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| 1 | Radiofrequency ablation for early oesophageal squamous neoplasia:Outcomes form United Kingdom registry显示文摘AIM:To report outcomes on patients undergoing radiofrequency ablation(RFA)for early oesophageal squamous neoplasia from a National Registry.METHODS:A Prospective cohort study from 8 tertiary referral centres in the United Kingdom.Patients with squamous high grade dysplasia(HGD)and early squamous cell carcinoma(ESCC)confined to the mucosa were treated.Visible lesions were removed by endoscopic mucosal resection(EMR)before RFA.Following initial RFA treatment,patients were followed up 3monthly.Residual flat dysplasia was treated with RFA until complete reversal dysplasia(CR-D)was achieved or progression to invasive Squamous cell cancer defined as infiltration into the submucosa layer or beyond.The main outcome measures were CR-D at 12 mo from start of treatment,long term durability,progression to cancer and adverse events.RESULTS:Twenty patients with squamous HGD/ESCC completed treatment protocol.Five patients(25%)had EMR before starting RFA treatment.CR-D was 50%at12 mo with a median of 1 RFA treatment,mean 1.5(range 1-3).Two further patients achieved CR-D with repeat RFA after this time.Eighty per cent with CR-D remain dysplasia free at latest biopsy,with median follow up 24 mo(IQR 17-54).Six of 20 patients(30%)progressed to invasive cancer at 1 year.Four patients(20%)required endoscopic dilatations for symptomatic structuring after treatment.Two of these patients have required serial dilatations thereafter for symptomatic dysphagia with a median of 4 dilatations per patient.The other 2 patients required only a single dilatation to achieve an adequate symptomatic response.One patient developed cancer during follow up after end of treatment protocol.CONCLUSION:The role of RFA in these patients re-mains unclear.In our series 50%patients responded at12 mo.These figures are lower than limited published data. | Rehan J Haidry Mohammed A Butt Jason Dunn Matthew Banks Abhinav Gupta Howard Smart Pradeep Bhandari Lesley Ann Smith Robert Willert Grant Fullarton Morris John Massimo Di Pietro Ian Penman Marco Novelli Laurence B Lovat | 2013 | World Journal of Gastroenterology2013，19，36： | 7 |
| 2 | Psychosocial factors and their association with reflux oesophagitis,Barrett's oesophagus and oesophageal adenocarcinoma显示文摘AIM:To investigate the role of psychological characteristics as risk factors for oesophageal adenocarcinoma(OAC),as well as the reflux-mediated precursor pathway.METHODS:An all-Ireland population-based case-control study recruited 230 reflux oesophagitis(RO),224 Barrett's oesophagus(BO) and 227 OAC patients and 260 controls.Each case/control group completed measures of stress,depression,self-efficacy,self-esteem,repression and social support.A comparative analysis was undertaken using polytomous logistic regression adjusted for potential confounders.RESULTS:Compared to controls,OAC patients were almost half as likely to report high stress levels over their lifetime(P = 0.010,OR 0.51;95%CI:0.29-0.90)and 36% less likely to report having experienced depression(OR 0.64;95%CI:0.42-0.98).RO patients reported significantly higher stress than controls particularly during middle-and senior-years(P for trends < 0.001).RO patients were 37% less likely to report having been highly emotionally repressed(OR 0.63;95%CI:0.41-0.95).All case groups(OAC,RO and BO) were more likely than controls to report having had substantial amounts of social support(OR 2.84;95%CI:1.63-4.97;OR 1.97;95%CI:1.13-3.44 and OR 1.83;95%CI:1.03-3.24,respectively).CONCLUSION:The improved psychological profile of OAC patients may be explained by response shift.The role of psychological factors in the development of OAC requires further investigation. | Paul Denver Michael Donnelly Liam J Murray Lesley A Anderson | 2013 | World Journal of Gastroenterology2013，19，11： | 5 |
| 3 | Risk factors for Barrett’s oesophagus and oesophageal adenocarcinoma:Results from the FINBAR study显示文摘AIM:To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.METHODS:This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients,227 oesophageal adenocarcinoma patients and 260 controls.All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.RESULTS:Gastro-oesophageal reflux was associated with Barrett's [OR 12.0(95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48(95% CI 2.25-5.41)].Oesophageal adenocarcinoma patients were more likely than controls to be ex-or current smokers [OR 1.72(95% CI 1.06-2.81)and OR 4.84(95% CI 2.72-8.61)respectively] and to have a high body mass index [OR 2.69(95% CI 1.62-4.46)].No significant associations were observed between these risk factors and Barrett's oesophagus.Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50(95% CI 0.30-0.86)].CONCLUSION:A high body mass index,a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma. | Lesley A Anderson RG Peter Watson Seamus J Murphy Brian T Johnston Harry Comber Jim Mc Guigan John V Reynolds Liam J Murray | 2007 | World Journal of Gastroenterology2007，13，10： | 5 |
