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| 1 | Mucosal healing progression after acute colitis in mice显示文摘BACKGROUND Mucosal healing has become a therapeutic goal to achieve stable remission in patients with inflammatory bowel diseases. To achieve this objective, overlapping actions of complex cellular processes, such as migration, proliferation, and differentiation, are required. These events are longitudinally and tightly controlled by numerous factors including a wide range of distinct regulatory proteins. However, the sequence of events associated with colon mucosal repair after colitis and the evolution of the luminal content characteristics during this process have been little studied.AIM To document the evolution of colon mucosal characteristics during mucosal healing using a mouse model with chemically-induced colitis.METHODS C57 BL/6 male mice were given 3.5% dextran sodium sulfate(DSS) in drinking water for 5 d. They were euthanized 2(day 7), 5(day 10), 8(day 13), and 23(day28) d after DSS removal. The colonic luminal environment and epithelial repair processes during the inflammatory flare and colitis resolution were analyzed with reference to a non-DSS treated control group, euthanized at day 0. Epithelial repair events were assessed histo-morphologically in combination with functional permeability tests, expression of key inflammatory and repairing factors, and evaluation of colon mucosa-adherent microbiota composition by 16 S rRNA sequencing.RESULTS The maximal intensity of colitis was concomitant with maximal alterations of intestinal barrier function and histological damage associated with goblet cell depletion in colon mucosa. It was recorded 2 d after termination of the DSStreatment, followed by a progressive return to values similar to those of control mice. Although signs of colitis were severe(inflammatory cell infiltrate, crypt disarray, increased permeability) and associated with colonic luminal alterations(hyperosmolarity, dysbiosis, decrease in short-chain fatty acid content), epithelial healing processes were launched early during the inflammatory flare with increased gene expression of certain key epithelial repair modulators, including transforming growth factor-β, interleukin(Il)-15, Il-22, Il-33, and serum amyloid A. Whereas signs of inflammation progressively diminished, luminal colonic environment alterations and microscopic abnormalities of colon mucosa persisted long after colitis induction.CONCLUSION This study shows that colon repair can be initiated in the context of inflamed mucosa associated with alterations of the luminal environment and highlights the longitudinal involvement of key modulators. | Sandra Vidal-Lletjós Mireille Andriamihaja Anne Blais Marta Grauso Patricia Lepage Anne-Marie Davila Claire Gaudichon Marion Leclerc Francois Blachier Annaig Lan | 2019 | World Journal of Gastroenterology2019，25，27： | 5 |
| 2 | Effect of forcefeedback treatments in patients with chronic motor deficits after a stroke显示文摘 | Bourbonnais D Bilodeau S Lepage Y | 2002 | Am J Phys Med Rehabil2002，81，12： | 1 |
| 3 | Minisatellite polymorphism as a tool to distinguish closely related Lactococcus lactis strains显示文摘 | QUENEE P LEPAGE E KIM W S | 2005 | FEMS Microbiol Lett2005，248，： | 1 |
| 4 | Human mes- enchymal stem ceils provide protection against radiation - induced liv- er injury by antioxidative process, vasculature protection, hepatocyte differentiation, and trophic effects显示文摘 | Francois S Mouiseddine M Allenet - Lepage B | 2013 | Biomed Res Int2013，2013，15： | 1 |
| 5 | A soft chemistry approach to coating of LiFePO4 with a conducting polymer 显示文摘 | LEPAGE D MICHOT C LIANG G X GAUTHIER M SCHOUGAARD S B | 2011 | Angew Chem Int Ed2011，50，： | 1 |
| 6 | Incidence andpatterns of recurrence after resection for cure of colonic cancer in awell defined population显示文摘 | MANFREDI S BOUVIER AM LEPAGE C | 2006 | Br J Surg2006，93，9： | 1 |
| 7 | Early shrinkage development in a high performance concrete显示文摘 | Lepage S Balbaki M Dallaire E | 1999 | Cement Concrete and Aggreagtes1999，21，2： | 1 |
| 8 | Epidemiology and manage-ment of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 9 | MFG-E8 released by apoptotic endothelial ceils triggers anti-inflammatory mac- rophage reprogramming 显示文摘 | Brissette MJ Lepage S Lamonde AS | 2012 | PLoS One2012，7，36： | 1 |
| 10 | Epidemiology and management of liver metastases from colorectal cancer显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 11 | Epidemiology and management of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，： | 1 |
| 12 | Incidence and patterns of recurrence after resection for cure of colonic cancer in a well defined population显示文摘 | Manfredi S Bouvier AM Lepage C | | 0，，09： | 1 |
| 13 | Epidemiology and man- agement of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C el al | 2006 | Ann Surg2006，244，2： | 1 |
| 14 | Epidemiology and manage- ment of liver metastases from colorectal cancer 显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 15 | Prediction of risk of in-hospital geriatric complications in older patients with hip fracture显示文摘 | DE BRAUWER I LEPAGE S YOMBI J C | 2012 | Aging Clin Exp Res2012，24，1： | 1 |
| 16 | Epidemiology and management of liver metastases from colorectal cancer显示文摘 | Manfredi S Lepage C Hatem C | 2006 | Ann Surg2006，244，2： | 1 |
| 17 | Lung cancer that harbors an HER2 mutation: epidemiologie characteristics and therapeutic perspectives 显示文摘 | Mazieres J Peters S Lepage B | 2013 | J Clin Oncol2013，31，16： | 1 |
| 18 | Early Shrinkage Development in the High Performance Concrete显示文摘 | LEPAGE S BALBAKI M DALLAIRE E | 1999 | Cement Concrete and Aggregates1999，，2： | 1 |
| 19 | Neu- ral correlates of dual task interference in rapid visual streams: An fMRI study显示文摘 | MARCANTONI W S LEPAGE M BEAUDOIN G | 2003 | Brain and Cognition2003，53，2： | 1 |
| 20 | Lung cancer that har- bors an HER2 mutation: epidemiologic characteristics and therapeutic perspectives 显示文摘 | Mazires J Peters S Lepage B | 2013 | J Clin Oncol2013，31，16： | 1 |
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