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	题名	作者	年代	出处	被引量
1	LMP2-DC Vaccine Elicits Specific EBV-LMP2 Response to Effectively Improve Immunotherapy in Patients with Nasopharyngeal Cancer显示文摘Objective To evaluate the safety and effectiveness of a vaccine based on latent membrane protein 2(LMP2)modified dendritic cells(DCs)that boosts specific responses of cytotoxic T lymphocytes(CTLs)to LMP2 before and after intradermal injection in patients with nasopharyngeal carcinoma(NPC).Methods DCs were derived from peripheral blood monocytes of patients with NPC.We prepared LMP2-DCs infected by recombinant adenovirus vector expressing LMP2(rAd-LMP2).NPC patients were immunized with 2×105 LMP2-DCs by intradermal injection at week 0 and after the second and fourth weeks.Specific responses to LMP2 were detected by enzyme-linked immunospot(ELISPOT)assay at week 0 and at the fifth and eighth weeks.Local clinicians performed the follow-up and tracking of patients.Results We demonstrated that DCs derived from monocytes displayed typical DC morphologies;the expression of LMP2 in the LMP2-DCs vaccine was confirmed by immunocytochemical assay.Twenty-nine patients with NPC were enrolled in this clinical trial.The LMP2-DCs vaccine was well tolerated in all of the patients.Boosted responses to LMP2 peptide sub-pools were observed in 18 of the 29 patients with NPC.The follow-up data of 29 immunized patients from April,2010 to April 2015 indicated a five-year survival rate of 94.4%in responders and 45.5%in non-responders.Conclusion In this pilot study,we demonstrated that the LMP2-DCs vaccine is safe and effective in patients with NPC.Specific CTLs responses to LMP2 play a certain role in controlling and preventing the recurrence and metastasis of NPC,which warrants further clinical testing.	ZENG Yi SI Yong Feng LAN Gui Ping WANG Zhan ZHOU Ling TANG Min Zhong SJ O`Brien LAN Jiao ZHOU Xiang Yang WANG Yong Li TANG Juan ZHOU Zhi Xiang DU Hai Jun LIN Hui	2020	Biomedical and Environmental Sciences2020，33，11：	2
2	A polymovphism in toll-interleukin 1 receptor domain containing adaptor protein is associated with susceptibility to meningeal tuberculosis 显示文摘	Hawn TR Dunstan SJ Thwaites GE Simmons CP Thuong NT Lan NT	2006	J Infect Dis2006，194，8：	1
3	Early diagnosis ofventriculoperitoneal shunt infections and malfunctions inchildren with hydrocephalus显示文摘	Lan CO Wong TT Chen SJ	2003	J Microbiol Immunol Infect2003，36，：	1
4	Sleep complaints and depression in an aging cohort:A p rospective perspective显示文摘	Roberts RE Shema SJ Kap lan GA	2000	Am J Psychiatry2000，157，：	1
5	A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis显示文摘	Thuong NT Hawn TR Thwaites GE Chau TT Lan NT Quy HT Hieu NT Aderem A Hien TT Farrar JJ Duns- tan SJ	2007	Genes Im- mun2007，8，5：	1
6	Relationship between remaining teeth and serf-rated chewing ability among population aged 45 years or older in Kaohsiung City,Taiwan显示文摘	Hsu KJ Yen YY Lan SJ	2011	Kaohsiung J Med Sci2011，27，10：	1
7	Tc-99m albumin scintigraphy to monitor the effect of treatment in protein-losing gastroenteropathy显示文摘	Wang SJ Tsai SC Lan JL	2000	Clan Nucl Med2000，25，：	1
8	Self - management education for adults with type 2 diabetes 显示文摘	Norris SL Lan J Smith SJ	2002	Diabetes Care2002，25，7：	1
9	A common human TLR1 pol- ymorphism regulates the innate immune response to lipopep- tides显示文摘	Hawn TR Misch EA Dunstan SJ Thwaites GE Lan NT Quy HT Chau TT Rodrigues S Naehman A Janer M Hien TT Farrar JJ Aderem A	2007	Eur J Immunol2007，37，8：	1
10	The effect of BMP-2 on micro- and macroscaleosteointegration of biphasic calcium phosphatescaffolds with multiscale porosity 显示文摘	Lan Levengood SK Polak SJ Poellmann MJ	2010	Acta Biomater2010，6，8：	1
11	Surgical treatment of pilon fracture based on ankle position at the time of injury/initial direction of frac- ture displacement: a prospective cohort study显示文摘	Wci SJ Han F Lan SH	2014	Int J Surg2014，12，5：	1
12	Self - management education for adults with type 2 diabetes 显示文摘	Norris SL Lan J Smith SJ	2002	Diabetes Care2002，25，11：	1
13	A novel missense mutation of the SMPD1 gene in a Taiwanese patient with type B Niemann - Pick disease 显示文摘	Lan MY Lin SJ Chen YF	2009	Ann Hematol2009，88，7：	1
14	Arylnaphthalene lignan glycosides and other constituents from Phyllanthus reticulatus 显示文摘	Ma JX Lan MS Qu SJ	2012	J Asian Nat Prod Res2012，14，11：	1
15	Early diagnosis of ventriculoperitoneal shunt infections and malfunctions in children with hydrocephalus 显示文摘	Lan CC Wong TF Chen SJ	2003	J Microbiol Immunol Infect2003，36，1：	1
16	Neuroglobin,a novel intracellular hexa-coordinated globin,functions as a tumor suppressor in hepatocellular carcinoma via Raf/MAPK/Erk显示文摘	Zhang J Lan SJ Liu QR	2013	Mol Pharmacol2013，83，5：	1
17	A cohort study on mortality and exposure to polychlorinated biphenyls 显示文摘	Hsieh SF Yen YY Lan SJ	1996	Archives of Environmental Health1996，51，：	1
18	Tea eonsumption: fluid intake and bladder cancer risk in southern Taiwan显示文摘	LU CM LAN SJ LEE YH	1999	Urology1999，54，5：	1
19	TGF-3 alters the healing of cutaneous fetal excisional wounds 显示文摘	Lanning DA Nwomeh BC Montante SJ	1999	J Pediatr Surg1999，34，：	1
20	Self-management education for adults with type 2 diabetes:a meta-analysis of the effect on glycemic control 显示文摘	Norris sl Lan J Smith SJ Schmid CH Engelgau MM	2002	Diabetes Care2002，25，：	1

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