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| 1 | syndecan-1和-2表达形式的变化可以预测前列腺癌生化复发显示文摘前列腺癌的临床特点不能准确确定患者是否会发生生化复发,因而不适合作为预后和复发的指标。需要新的分子标记物对患者进行适当的术前风险分层。本研究旨在评估syndecan-1和-2的表达改变是否可以预测临床局限性前列腺癌患者行前列腺根治术后的生化复发。取60份局限性前列腺癌患者的石蜡包埋组织标本,采用免疫组化染色检测syndecan-1和-2的表达。取10份良性前列腺增生患者的样本作为非恶性对照。利用半定量分析,对其进行染色评估。为探讨预后效果,用Kaplan—Meier生存曲线进行分析,并进行log—rank检验。在良性前列腺样本中,syndecan-1在基底层上皮细胞中有表达,在上皮分泌细胞的基侧膜上也有表达;syndecan-2则主要但挞底层上皮细胞中表达。前列腺癌样本中,两种syndecan的表达模式都转变成定位在颗粒状细胞质上。生存分析显示,在游离前列腺特异性抗原(fPSA)复发存活曲线中,正常和改变的syndecan-1和-2的表达存在显著差异(P〈0.05)。这些数据表明,syndecan—1和-2可以作为临床局灶性前列腺癌患者预后的标记物,从而改进前列腺特异性抗原(PSA)评估复发风险,增加风险分层。 | Rodrigo Ledezma Federico Cifuentes Ivan Gallegos Juan Fulla Enrique Ossandon Enrique A Castellon Hector R Contreras | 2011 | Asian Journal of Andrology2011，13，3： | 2 |
| 2 | Novel antibacterial electrospun mats based on poly(d,l-lactide)nanofibers and zinc oxide nanoparticles显示文摘 | RODR GUEZ-TOB AS H MORALES G LEDEZMA A | 2014 | J Mater Sci2014，49，24： | 1 |
| 3 | Seismic behavior of squart reinforced concrete shear walls 显示文摘 | Hidalgo P A Ledezma C A Jordan R M | 2002 | Earthquake Spectra2002，18，2： | 1 |
| 4 | Optimal geometric arrangement of staggered vertical plates natural convection 显示文摘 | BEJAN A | 1997 | ASME J Heat Transfer1997，119，4： | 1 |
| 5 | Experimental measurements and computational predic- tions for an internally cooled simulated turbine vane 显示文摘 | DEES J E BOGARD D G LEDEZMA G A | 2012 | ASME Journal of Turbomachinery2012，134，06： | 1 |
| 6 | Benchmark problems for incompressible fluid flows with structural interactions显示文摘 | BATHE K J LEDEZMA G A | 2007 | Computers and Structures2007，85，： | 1 |
| 7 | GA-stacking: evolutionary stacked generalization 显示文摘 | LEDEZMA A ALER A SANCHIS A | 2010 | Intelligent Data Analysis2010，14，1： | 1 |
| 8 | Seismic behavior of squat reinforced concrete shear walls 显示文摘 | Hidalgo P A Ledezma C A Jordan R M | 2002 | Earthquake Spectra2002，18，2： | 1 |
| 9 | Seismic behavior of squat reinforced concrete shear walls 显示文摘 | Hidalgo P A Ledezma C A Jordan R M | 2002 | Earthquake Spectra2002，18，2： | 1 |
| 10 | Seismic behavior of squart reinforced concrete shear walls 显示文摘 | HIDALGO P A LEDEZMA C A JORDAN R M | 2002 | Earthquake Spectra2002，18，2： | 1 |
| 11 | Optimal spacing between pin fins with impinging flow显示文摘 | Ledezma G Morega A M Bejan A | 1996 | Journal of Heat Transfer1996，118，3： | 1 |
| 12 | Efficacy of ajoene,an organosulphur derived from garlic,in the short-term therapy of tinea pedis显示文摘 | Ledezma E DeSousa L Jorquera A Sanchez J Lander A Rodriguez E | 1996 | Mycoses1996，39，910： | 1 |
| 13 | Cement formation by microbial poly (g glutamie acid) and fluoro-alumino silicate glass 显示文摘 | Ledezma Perez A S Romero Garcia J Vargas Gutierrez G | 2005 | Materials Letters2005，59，2425： | 1 |
| 14 | Streets tree networks and urban growth: Optimal geometry for quickest access between a finite-size volume and one point显示文摘 | LEDEZMA G A | 1998 | Physica: A1998，255，1： | 1 |
| 15 | Genetic di-versity of Bactrocera dorsalis (Diptera: Tephritidae) on the Hawaiian islands: implications for an introduction pathway into California 显示文摘 | Barr N B Ledezma L A Leblanc L | 2014 | Journal of Economic Ento- mology2014，107，5： | 1 |
| 16 | Dual AC-drive system with a reduced switch count显示文摘 | Ledezma E McGrath B Munoz A | 2001 | IEEE Transactions on Industry Appllications2001，37，5： | 1 |
| 17 | Seismic behavior of squat reinforced concrete shear walls 显示文摘 | HIDALGO P A LEDEZMA C A JORDAN R M | 2002 | Earthquake Spectra2002，18，2： | 1 |
| 18 | Experimen ta measurements and computational predictions for an in tegrally cooled simulated turbine vane显示文摘 | Dees J E Bogard D G Ledezma G A | 2012 | Journal of Tur bomachinery2012，134，06： | 1 |
| 19 | Waste to real energy:The first MFC powered mobile phone显示文摘 | Ieropoulos I A Ledezma P Stinchcombe A | 2013 | Physical Chemistry Chemical Physics2013，15，15： | 1 |
| 20 | Efficacy of ajoene in short-term therapy of tinea pedis显示文摘 | Ledezma E DeSousa L Jorquera A | 1996 | Mycoses1996，39，910： | 1 |
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