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419篇 您的检索式:作者名="LAKE S"
    题名 作者 年代 出处 被引量
1Notch signaling: cell fate control and signal integration in development显示文摘Artavanis-Tsakonas S Rand MD Lake RJ 1999Science1999,284,:2
2Apolipoprotein B100 quality control and the regulation of hepatic very low density lipoprotein secretion显示文摘Apolipoprotein B (apoB ) 是很低的密度脂蛋白(VLDL ) 的主要蛋白质部件并且为这些 triglyceride (TG ) 的集会和分泌物是必要的富有的粒子。从肝的后面的版本, VLDL 在血浆被变换成低密度脂蛋白(LDL ) 并且增加了 VLDL 的生产能因此在心血管的疾病起一个有害作用。增加的证据帮助了为 dyslipidemias 的处理作为一个目标建立 VLDL 汇编。多重因素涉及合拢 apoB 蛋白质和一个分泌物能干的 VLDL 粒子的形成。没有通过的 VLDL 汇编能在 hepatocyte 开始质量控制机制为降级的那目标 apoB。ApoB 是底层因为 endoplasmic 蜂窝胃由 ubiquitin proteasome 系统并且为 autophagy 联系了降级(ERAD ) 。有效指向和 apoB 的处理是调制 VLDL 分泌物的一个调整过程并且 TG 划分。新兴的证据建议那重要重叠在这些 degradative 小径之间存在。例如,到 autophagy 和展开的蛋白质反应(UPR ) 的饭后的激活的 apoB 的调停胰岛素的指向可以采用一样的细胞的机械和规章的暗示。在为 apoB 的质量控制机制的变化影响肝的生理学和病理状态,包括胰岛素抵抗和脂肪肝。发信号的胰岛素,类脂化合物新陈代谢和肝的 UPR 可以影响 VLDL 生产,特别地在饭后的状态期间。在我们总结我们 VLDL 的当前的理解的这评论,汇编, apoB 降级,质量控制机制和这些的角色在肝生理学并且处于病理学的状态处理。Eric Fisher Elizabeth Lake Roger S McLeod 2014The Journal of Biomedical Research2014,28,3:2
3Notch signaling: cell fate control and signal integration in development 显示文摘Artavanis - Tsakonas S Rand MD Lake RJ 1999Science1999,284,5415:1
4Notch signa- ling: cell fate control and signal integration in develop- ment显示文摘Artavanis-Tsakonas S Rand MD Lake RJ 1999Science1999,284,5415:1
5Nitrogen isotope ratios in estuarine biota collected along a nutrient gradient in Narragansett Bay, Rhode Island, USA 显示文摘Pruell R J Taplin B K M Lake J L Jayaraman S 2006Marine Pollution Bulletin2006,52,6:1
6Habitat structure,resources and diversity:The separate effects of surface roughness and macroalgae on stream invertebrates显示文摘Downes B Lake P S Schreiber E S G 2000Oecologia2000,123,:1
7Journal of Materials Science显示文摘Chen C P Lakes R S 199126(2):53971991,26,2:1
8Notch signaling : cell fate control and signal integration in development 显示文摘Artavanis-Tsakonas S Rand MD Lake RJ 1999Science1999,284,5415:1
9Isolation and functional expression of human CoQ2, a gene encoding a polyprenyl transierase involved in the synthesis of CoQ 显示文摘Forsgren M Attersand A Lake S 2004Biochem J2004,382,:1
10Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous显示文摘Lake S L 2003Human Heredity2003,55,1:1
11Isotope fractionation and atmospheric oxygen: Implications for phan- erozoic 02 evolution显示文摘Berner R A Petsch S T Lake J A Beerling D J 2000Science2000,287,:1
12Foam structure with a negative Poisson's ratio显示文摘LAKES R S 1987Science1987,,235:1
13Notch signaling: Cellfate control and signal integration in development 显示文摘Artavanis-Tsakonas S Rand MD Lake RJ 1999Science1999,284,5415:1
14Notch signaling: cell fate control and signal integration in development 显示文摘Artavanis-Tsakonas S Rand MD Lake RJ 1999Science1999,284,:1
15Negative Poisson's ratio polymeric and metallic foams 显示文摘FRIIS E A LAKES R S PARK J B 1988Journal of Material Science1988,,23:1
16Australian futures:Aquatic ecosystems and human water usage显示文摘Lake P S Bond N R 0,,39:1
17Development of a passively deployed roll-out solar array显示文摘Barret R Campbell D Lake M S 2006AIAA Journal2006,4011,:1
18NOTCH signaling: cell fate control and signal integration in development显示文摘Artavanis Tsakonas S Rand M D Lake R J 1999Science1999,284,5415:1
19Flow microfluorometric analysis of sperm DNA content: effect of cell shape on the fluorescence distribution 显示文摘GLEDHtLL B L LAKE S STEINMETZ L L 1976J Cellular Physiot1976,87,:1
20Negative Poisson's ratio polyethylene foams 显示文摘BRANDEL B LAKES R S 2001Journal of Materials Science2001,,36:1
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