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| 1 | Dynamic modelling of real estate investment trusts and stock markets显示文摘 | Chien-Chiang Lee Mei-Se Chien Tsoyu Calvin Lin | 2011 | Economic Modelling2011，，2： | 1 |
| 2 | Convergence of normal stem cell and cancer stem cell developmental stage:Implication for differential therapies显示文摘Increased evidence shows that normal stem cells may contribute to cancer development and progression by acting as cancer-initiating cells through their interactions with abnormal environmental elements.We postulate that normal stem cells and cancer stem cells (CSC) possess similar mechanisms of self-renewal and differentiation.CSC can be the key to the elaboration of anti-cancer-based therapy.In this article,we focus on a controversial new theme relating to CSC.Tumorigenesis may have a critical stage characterized as a 'therapeutic window',which can be identified by asso-ciation of molecular,biochemical and biological events.Identifying such a stage can allow the production of more effective therapies (e.g.manipulated stem cells) to treat several cancers.More importantly,confirming the existence of a similar therapeutic window during the conversion of normal stem cells to malignant CSC may lead to targeted therapy specifically against CSC.This conversion information may be derived from investigating the biological behaviour of both normal stem cells and cancerous stem cells.Currently,there is little knowledge about the cellular and molecular mechanisms that govern the initiation and maintenance of CSC.Studies on co-evolution and interdependence of cancer with normal tissues may lead to a useful treatment paradigm of cancer.The crosstalk between normal stem cells and cancer formation may converge developmental stages of different types of stem cells (e.g.normal stem cells,CSC and embryonic stem cells).The differential studies of the convergence may result in novel therapies for treating cancers. | Shengwen Calvin Li Katherine L Lee Jane Luo Jiang F Zhong William G Loudon | 2011 | World Journal of Stem Cells2011，3，9： | 1 |
| 3 | Antiviral Therapy for Chronic Hepatitis B in Pregnancy显示文摘 | Calvin Pan Hannah Lee | 2013 | Semin Liver Dis2013，，02： | 1 |
| 4 | Application of nanofiber technology to nonwoven thermal insulation显示文摘 | GIBSON Phillip W LEE Calvin KO Frank | 2007 | Journal of Engineered Fabrics & Fibers (JEFF)2007，2，2： | 1 |
| 5 | Interaction Between Duct Fires and Ventilation Flow: An Experimental Study 显示文摘 | CALVIN K LEE ROBERT F CHAIKEN JOSEPH M SINGER | 2007 | Combustion Science and Technology2007，20，1： | 1 |
| 6 | Antiviral Therapy for Chronic Hepatitis B in Pregnancy显示文摘 | Calvin Pan Hannah Lee | 2013 | Semin Liver Dis2013，，02： | 1 |
| 7 | Validation of genetic variants associated with metabolic dysfunctionassociated fatty liver disease in an ethnic Chinese population显示文摘BACKGROUND Genetic factors play an important role in the pathogenesis and development of metabolic dysfunction-associated fatty liver disease(MAFLD).AIM To study the association of single nucleotide polymorphisms(SNPs),previously identified in Western populations,with the risk of MAFLD in a Singapore Chinese population and their interactions with environmental and medical risk factors.METHODS A retrospective case-control study was conducted with 72 MAFLD cases and 72 controls with no hepatic steatosis on computed tomography,magnetic resonance imaging,or controlled attenuation parameter score.Subjects were recruited from two tertiary hospitals.Genetic alleles such as NCAN,GCKR,LYPLAL1,PNPLA3,PPP1R3B,FDFT1,COL13A1,EFCAB4B,PZP,and TM6SF2 were genotyped using the TaqMan®Predesigned SNP Genotyping Assay.RESULTS Weight and body mass index(BMI)were 1.2-times higher in patients(70.6 kg,95%confidence interval[CI]:57.1-84.1 vs 60.8 kg,95%CI:48.5-73.1,P<0.001 and 26.9 kg,95%CI:23-40.8 vs 23.3 kg 95%CI:19-27.6,P<0.001 respectively).The prevalence of diabetes mellitus in patients was 40.3%and 20.8%in controls(P=0.011).Patients had higher mean triglycerides than controls(P<0.001).PNPLA3 GG was more likely to be associated with MAFLD(43.4%CC vs 69.7%GG,P=0.017,and 44.8%CG vs 69.7%GG,P=0.022).In multivariable analysis,hypertriglyceridemia(odds ratio[OR]:2.0495%CI:1.3-3.1,P=0.001),BMI(OR:1.295%CI:1.1-1.4,P<0.001)and PNPLA3 GG(OR:3.495%CI:1.3-9.2,P=0.014)were associated with MAFLD(area under the receiver operating characteristic curve of 0.823).CONCLUSION Among the Chinese population of Singapore,PNPLA3 homozygous GG allele is a strong predictor of MAFLD,whereas LYPLAL1,GCKR,FDFT1,COL13A1,PZP,and TM6SF2 are not significantly associated.Hypertriglyceridemia,high BMI,and PNPLA3 GG are independent predictors of MAFLD. | Guan Huei Lee Wah Wah Phyo Wai Mun Loo Raymond Kwok Taufique Ahmed Asim Shabbir Jimmy So Calvin Jianyi Koh Juanda Leo Hartono Mark Muthiah Kieron Lim Poh Seng Tan Yin Mei Lee Seng GeeLim Yock Young Dan | 2020 | World Journal of Hepatology2020，12，12： | 1 |
