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| 1 | Configurable Floating-Point FFT Accelerator on FPGA Based Multiple-Rotation CORDIC显示文摘Fast Fourier transform(FFT) accelerator and Coordinate rotation digital computer(CORDIC) algorithm play important roles in signal processing. We propose a configurable floating-point FFT accelerator based on CORDIC rotation, in which twiddle direction prediction is presented to reduce hardware cost and twiddle angles are generated in real time to save memory. To finish CORDIC rotation efficiently, a novel approach in which segmentedparallel iteration and compress iteration based on CSA are presented and redundant CORDIC is used to reduce the latency of each iteration. To prove the efficiency of our FFT accelerator, four FFT accelerators are prototyped into a FPGA chip to perform a batch-FFT. Experimental results show that our structure, which is composed of four butterfly units and finishes FFT with the size ranging from 64 to8192 points, occupies 33230(3%) REGs and 143006(30%)LUTs. The clock frequency can reach 122 MHz. The resources of double-precision FFT is only about 2.5 times of single-precision while the theoretical value is 4. What's more, only 13331 cycles are required to implement 8192-points double-precision FFT with four butterfly units in parallel. | CHEN Jiyang LEI Yuanwu PENG Yuanxi HE Tingting DENG Ziye | 2016 | Chinese Journal of Electronics2016，25，6： | 10 |
| 2 | TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-αpathway显示文摘Background:Inflammation is a complex physiological and pathological process.Although many types of inflammation are well characterized,their physiological func-tions are largely unknown.tRNA aspartic acid methyltransferase 1(TRDMT1)has been implicated as a stress-related protein,but its intrinsic biological role is unclear.Methods:We constructed a Trdmt1 knockout rat and adopted the LPS-induced sepsis model.Survival curve,histopathological examination,expression of inflammatory fac-tors,and protein level of TLR4 pathway were analyzed.Results:Trdmt1 deletion had no obvious impact on development and growth.Trdmt1 de-letion slightly increased the mortality during aging.Our data showed that Trdmt1 strongly responded in LPS-treated rats,and Trdmt1 knockout rats were vulnerable to LPS treat-ment with declined survival rate.We also observed more aggravated tissue damage and more cumulative functional cell degeneration in LPS-treated knockout rats compared with control rats.Further studies showed upregulated TNF-αlevel in liver,spleen,lung,and serum tissues,which may be explained by enhanced p65 and p38 phosphorylation.Conclusions:Our data demonstrated that Trdmt1 plays a protective role in inflamma-tion by regulating the TLR4-NF-κB/MAPK-TNF-αpathway.This work provides useful information to understand the TRDMT1 function in inflammation. | Zhengguang Li Xiaolong Qi Xu Zhang Lei Yu Lijuan Gao Weining Kong Wei Chen Wei Dong Lijun Luo Dan Lu Lianfeng Zhang Yuanwu Ma | 2022 | Animal Models and Experimental Medicine2022，5，2： | 5 |
| 3 | SARS-CoV-2 infection aggravates chronic comorbidities of cardiovascular diseases and diabetes in mice显示文摘Background:Cardiovascular diseases(CVDs)and diabetes mellitus(DM)are top two chronic comorbidities that increase the severity and mortality of COVID-19.However,how SARS-CoV-2 alters the progression of chronic diseases remain unclear.Methods:We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice.SARS-CoV-2’s impacts on pathogenesis of chronic diseases were studied through histopathological,virologic and molecular biology analysis.Results:Pre-existing CVDs resulted in viral invasion,ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection.Viral infection increased fasting blood glucose and reduced insulin response in DM model.Bone mineral density decreased shortly after infection,which associated with impaired PI3K/AKT/mTOR signaling.Conclusion:We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases.Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection,which further aggravated the pre-existing diseases.This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection. | Yuanwu Ma Dan Lu Linlin Bao Yajin Qu Jiangning Liu Xiaolong Qi Lei Yu Xu Zhang Feifei Qi Qi Lv Yunpeng Liu Xudong Shi Caixian Sun Jing Li Jie Wang Yunlin Han Kai Gao Wei Dong Ning Liu Shan Gao Jing Xue Qiang Wei Sidan Pan Hong Gao Lianfeng Zhang Chuan Qin | 2021 | Animal Models and Experimental Medicine2021，4，1： | 3 |
| 4 | Low-Latency SRT Division and Square Root Based on Remainder and Quotient Prediction显示文摘Sweeney, Robertson and Tocher(SRT) algorithm is a common and efficient way for division and square root(div/sqrt). We present to overlap two iterations into one cycle by predicting remainder and quotient.To reduce latency, redundant representation is used superiorly, as well as the use of a minimum redundancy factor.Division and square root can be integrated into one unit which causes a reduction in hardware cost. With 40 nm technology library, the area of our architecture after layout design, is 37795μm^2, the power is 81.19 m W and the delay is only 656 ps. The cycles for double-precision division and square root are 17 and 16, respectively. Experiments show our architecture achieves small latency and high frequency,together with modest area and power. | PENG Yuanxi CHEN Jiyang LEI Yuanwu HE Tingting DENG Ziye | 2017 | Chinese Journal of Electronics2017，26，1： | 1 |
| 5 | Pipelined Range Reduction Based Truncated Multiplier显示文摘Range reduction is the initial and essential stage of function computation,but its pipelined implementation has the drawbacks of large cost and terrible accuracy.We proposed low cost and accurate pipelined range reduction,which adopts truncated multiplier with optimized bit-width to reduce the cost of pipelined implementation and achieve the accuracy within 1 unit in the last place(ulp).TCORDIC algorithm is a widely used algorithm to compute floating-point sine/cosine function,and we implemented the combination of TCORDIC and our range reduction algorithms,verifying the goal of accuracy within 1 ulp. | ZHU Baozhou LEI Yuanwu PENG Yuanxi | 2019 | Chinese Journal of Electronics2019，28，6： | 0 |
| 6 | High-Performance FP Divider with Sharing Multipliers Based on Goldschmidt Algorithm显示文摘Focused on the issue that division is complex and needs a long latency to compute,a method to design the unit of high-performance Floating-point(FP)divider based on Goldschmidt algorithm was proposed.Bipartite reciprocal tables were adopted to obtain initial value of iteration with area-saving,and parallel multipliers were employed in the iteration unit to reduce latency.FP divider to support pipeline execution with the control of state machine is presented to increase the throughput.The design was implemented in Digital signal process(DSP)chip by sharing the existed multipliers. | HE Tingting CHEN Jiyang LEI Yuanwu PENG Yuanxi ZHU Baozhou | 2017 | Chinese Journal of Electronics2017，26，2： | 0 |
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