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| 1 | Effect of Crataeva nurvala in experimental urolithiasis 显示文摘 | Varalakshmi P Shamila Y Latha E | 1990 | J Ethnopharmacol1990，28，3： | 1 |
| 2 | Clustering of cardio-vascular risk factors in urban Asian Indians显示文摘 | RAMACHANRAN A SHEHALATHA C LATHA E | 1998 | Diabetes Care1998，21，： | 1 |
| 3 | Studies on particulate matter (PMI0) and its precursors over urban environment of reading, UK显示文摘 | Latha K M Highwood E J | 2006 | Journal of Quantitative Spectroscopy and Radiative Transfer2006，101，2： | 1 |
| 4 | Crystallization and microhardess of calcium oxalate monohydrate显示文摘 | E K Girija S C Latha S N Kalkura | 1998 | Mater Chem Phys1998，52，3： | 1 |
| 5 | Studies on particulate matter (PM10) and its precursors over urban environment of Reading,UK显示文摘 | Latha Madhavi K Highwood E J | 2006 | Journal of Quantitative Spectroscopy and Radioactive Transfer2006，101，2： | 1 |
| 6 | Young breast cancer in a spe-cialised breast unit in Singapore : clinical, radiological and patholog-ical factors显示文摘 | Teo SY Chuwa E Latha S | 2014 | Ann Acad Med Singapore2014，43，2： | 1 |
| 7 | Studies on particulate matter (PM10) and its precursors over urban environment of Reading,UK显示文摘 | LATHA K M HIGHWOOD E J | 2006 | Journal of Quantitative Spectroscopy & Radiative Transfer2006，101，2： | 1 |
| 8 | Crystallization and microhardness of calcium oxalate monohydrate显示文摘 | GIRIJA E K CHRISTIC LATHA S SUBRAMANIAN C | 1998 | Materials Chemistry and Physics1998，52，： | 1 |
| 9 | Studiesonparticulate matter (PM10) andits precursors over urban environment of reading, UK 显示文摘 | Latha K M Highwood E J | 2006 | Journal of Quantitative Spectroscopy & Radiative rans- fer2006，101，2： | 1 |
| 10 | Anti-steatotic and anti-fibrotic effects of the KCa3.1 channel inhibitor, Senicapoc, in non-alcoholic liver disease显示文摘AIM To evaluate a calcium activated potassium channel(KCa3.1) inhibitor attenuates liver disease in models of non-alcoholic fatty liver disease(NAFLD).METHODS We have performed a series of in vitro and in vivo studies using the KCa3.1 channel inhibitor, Senicapoc. Efficacy studies of Senicapoc were conducted in toxin-, thioacetamide(TAA) and high fat diet(HFD)-induced models of liver fibrosis in rats. Efficacy and pharmacodynamic effects of Senicapoc was determined through biomarkers of apoptosis, inflammation, steatosis and fibrosis. RESULTS Upregulation of KCa3.1 expression was recorded in TAA-induced and high fat diet-induced liver disease. Treatment with Senicapoc decreased palmitic aciddriven Hep G2 cell death.(P < 0.05 vs control) supporting the finding that Senicapoc reduces lipiddriven apoptosis in Hep G2 cell cultures. In animals fed a HFD for 6 wk, co-treatment with Senicapoc,(1) reduced non-alcoholic fatty liver disease(NAFLD) activity score(NAS)(0-8 scale),(2) decreased steatosis and(3) decreased hepatic lipid content(Oil Red O, P < 0.05 vs vehicle). Randomization of TAA animals and HFD fed animals to Senicapoc was associated with a decrease in liver fibrosis as evidenced by hydroxyproline and Masson's trichrome staining(P < 0.05 vs vehicle). These results demonstrated that Senicapoc mitigates both steatosis and fibrosis in liver fibrosis models.CONCLUSION These data suggest that Senicapoc interrupts more than one node in progressive fatty liver disease by its anti-steatotic and anti-fibrotic activities, serving as a double-edged therapeutic sword. | latha paka david e smith dawoon jung siobhan mccormack ping zhou bin duan jing-song li jiaqi shi yong-jie hao kai jiang michael yamin itzhak d goldberg prakash narayan | 2017 | World Journal of Gastroenterology2017，23，23： | 1 |
| 11 | Multiplex PCR assay for the detection of aflatoxigenic and non-aflatoxigenic Aspergilli 显示文摘 | Latha R Manonmani H K Rati E R | 2008 | Researvh Journal of Microbiology2008，3，4： | 1 |
| 12 | 3D- QSAR and docking studies on the HEPT derivatives of HIV-1 reverse transcriptase显示文摘 | Latha R S Vijayaraj R Singam E R A | 2011 | Chemical Biology & Drug Design2011，78，3： | 1 |
| 13 | Dependence of single-molecule junction conductance on molecular conformarion显示文摘 | Latha Venkataraman Jennifer E Klare Colin NuckoUs | 2006 | Nature2006，442，： | 1 |
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