| 8 | Increasing Hospital Admission Rates for Urological Complications After Transrectal Ultrasound Guided Prostate Biopsy显示文摘 | Robert K. Nam Refik Saskin Yuna Lee Ying Liu Calvin Law Laurence H. Klotz D. Andrew Loblaw John Trachtenberg Aleksandra Stanimirovic Andrew E. Simor Arun Seth David R. Urbach Steven A. Narod | 2010 | The Journal of Urology2010，，3： | 1 |
| 9 | Investigation of air gaps entrapped in protective clothing systems 显示文摘 | KIM II Young LEE Calvin LI Peng | 2002 | Fire and Materials2002，26，3： | 1 |
| 10 | Low temperature iron- and nickel-catalyzed reactions leading to coalbed gas formation显示文摘 | Juan Carlos Medina Steven J Butala Calvin H Bartholomew Milton L Lee | 2000 | Geochimica et Cosmochimica Acta2000，，4： | 1 |
| 11 | Three-wavelength light transmission technique to measure smoke particle size and concentration显示文摘 | Kenneth L Cashdollar Calvin K Lee Joseph M Singer | 1979 | Applied Optics1979，18，： | 1 |
| 12 | Video-Assisted Thoracic Surgery Pulmonary Resection for Lung Cancer in Patients with Poor Lung Function显示文摘 | Juan C. Garzon Calvin S.H. Ng Alan D.L. Sihoe Anthony V. Manlulu Randolph H.L. Wong Tak Wai Lee Anthony P.C. Yim | 2006 | The Annals of Thoracic Surgery2006，，： | 1 |
| 13 | Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective显示文摘The development of single-cell subclones,which can rapidly switch from dormant to dominant subclones,occur in the natural pathophysiology of multiple myeloma(MM)but is often'pressed'by the standard treatment of MM.These emerging subclones present a challenge,providing reservoirs for chemoresistant mutations.Technological advancement is required to track MM subclonal changes,as understanding MM's mechanism of evolution at the cellular level can prompt the development of new targeted ways of treating this disease.Current methods to study the evolution of subclones in MM rely on technologies capable of phenotypically and genotypically characterizing plasma cells,which include immunohistochemistry,flow cytometry,or cytogenetics.Still,all of these technologies may be limited by the sensitivity for picking up rare events.In contrast,more incisive methods such as RNA sequencing,comparative genomic hybridization,or whole-genome sequencing are not yet commonly used in clinical practice.Here we introduce the epidemiological diagnosis and prognosis of MM and review current methods for evaluating MM subclone evolution,such as minimal residual disease/multiparametric flow cytometry/next-generation sequencing,and their respective advantages and disadvantages.In addition,we propose our new single-cell method of evaluation to understand MM's mechanism of evolution at the molecular and cellular level and to prompt the development of new targeted ways of treating this disease,which has a broad prospect. | Lisa X Lee Shengwen Calvin Li | 2020 | World Journal of Stem Cells2020，12，8： | 1 |
| 14 | 非接触安全控制器用于电子护照增强安全性显示文摘目前,全球许多国家均基于安全考虑而采用了电子护照,美国已在2006年起实施此规范。与传统护照相比,电子护照的最大特点在于它能够在芯片中储存拥有者的所有相关数据,透过非接触式芯片,以短距无线技术来存取并读取这些信息,海关能快速读取并掌握护照持有者的身份。随着电子护照逐渐为多个国家采用,也为各式各样的非接触式控制器开启了更大的市场。 | Calvin Lee | 2008 | 中国防伪报道2008，，6： | 0 |
| 15 | Pharmacological efficacy of the traditional Chinese medicinal formula Kun-Tai-1A in the treatment of letrozole-induced polycystic ovary syndrome显示文摘Background:Polycystic ovary syndrome(PCOS)is an endocrine disorder that occurs in women of child-bearing age.Moreover,PCOS patients have decreased pregnancy rates and clomiphene citrate resistance.The traditional Chinese medicine formula Kun-Tai-1S(KT1S),consisting of the seahorse species hippocampus,has been reported to elicit therapeutic effects in patients with PCOS.However,given the limited resources and global demand for wild hippocampus,whether KT1S with or without hippocampus can elicit similar therapeutic effects has not been confirmed.Methods:KT1S and Kun-Tai-1A(KT1A,KT1S without dry hippocampus)were used to treat a letrozole-induced rat model of PCOS with an established disease.The serum levels of testosterone,luteinizing hormone,anti-Müllerian