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| 1 | A randomized controlled trial of imipramine in patients with irritable bowel syndrome显示文摘AIM: To study the efficacy of low-dose imipramine in relieving symptoms associated with the irritable bowel syndrome (IBS). METHODS: A randomized, double-blind trial of 25 mg imipramine vs matched placebo for 12 wk was performed. Doubling the dose was allowed once at week 2 in case of an unsatisfactory early response. Primary efficacy variables were subjective global symptom relief and quality of life (QoL) using SF-36 at week 12. RESULTS: One hundred and seven patients were enrolled by advertisement or referral by general practitioners and 56 (31 imipramine: 25 placebo) completed the 16-wk study. Baseline characteristics were comparable. A high overall dropout rate was noted in the imipramine and placebo arms (47.5% vs 47.9%, P > 0.05), a mean of 25.0 and 37.4 d from enrollment, respectively (P < 0.05). At the end of 12 wk, there was a significant difference in global symptom relief with imipramine over placebo (per-protocol: 80.6% vs48.0%, P = 0.01) and a trend on intent-to-treat (ITT) analysis (42.4% vs 25.0%, P = 0.06). This improvement was evident early and persisted to week 16 (P = 0.024 and 0.053 by per-protocol and ITT analyses, respectively). Mean cumulative and componentspecific SF-36 scores improved in the imipramine group only (per-protocol, P < 0.01). Drug-related adverse events leading to patient dropout were more common in the imipramine group (25.4% vs 12.5%, P > 0.05). CONCLUSION: Imipramine may be effective in the treatment of IBS patients and is associated with improved QoL. Careful patient selection, initiation of a low dose with gradual escalation and monitoring for side effects may result in an improved therapeutic response. | Heitham Abdul-Baki Ihab I El Hajj Lara ElZahabi Cecilio Azar Elie Aoun Assaad Skoury Hani Chaar Ala I Sharara | 2009 | World Journal of Gastroenterology2009，15，29： | 11 |
| 2 | Relationships between ethylene, abscisic acid and quality during postharvest storage of'Granny Smith' apples显示文摘 | LARA I VENDRELL M | 1998 | Postharvest Biology and Technology1998，13，1： | 1 |
| 3 | Effect of the cutting process on the fatigue behavior of press hardened and high strength dual phase steels 显示文摘 | Lara A Picas I Casellas D | 2013 | Journal of Materials Processing Technology2013，213，11： | 1 |
| 4 | Aroma volatile compounds of Fuji apples in relation to harvest date and cold storage technology: A comparison of two seasons显示文摘 | ECHEVERRIA G FUENTES T GRAELL J LARA I LOPEZ M L | 2004 | Postharvest Biology and Technology2004，32，： | 1 |
| 5 | Numerical analysis of wave overtopping of rubble mound breakwaters显示文摘 | Losada I J Lara J L Guanchea R Gonzalez-Ondina J M | 2008 | Coastal Engineering2008，55，1： | 1 |
| 6 | A comparison of pal iative stenting or emergent surgery for obstructing incurable colon cancer显示文摘 | Vemulapal i R Lara LF Sreenarasimhaiah J | | 0，，10： | 1 |
| 7 | ACC oxidase activation by cold storage on 'passe-crassane' pears: Effect of calcium treatment显示文摘 | Lara I Vendrall M | 1998 | J Sci Food Agric1998，26，： | 1 |
| 8 | Multivariate analysis of modifications in biosynthesis of volatile compounds after CA storage of 'Fuji' apples显示文摘 | Lara I Graell J Lopez M L | 2006 | Postharvest Biology and Technology2006，39，： | 1 |
| 9 | Tsunami wave interaction with mangrove forests: A 3-D numerical approach显示文摘 | MAZA M LARA J L LOSADA I J | 2015 | Coastal Engineering2015，98，： | 1 |
| 10 | ACC oxidase activation by cold storage on Passe-crassane pears:Effect of calcium treatment显示文摘 | LARA I VENDRAL M | 1998 | J Sci Food Agr1998，76，： | 1 |
| 11 | Reducing replacement donors in Sub-Saharan Africa: challenges and afford- ability显示文摘 | Bates I Manyasi G Lara A M | 2007 | Transfusion Medicine2007，17，6： | 1 |
| 12 | Postharvest heat treatments modify cell wall composition of strawberry显示文摘 | Lara I Garcia P Vendrell M | 2006 | Sci Hort2006，，109： | 1 |
| 13 | Diffuse alveolar hemorrhage显示文摘 | Lara R Schwarz I | | 0，，05： | 1 |
| 14 | Biosynthesis of volatile aroma compounds in pear fruit stored under long-term controlled-atmosphere conditions显示文摘 | LARA I MIRO R M FUENTES T | 2003 | Postharvest biology and technology2003，29，5： | 1 |
| 15 | SU5416 plus inter- feron alpha in advanced renal cell carcinoma a phase imaging cor- relates of angiogenesis inhibition 显示文摘 | LARA P N JR QUINN D I MARGOLIN K | 2006 | Clin Cancer Res2006，9，130： | 1 |
| 16 | ACC oxidase activiation by cold storage on ' Pass-Crassane' pears: effect of calcium treatment显示文摘 | Lara I Vendrell M | 1998 | Journal of the Science of Food and Agriculture1998，76，3： | 1 |
| 17 | Post-harvest heat treatments modify cell wall composition of stawberry fruit显示文摘 | LARA I GARCIA P VENDRELL M | 2006 | Sci Hort2006，109，： | 1 |
| 18 | Biosynthesis of volatile aroma compounds in pear fruit storedunder long-term controlled-atmosphere conditions显示文摘 | LARA I MIRO RM1 FUENTES T SAYEZ G GRAELL J LOPEZML | 2003 | PostharvestBiology and Technology2003，29，： | 1 |
| 19 | Diffuse alveolar hemorrhage 显示文摘 | Lara R Schwarz I | 2010 | Chest2010，137，5： | 1 |
| 20 | Accounting conservatism and corporate governance显示文摘 | Garc i a Lara J M Garcia Osma B Penalva F | 2011 | Review of Accounting Studies2011，14，1： | 1 |
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