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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Continuous exposure to bisphenol A during in vitro follicular development induces meiotic abnormalities 显示文摘 | Lenie S Cortvrindt R Eichenlaub -Ritter U | 2008 | Mutat Res2008，651，12： | 1 |
| 3 | Incidence and risk factors for agranulocytosis in Latin American countries—the Latin Study显示文摘 | Nelson Hamerschlak Eliane Maluf Alexandre Biasi Cavalcanti álvaro Avezum Júnior José Eluf-Neto Roberto Passeto Falc?o Irene Gyongyvér Heidemarie Lorand-Metze Daniel Goldenberg Cézar Leite Santana Daniela de Oliveira Werneck Rodrigues Leny Nascimento da Mo | 2008 | European Journal of Clinical Pharmacology2008，，9： | 1 |
| 4 | Epizootiological aspects of Streptococcus iniae affecting tilapia in Texas显示文摘 | Petra R P Johnson S K Lenis D H | 1997 | Aquac1997，152，14： | 1 |
| 5 | Quantitative analysis of adhesion molecules on cellular constituents of the human uterine microenvironment under the influence of estrogen and progesterone显示文摘 | Brackin M N Cruse J M Lenis R E | 2002 | Exp Mol Pathol2002，72，2： | 1 |
| 6 | Case-based reasoning adaptation of numerical representations of human organs by interpo- lation 显示文摘 | HENRIET J LENI P E LAURENT R | 2014 | Expert Systems with Applications2014，41，2： | 1 |
| 7 | A comparison of the efficacies and duration of action of the angiotensin II receptor blockers telmisartan and amlodipine显示文摘 | Lacourcière Y Lenis J Orchard R | 1998 | Blood Press Monit1998，3，5： | 1 |
| 8 | Artrial fibrillation:the therapeutic options显示文摘 | Lenis R V | 1990 | Drugs1990，40，6： | 1 |
| 9 | A comparison of the efficacies and duration of action of the angiotensin Ⅱ recep tot blockers telmisartan and amlodipine显示文摘 | Lacourciere Y Lenis J R Orchard | 1998 | Blood PressMonit1998，3，： | 1 |
| 10 | Continuous exposure to bisphenol A during in vitro follicular development induces mei- otic abnormalities 显示文摘 | LENIE S CORTVRINDT R SMITZ J | 2008 | Mutat Res2008，651，12： | 1 |
| 11 | Con-tinuous exposure to bisphenol A during in vitro follicular de-velopment induces meiotic abnormalities显示文摘 | Lenie S Cortvrindt R Eichenlaub-Ritter U Smitz J | 2008 | Mutat Res2008，651，12： | 1 |
| 12 | AAIsafeR limits ventricular pacing in unselected patients显示文摘 | Pioger G Leny G Nitzsch6 R | 2007 | Pacing Clin Electrophysiol2007，30，1： | 1 |
| 13 | AAIsafeR limits ventricular pacing in unselected patients显示文摘 | Pioger G Leny G Nitzsche R | | 0，，： | 1 |
| 14 | AAISafeR limits ventricular pacing in unselected patients 显示文摘 | Pioger G Leny G Nitzsche R | 2007 | PACE2007，30，： | 1 |
| 15 | Insulin-like growth factor binding protein-4 protease produced by smooth muscle cell increases in the coronary artery after angioplasty显示文摘 | BAYES-GENIS A SCHRARTZ R S LENIS D A | 2001 | J Arterioscler Thromb Vasc Biol2001，21，： | 1 |
| 16 | The unfavorable nature of preoperative delirium in elderly hip fractured patients显示文摘 | ADUNSKY A LENY R HEIM M | 2003 | Arch Gerontol Geriatr2003，36，1： | 1 |
| 17 | Continuous exposure to bisphenol A during in vitro follicular development induces meiotic abnormalities 显示文摘 | Lenie S Cortvrindt R Eichenlaub-Ritter U | 2008 | Mutat Res2008，65，： | 1 |
| 18 | AAIsafeR limits ventricular pacing in unselected patients 显示文摘 | PIOGER G LENY G NITZSCH R | 2007 | Pacing Clin Electr- ophysiol2007，30，1： | 1 |
| 19 | A comparison of the efficacies and duration of action of the angiotensin Ⅱ receptor blockers telmisartan and amlodipine显示文摘 | Lacourciere Y Lenis J Orchard R | 1998 | J Blood Press Monit1998，3，5： | 1 |
| 20 | AAI safe R limits vemricular pacing in unselected patients显示文摘 | Pioger G Leny G Nitzsche R | 2007 | PACE2007，30，1： | 1 |
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