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| 1 | 世界胃肠病学组织全球指南——发展中国家幽门螺杆菌感染显示文摘世界上有一半人口感染幽门螺杆菌(H.pylori),其感染率因地理位置、种族、年龄和社会经济状况不同而存在很大差异.在发展中国家较高.发达国家较低。但总体而言,近年世界许多地区的H.pylori感染率均呈下降趋势。 | Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F van der Merwe S Vaz Coelho LG Fock M Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BCY Krabshuis J Le Mair A 杜颖 戴宁 | 2011 | 胃肠病学2011，16，7： | 27 |
| 2 | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis显示文摘AIM:To determine if subclinical abnormal glucose tolerance(SAGT)has influence on survival of non-diabetic patients with liver cirrhosis.METHODS:In total,100 patients with compensatedliver cirrhosis and normal fasting plasma glucose were included.Fasting plasma insulin(FPI)levels were measured,and oral glucose tolerance test(OGTT)was performed.According to OGTT results two groups of patients were formed:those with normal glucose tolerance(NGT)and those with SAGT.Patients were followed every three months.The mean follow-up was932 d(range of 180-1925).Survival was analyzed by the Kaplan-Meyer method,and predictive factors of death were analyzed using the Cox proportional hazard regression model.RESULTS:Of the included patients,30 showed NGT and70 SAGT.Groups were significantly different only in age,INR,FPI and HOMA2-IR.Patients with SAGT showed lower 5-year cumulated survival than NGT patients(31.7%vs 71.6%,P=0.02).Differences in survival were significant only after 3 years of follow-up.SAGT,Child-Pugh B,and high Child-Pugh and Model for EndStage Liver Disease(MELD)scores were independent predictors of death.The causes of death in 90.3%of cases were due to complications related to liver disease.CONCLUSION:SAGT was associated with lower survival.SAGT,Child-Pugh B,and high Child-Pugh and MELD scores were independent negative predictors of survival. | Diego García-Compeán Joel Omar Jáquez-Quintana Fernando Javier Lavalle-González José Alberto González-González Linda Elsa Mu?oz-Espinosa Jesús Zacarías Villarreal-PérezEndocrinology Service and Department of Internal Medicine University Hospital 'Dr. José E. González' and Medical School Universidad Autónoma de Nuevo León Monterrey 64320 México Héctor J Maldonado-Garza | 2014 | World Journal of Gastroenterology2014，20，22： | 12 |
| 3 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 4 | Analysis of translation elongation factors from wheat during development and following heat shock显示文摘 | Gallic D R Le H Caldwell C Browning K S | 1998 | Biochemical and Biophysical Research Communications1998，245，： | 1 |
| 5 | Generalization of the phase-screen approximation for the scattering of acoustic waves显示文摘 | DE HOOP M V LE ROUSSEAU J H WU R S | 2000 | Wave Motion2000，，31： | 1 |
| 6 | Shear wave elastography of tumour growth in a human breast Cancer model with pathologieal correlation显示文摘 | Chamming's F Latorre-Ossa H Le Fr~re-Belda MA | 2013 | Eur Radiol2013，23，8： | 1 |
| 7 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 8 | Comparison of re- spiratory surrogates for gated lung radiotherapy without in- ternal dueials 显示文摘 | Korreman S Mostafavi H Le QT | 2006 | Acta Onco12006，45，3： | 1 |
| 9 | 显示文摘 | YU H LE S L ZENG X H | 2014 | Inorg Chem Commun2014，39，： | 1 |
| 10 | Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression 显示文摘 | Jyonouchi H Sun S Le H | 2001 | Journal of Neuroimmunology2001，120，： | 1 |
| 11 | How to diagnose rheumatoid arthritis early:a prediction model for persistent erosive arthritis显示文摘 | Visser H le Cessie S Vos K | 2002 | Arthritis Rheum2002，46，2： | 1 |
| 12 | VEGF kinoid vaccine, a therapeutic approach against tumor angiogenesis and metastases 显示文摘 | Rad FH Le Buanec H Paturance S | 2007 | Proc Natl Acad Sci USA2007，104，8： | 1 |
| 13 | Comparison of respiratory surrogates for gated lung radiotherapy without internal fiducials 显示文摘 | Korreman S Mostafavi H Le QT | 2006 | Acta Oncol2006，45，7： | 1 |
| 14 | Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons 显示文摘 | Le H H Carlson E M Chua J P Belcher S M | 2008 | Toxicology Letters2008，176，2： | 1 |
| 15 | Surrogate markers of health after titanium dental implant placement显示文摘 | Young C W Lee J S Le H | 2004 | J Oral Maxillofac Surg2004，62，11： | 1 |
| 16 | Transpelvic anasto-motic stenting: a good option for diversion after pyelo-plasty in children显示文摘 | LE T S LE C T LE T H | 2011 | J Pediatr Urol2011，7，： | 1 |
| 17 | Staple versus fibrin glue fixation in laparoscopic total extraperitoneal repair of inguinal hernia:a systematic review and meta-analysis显示文摘 | Kaul A Hutfless S Le H | | 0，，05： | 1 |
| 18 | Lung macrophages and dendritic cells express HLA - G molecules in pulmonary diseases 显示文摘 | Pangault C Le Friec G Caulet - Maugendre S Lena H Amiot L Guilloux V Onno M Fauchet R | 2002 | Hum Immunol2002，63，2： | 1 |
| 19 | Automated Page Orientation and Skew Angle Detection for Binary Document Images显示文摘 | Le D S Thoma G R Wechsler H | 1997 | Pattern Recognition1997，27，10： | 1 |
| 20 | Design and synthesis of a novel pyrrolidinyl pyrido pyrimidinone derivative as a potent in- hibitor of PI3Kalpha and mTOR 显示文摘 | Le PT Cheng H Ninkovic S | 2012 | Bioorg Med Chem Lett2012，22，15： | 1 |
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