： | 1 |
| 20 | Positive Affect and the experience of meaning in life显示文摘 | King LA Hicks JA Krull JL | 2006 | J Pers Soc Psychol2006，90，： | 1 |
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