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| 1 | How location and cellular signaling combine to activate the NLRP3 inflammasome显示文摘NOD-,LRR-,and pyrin domain-containing 3(NLRP3)is a cytosolic innate immune sensor of cellular stress signals,triggered by infection and sterile inflammation.Upon detection of an activating stimulus,NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammasome,which promotes the helical oligomeric assembly of the adaptor molecule ASC.ASC oligomers provide a platform for caspase-1 activation,leading to the proteolytic cleavage and activation of proinflammatory cytokines in the IL-1 family and gasdermin D,which can induce a lytic form of cell death.Recent studies investigating both the cellular requirement for NLRP3 activation and the structure of NLRP3 have revealed the complex regulation of NLRP3 and the multiple steps involved in its activation.This review presents a perspective on the biochemical and cellular processes controlling the assembly of the NLRP3 inflammasome with particular emphasis on structural regulation and the role of organelles.We also highlight the latest research on metabolic control of this inflammatory pathway and discuss promising clinical targets for intervention. | Anil Akbal Alesja Dernst Marta Lovotti Matthew S.J.Mangan Róisín M.McManus Eicke Latz | 2022 | Cellular & Molecular Immunology2022，19，11： | 2 |
| 2 | Reactive alternating current magnetron sputtering of dielectric layers显示文摘 | Scherer M Schmitt J Latz R Schanz M | 1992 | J Vac Sci Technol1992，10，4： | 1 |
| 3 | Reactive alternating current magnetron sputtering of dielectric layers显示文摘 | Schmitt M J Latz R Schanz M | 1992 | J Vac Sci Technol A1992，10，4： | 1 |
| 4 | Propofol-katamine in ixture for anesthesia in pediatric patients undergoing cardiac catheterization显示文摘 | Kogan A Efrat R Latz J | 2003 | J Cardiothorac Vase Anesth2003，17，8： | 1 |
| 5 | Thickness dependence of In2O3:Sn film growth显示文摘 | QIAO Z LATZ R MERGEL D | 2004 | Thin Solid Films2004，466，： | 1 |
| 6 | Hydrodynamic stimulation of dinoflagellate bioluminescence:A computational and experimental study显示文摘 | Latz M I Juhl A R Ahmed A M | | 0，，11： | 1 |
| 7 | Excitation of bioluminescence by laminar fluid shear associated with simple couette flow显示文摘 | Latz M I Case J F Gran R L | | 0，，06： | 1 |
| 8 | 丹麦国家海事博物馆显示文摘丹麦海事博物馆位于独特的历史和空间环境中:在丹麦最重要和最著名的建筑之一克伦堡城堡和文化庭院——一个新的、雄心勃勃的文化中心之间。BIG建议将博物馆放在地下,就在船坞的墙壁外侧,以便将船坞保留为开放的户外展示空间,保存其强有力的结构作为海事博物馆中心。将博物馆这样设置,使它在成为与克伦堡城堡和邻近的文化庭院相联系的文化环境的一部分的同时,彰显自身. | John Pries Jensen Henrik Kania Ariel Joy Norback Wallner Rasmus Pedersen Annette Jensen Dennis Rasmussen Jan Magasanik Jeppe Ecklon Karsten Hammer Hansen Rasmus Rodam Rune Hansen Alina Tamosiunaite Alysen Hiller Ana Merino Armen Menendian Andy Yu Andreas Johansen Baptiste Blot Christian Alvarez Christin Svensson Claudia Hertrich Claudio Moretti Cory Mattheis Eskild Nordbud Felicia Guldberg Finn N■rkj■r Gül Ertekin Jan Borgstr■m James Schrader Johan Cool Jonas M■nster Kirstine Ragnhild Malte Kloe Michael Andersen Michal Kristof Marc Jay Maria Mavriku Masatoshi Oka Oana Simionescu Pablo Labra Peter Rieff Qianyi Lim Sara Sosio Sebastian Latz Tina Lund H■jgaard Tina Troster Todd Bennet Xi Chen Xing Xiong Xu Li Zoltan Kalaszi Iwan Baan Rasmus Hjortshoj Luca Santiago Mora Dragoer Luftfoto Jens Lindhe Lorenzon Boddi Thiks Wolzak 陈子钰(译) | 2019 | 城市环境设计2019，0，2： | 0 |
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