|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Gray matter atrophy in Parkiuson's disease with dementia and dementia with Lewy bodies显示文摘 | Beyer MK Larsen JP Aarsland D | 2007 | Neurology2007，69，8： | 1 |
| 3 | A retrospective review of children hospita- lised with urinary tract calculi 显示文摘 | Simonsgaard M Larsen MK | 2008 | Ugeskr Laeger2008，170，23： | 1 |
| 4 | A magnetic resonance imaging study of patients with Parkinson 's disease with mild cognitive impairment and dementia using voxel-based morphometry显示文摘 | Beyer MK Janvin CC Larsen JP | | 0，，： | 1 |
| 5 | Chemical composition and sensory quality of bovine milk as affected by type of forage and proportion of concentrate in the feed ration显示文摘 | LARSEN MK KIDMOSE U KRISTENSEN T | 2013 | J Sci Food Agric2013，93，1： | 1 |
| 6 | Large mo- lecular size EDTA-resistant complexes containingS100A12,ERAC,in serum during inflammatory condi- tions显示文摘 | Fagerhol MK Larsen A Brun JG | 2012 | Scand J Clin Lab Invest2012，72，2： | 1 |
| 7 | Dynamics of human DNA topoisomerases Ⅱalpha and Ⅱbeta in living cells 显示文摘 | Christensen MO Larsen MK Barthelmes HU | 2002 | J Cell Biol2002，157，1： | 1 |
| 8 | A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel-based morphometry显示文摘 | Beyer MK Janvin CC Larsen JP | 2007 | J Neurol Neurosurg Psychiatry2007，78，： | 1 |
| 9 | A magnetic resonance imaging study of patients with Parkinson′s disease with mild cognitive impair-ment and dementia using voxel-based morphometry显示文摘 | Beyer MK Janvin CC Larsen JP | | 0，，： | 1 |
| 10 | A magnetic resonance imag-ing study of patients with Parkinson ’ s disease with mild cognitiveimpairment and dementia using voxel - based morphometry 显示文摘 | Beyer MK Janvin CC Larsen JP | 2007 | JNeurol Neurosurg Psychiatry2007，78，： | 1 |
| 11 | A magnetic resonance imaging study of patients with Parkinson's disease with mild cognitive impairment and dementia using voxel - based morphometry 显示文摘 | Beyer MK Janvin CC Larsen JP | 2007 | J Neurel Neurosurg Psy- chiatry2007，78，3： | 1 |
| 12 | Enterococcus in surface waters from the Des Moines River (Iowa) watershed: location, persistence and vancomycin resistance 显示文摘 | Larsen B Essmann MK Geletta S | 2011 | Int J Environ Health Res2011，22，4： | 1 |
| 13 | Cancer-associated cleavageof cytokeratin 8/18 heterotypic complexes exposes a neoepitope inhuman adenocarcinomas显示文摘 | Ditzel HJ Strik MC Larsen MK | 2002 | J Biol Chem2002，277，21： | 1 |
| 14 | Gray matter atrophy in Parkin- son disease with dementia and dementia with Lewy bodies显示文摘 | Beyer MK Larsen JP Aarsland D | 2007 | Neurology2007，69，8： | 1 |
| 15 | Sudden cardiac death in young adults:environmental risk factors and genetic aspects of premature atherosclerosis显示文摘 | Larsen MK Nissen PH Kristensen IB | | 0，，03： | 1 |
| 16 | Sudden car- diac death in young adults:Environmental risk factors and genetic aspects of permanture atherosclerosis显示文摘 | Larsen MK Nissen PH Kristensen IB | 2012 | J Forensic Sci2012，57，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员