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| 1 | Butein effects in colitis and interleukin-6/signal transducer and activator of transcription 3 expression显示文摘AIM: To evaluate the effects of butein on inflammatory cytokines, matrix metalloproteinase-9(MMP-9), andcolitis in interleukin(IL)-10-/- mice.METHODS: To synchronize colitis, 8- to 10-wk-old IL-10-/- mice were fed pellet-chow containing piroxicam for 2 wk. Subsequently, phosphate-buffered saline or butein(1 mg/kg per day, ip) was injected for 4 wk. Histologic scores, inflammatory cytokines, MMP-9 and phosphorylated signal transducer and activator of transcription 3(p STAT3) expressions were analyzed in IL-10-/- mice and in Colo 205 cells.RESULTS: Butein reduced the colonic inflammatory score by > 50%. Expression levels of IL-6, IL-1β, interferon(IFN)-γ and MMP-9 were decreased in the colons of mice exposed to butein, whereas other inflammatory cytokines(IL-17 A, IL-21 and IL-22) were unchanged. Immunohistochemical staining for p STAT3 and MMP-9 was significantly decreased in the buteintreated groups compared with the controls. Butein inhibited IL-6-induced activation of STAT3 in Colo 205 cells.CONCLUSION: Butein ameliorated colitis in IL-10-/-mice by regulating IL-6/STAT3 and MMP-9 activation. | Sehe Dong Lee Jung Wan Choe Beom Jae Lee Myoung Hee Kang Moon Kyung Joo Ji Hoon Kim Jong Eun Yeon Jong-Jae Park Jae Seon Kim Young-Tae Bak | 2015 | World Journal of Gastroenterology2015，21，2： | 3 |
| 2 | Effect of γ-irradiation on the physicochemical properties of soy protein isolate films显示文摘 | Myoungsuk Lee Sehee Lee Kyung Bin Song | 2005 | Radiation Physics and Chemistry2005，72，： | 1 |
| 3 | Effect of plasticizer and cross-linking agent on the physical properties of protein films显示文摘 | Lee Myoungsuk Lee Sehee Ma Yuhyun | 2005 | Journal of Food Science and Nutrition2005，，： | 1 |
| 4 | Effect of T-irradiation on the physicochemical properties of zein films显示文摘 | Lee Sehee Lee Myoungsuk Song Kyung Bin | 2003 | Journal of Food Science and Nutrition2003，8，4： | 1 |
| 5 | A New Duplex Reverse Transcription PCR for Simultaneous Detection of Viable Cryptosporidium parvum Oocysts and Giardia duodenalis Cysts显示文摘Objective To simultaneously detect viable Cryptosporidium parvum oocysts and Giardia duodenalis cysts for the purpose of reducing time and cost spent. Methods A duplex reverse transcription polymerase chain reaction (RT-PCR) method was newly developed. Results Using duplex RT-PCR method for the hsp70 gene, viable (oo)cyst concentrations of 101 and 103 (oo)cysts/100 μL could be detected for C. parvum and G. duodenalis, respectively. However, after heat-shock stimulation the expression of hsp70 mRNAs was detectable at 100 and 101 (oo)cysts/100 μL concentrations of C. parvum and G. duodenalis, respectively. Thus, the detection sensitivity was significantly increased when the viable (oo)cysts were exposed to heat shock. Conclusion This study describes a new duplex RT-PCR method for hsp70 gene to detect the viable (oo)cysts of the C. parvum and G. duodenalis with less time consumed and at a lower cost. This newly developed duplex RT-PCR method may be used to detect these parasites not only in aquatic environments but also in clinical samples. | SEHEE NAM GYUCHEOL LEE | 2010 | Biomedical and Environmental Sciences2010，23，2： | 1 |
| 6 | Effect ofirradiation on the physicochemical properties of soy protein isolate films 显示文摘 | Myoungsuk Lee Sehee Lee Kyung Bin Soung | 2005 | Radaiation Physics and Chemistry2005，72，： | 1 |
| 7 | Comparison of electrochromic amorphous and crystalline tungsten oxide films显示文摘 | OZKAN ESRA LEE SEHEE TRACY C | 2003 | Solar Energy Material & Solar Cells2003，79，4： | 1 |
| 8 | Effect of - irradiation on the physieochemieal properties of soy protein isolate films显示文摘 | Myoungsuk Lee Sehee Lee Kyung Bin Song | 2005 | Radiation Physics and Chemistry2005，72，1： | 1 |
| 9 | Effect of plasticizer and cross-linking agent on the physical proper ties of protein films显示文摘 | Lee Myoungsuk Lee Sehee Ma Yuhyun | 2005 | Journal of Food Science and Nutrition2005，10，1： | 1 |
| 10 | Effect of plasticizer and cross-linking agent on the physical properties of protein films显示文摘 | Lee Myoungsuk Lee Sehee Ma Yuhyun | 2005 | Journal of Food Science and Nutrition2005，10，1： | 1 |
| 11 | Effect of γ- irradiation on the physicochemical properties of zein films 显示文摘 | Lee Sehee Lee Myoungsuk Song Kyung Bin | 2003 | Journal of Food Science and Nutrition2003，8，4： | 1 |
| 12 | Effect of γ-irradiation on the physicochemical properties of soy protein isolate films显示文摘 | Sehee Lee Kyung Bin Song | 2005 | Radiation Physics and Chemist ry2005，72，： | 1 |
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