hormone,and estradiol were determined,the luteinizing hormone/follicle-stimulating hormone ratio was determined,and the ovarian pathology was evaluated.Results:Similar to the therapeutic effects of cyproterone acetate,both the KT1S and KT1A treatments reduced the body weight and ovarian and uterine indices in the rats with PCOS.The serum levels of testosterone,anti-Müllerian hormone,and luteinizing hormone and the luteinizing hormone/follicle-stimulating hormone ratio were significantly lower in the KT1S and KT1A treatment groups compared to the model group(P<0.01 and P<0.05,respectively).Moreover,the histopathological assessment results suggested that both the KT1S and KT1A treatments significantly ameliorated the PCOS pathology in the rats with an established disease,with a reduced number of cystic and atretic follicles and an increased number of corpora lutea being observed in the ovaries.Notably,there was no obvious difference in the disease outcomes between the KT1S and KT1A-treated groups.Network pharmacology analysis revealed that 4’,7-dihydroxyflavanone,sinpemine A,quercetin,8-isopentenyl-kaempferol,and luteolin in KT1A may promote estrogen signaling;furthermore,the nitric oxide regulation pathway is also closely involved.Conclusion:KT1A and KT1S treatments both significantly ameliorated the PCOS-related pathology in rats,suggesting that the hippocampus component is dispensable for KT1S-mediated amelioration.Given the limited resources and global demand for wild hippocampus for use in complementary medicines,our findings may help conserve this species.Together,our results suggest that KT1A is a promising approach for treating PCOS. | Leanne Lee Leung Jing Xie Ya-Cun Chen Kar-Ho Lam Hei Wan Su-Lan Yu Tzi-Bun Ng George Pak-Heng Leung Jin Yu Ren-Min Yao Shu-Jia Sun Sydney Chi-Wai Tang Hai-Yong Chen Jia Zhao Zhang-Jin Zhang Calvin Kai-Fai Lee Kalin Yan-Bo Zhang Li-Xing Lao Yun Feng Xiang Lin Wei Meng | 2022 | Traditional Medicine Research2022，7，3： | 0 |
| 16 | 非接触安全控制器在电子护照上的应用显示文摘电子护照进入了一个集成非接触安全控制器的新技术时代,随着大规模的应用,这类文件的处理已经变得更安全和更方便。 | Calvin Lee Peter Laackmann Marcus Janke | 2007 | 中国防伪报道2007，，8： | 0 |
| 17 | Risk factors for ribavirin treatment failure in Asian organ transplant recipients with chronic hepatitis E infection显示文摘BACKGROUND Hepatitis E virus(HEV)infection is a cause of chronic hepatitis in immunosuppressed patients.Sustained virologic response rates to a 12-wk course of ribavirin therapy were reported to be>70%in the West.This study describes the outcome of HEV treatment in a transplant center in Singapore.AIM To study the outcome of ribavirin treatment in a series of chronic HEV patients,and the cause of treatment failure.METHODS We studied all of the transplant recipients who were diagnosed with HEV infection between 2012 to 2015.The outcome of therapy and virologic relapse are monitored for three years after the end of therapy.RESULTS Ten transplant recipients(4 liver,5 kidney,and 1 bone marrow transplantation)with positive HEV RNA were studied.Nine patients received at least 12 wk of ribavirin therapy,and the remaining patient resolved after reducing immunosuppression therapy.Two subjects had prolonged viremia that lasted more than one year,despite continuous ribavirin therapy.Four ribavirin-treated patients(44.4%)had HEV RNA relapse after achieving a virologic response by the end of treatment.The overall failure rate is 66.7%.Being a kidney transplant recipient is the strongest risk factor for not achieving an initial sustained virologic response(0/5 treated,Chi-Square test,P<0.05).The most common side effect of ribavirin is anemia(100%)(haemoglobin reduction of 3-6.2 g/dL).Seven patients required either a blood transfusion or erythropoietin therapy.CONCLUSION The sustained virologic response rate of 12-wk ribavirin therapy for HEV infection in this Asian series was lower than expected.Kidney transplant recipients had a higher rate of treatment failure due to higher immunosuppression requirements and adverse effects. | En Xian Sarah Low Edhel Tripon Kieron Lim Poh Seng Tan How Cheng Low Yock Young Dan Yin Mei Lee Mark Muthiah Wai Mun Loo Calvin Jianyi Koh Wah Wah Phyo JunXiong Pang Seng Gee Lim Guan-Huei Lee | 2019 | World Journal of Hepatology2019，11，6： | 0 |
| 18 | 为地球延续植物的未来显示文摘全世界有超过25万种的开花植物妆点着地球,其中六成以上集中在热带雨林。可是,热带雨林却遭受到前所未有的摧残,我们很难遏阻这个趋势。有一批学者专家正在努力收藏各种植物和种子,目的是保存地球上濒临灭绝的植物。 | Calvin Lee 哲伦 | 2009 | 资源与人居环境2009，，21： | 0 |
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