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| 1 | Effect of hylan on cartilage and chondrocyte cultures显示文摘 | Larsen NE Lombard KM Parent EC | 1996 | J Orthoped Res1996，10，： | 1 |
| 2 | Contamination level of alginate impressions arriving at a dental laboratory 显示文摘 | Larsen T Fiehn NE Owall B | 2002 | Clin Oral Investig2002，6，3： | 1 |
| 3 | Effect of hylan on cartilage and chondrocyte cultures 显示文摘 | Larsen NE Lombard KM Parent EG | 1992 | J Orthoped Res1992，10，： | 1 |
| 4 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 5 | Contamination level of alginate impressions arriving at a dental laboratory显示文摘 | Sofou A Larsen T Fiehn NE | 2002 | Clin Oral Investig2002，6，3： | 1 |
| 6 | Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia 显示文摘 | Geisler CH Larsen JK Hansen NE | 1991 | Blood1991，78，7： | 1 |
| 7 | The effect of drying dental unit waterline bio-films on the bacterial load of dental unit water 显示文摘 | Fiehn NE Larsen T | 2002 | Int Dent J2002，52，4： | 1 |
| 8 | Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia 显示文摘 | Geisler CH Larsen JK Hansen NE | 1991 | Blood1991，78，7： | 1 |
| 9 | Effect of steam sterilization inside the turbine chambers of dental turbines显示文摘 | Andersen HK Fiehn NE Larsen T | 1999 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1999，87，2： | 1 |
| 10 | Intestinal first pass metabolism of midazolam in liver cirrhosis-effect of grapefruit juice 显示文摘 | ANDERSEN V PEDERSEN N LARSEN NE | 2002 | Br J Clin Pharmacol2002，54，2： | 1 |
| 11 | Identification of periodontal pathogens in atherosclerotic vessels显示文摘 | Fiehn NE Larsen T Christiansen N | | J Periodontol0，76，5： | 1 |
| 12 | Disinfection of dental impressions and occlusal records by ultraviolet radiation 显示文摘 | Larsen T Fiehn NE Peutzfeldt A | 2000 | Eur J Prosthodont Restor Dent2000，8，2： | 1 |
| 13 | Workshop on trichothecenes with a focus on DON:summary report显示文摘 | John Christian Larsen Josephine Hunt Irène Perrin | 2004 | Toxicology Letters2004，153，： | 1 |
| 14 | Intestinal first pass metabolism of midazolam in liver cirrhosis-effect of grapefruit juice 显示文摘 | Andersen V Pedersen N Larsen NE | 2002 | Br J Clin Phannacol2002，54，2： | 1 |
| 15 | Prognostic importance of flow cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia显示文摘 | Geisler CH Larsen JK Hansen NE | 1991 | Blood1991，78，7： | 1 |
| 16 | Disinfection of dental im-pressions and occlusal records by ultraviolet radiation显示文摘 | Larsen T Fiehn NE Peutzfeldt A | 2000 | Eur JProsthodont Restor Dent2000，8，2： | 1 |
| 17 | Prognostic importance of Flow Cytometric immunophenotyping of 540 consecutive patients with B-cell chronic lympholytic leukemia 显示文摘 | Geisler CH Larsen JK Hansen NE | 1991 | Blood1991，78，7： | 1 |
| 18 | Prognostic importance of flow cytomctric immunophenotyping of 540 consecutive patients with B-cell chronic lymphocytic leukemia 显示文摘 | Geisler CH Larsen JK Hansen NE | 1991 | Blood1991，78，7： | 1 |
| 19 | Evaluation of a new device for sterilizing dental high-speed handpieces显示文摘 | Larsen T Andersen HK Fiehn NE | 1997 | Oral surgery oral medicine oral pathology1997，84，： | 1 |
| 20 | Effect of steam sterilization inside the turbine chambers of dental turbines显示文摘 | Andersen HK Fiehn NE Larsen T | 1999 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod1999，87，2： | 1 |
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