| 4 | Have patients with esophagitis got an increased risk of adenocarcinoma? Results from a population-based study显示文摘AIM: To examine an increased risk of esophageal adenocarcinoma is restricted to patients who develop Barrett's esophagus or whether esophagitis per se is a risk factor for adenocarcinoma.METHODS: A population-based cohort of patients with histological evidence of esophagitis without Barrett's esophagus was constructed using electronic pathology reports relating to all esophageal biopsies in Northern Ireland between 1993 and 1996. Person-years of followup and incident cases of esophageal cancer were calculated by linking the cohort to death files and the Northern Ireland Cancer Registry records. Standardized incidence ratios (SIR) were calculated for esophageal cancers (adenocarcinoma, squamous cell carcinoma (SCC), and histologically unspecified cancers).RESULTS: A total of 2 013 patients in the cohort provided 13 559 patient-years of follow-up (mean follow-up 6.7 years). None of the patients developed adenocarcinoma. Three patients developed SCC, and six developed histologically unspecified cancers. The SIR for all esophageal cancers and for SCC were 2.73 (95%CI 1.25-5.19) and 2.93 (95%CI 0.61-8.59), respectively. In a sensitivity analysis in which all unspecified esophageal cancers were treated as adenocarcinomas, the SIR for adenocarcinoma was 2.64 (0.97-5.75).CONCLUSION: The risk of adenocarcinoma is not elevated in patients with histological evidence of esophagitis without Barrett's esophagus; however, these patients may have a moderately increased risk of SCC.Further studies are required to confirm these findings,which suggest that Barrett's esophagus, not esophagitis,is the key precursor lesion in the development of adenocarcinoma. | Seamus J Murphy Lesley A Anderson Brian T Johnston Deirdre A Fitzpatrick Peter RG Watson Pauline Monaghan Liam J Murray | 2005 | World Journal of Gastroenterology2005，11，46： | 4 |
| 5 | Human cord blood-derived cells can differentiate into hepatocytes in the mouse liver with no evidence of cellular fusion显示文摘 | Philip N Newsome Ingolfur Johannessen Shelagh Boyle Evangelos Dalakas Karen A Mcaulay Kay Samuel Frances Rae Lesley Forrester Marc L Turner Peter C Hayes David J Harrison Wendy A Bickmore John N Plevris | 2003 | Gastroenterology2003，，7： | 2 |
| 6 | Prevalence of chronic kidney disease in the united States显示文摘 | Coresh J Selvin E Lesley A | 2007 | JAMA2007，298，17： | 1 |
| 7 | Genetic and physiological influences on the alkenone/alkenoate versus growth temperature relationship in Emiliania huxleyi and Gephyrocapsa oceanica 显示文摘 | Conte M H Thompson A Lesley D | 1998 | Geochimica et Cosmochimica Acta1998，62，1： | 1 |
| 8 | A new equation to estimate glomerular filtration rare显示文摘 | Level MD Lesley A Stevens MD | 2009 | Ann Imern Meal2009，150，9： | 1 |
| 9 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotropha 显示文摘 | Lesley A R Van Niel E W J Torremans R A M | 1998 | Appl Eviron Microbiol1998，54，： | 1 |
| 10 | A comparison of fill density obtained by supplementing cold lateral condensation with ultrasonic condensation 显示文摘 | Alexander K Frederick R Lesley A | 2002 | J Endod2002，28，9： | 1 |
| 11 | Enhancement of Finserprints in Blood Part 3 :Reactive Tech- niques, Acid Yellow and Process Sequences, Journal of Foren- sic Identification显示文摘 | Vaughn G Sears Butcher Colin P G Fitzgerald Lesley A | 2005 | 55(6):7412005，55，6： | 1 |
| 12 | Recombinant Factor VIIa:a view of its use in congenital or acquired haemophilia and othee congenital bleeding disorders显示文摘 | Asif M Siddiqui A Lesley J | 2005 | Drugs2005，65，8： | 1 |
| 13 | Asset Allocation and the Euro Factor显示文摘 | DAVID S P LESLEY A P | 1999 | Journal of Financial Planning1999，12，2： | 1 |
| 14 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 15 | Triple-negative breast cancers are increased in black women regardless of age or body mass index 显示文摘 | Lesley A Stead Timothy L Lash Jerome E Sobieraj | 2009 | Breast Cancer Res2009，11，2： | 1 |
| 16 | Thiosphaera Pantotropha gen nov sp nov, a Facultative Autotrophic Sulphur Bacterium显示文摘 | Lesley A Robertson L A Kuenen J G | 1983 | J Gen Microbiol1983，129，8： | 1 |
| 17 | Information seeking and anxiety among colonoscopy-na?ve adults: direct-to-colonoscopy vs traditional consult-first pathways显示文摘AIM To investigate the effects of direct to colonoscopy pathways on information seeking behaviors and anxiety among colonoscopy-na?ve patients.METHODS Colonoscopy-na?ve patients at two tertiary care hospitals completed a survey immediately prior to their scheduled outpatient procedure and before receiving sedation.Survey items included clinical pathway(direct or consult),procedure indication(cancer screening or symptom investigation),telephone and written contact from the physician endoscopist office,information sources,and pre-procedure anxiety.Participants reported pre-procedure anxiety using a 10 point scale anchored by 'very relaxed'(1) and 'very nervous'(10).At least three months following the procedure,patient medical records were reviewed to determine sedative dose,procedure indications and any adverse events.The primary comparison was between the direct and consult pathways.Given the very different implications,a secondary analysis considering the patient-reported indication for the procedure(symptoms or screening).Effects of pathway(direct vs consult) were compared both within and between the screening and symptom subgroups.RESULTS Of 409 patients who completed the survey,34% followed a direct pathway.Indications for colonoscopy were similar in each group.The majority of the participants were women(58%),married(61%),and internet users(81%).The most important information source was family physicians(Direct) and specialist physicians(Consult).Use of other information sources,including the internet(20% vs 18%) and Direct family and friends(64% vs 53%),was similar in the Direct and Consult groups,respectively.Only 31% of the 81% who were internet users accessed internet health information.Most sought fundamental information such as what a colonoscopy is or why it is done.Pre-procedure anxiety did not differ between care pathways.Those undergoing colonoscopy for symptoms reported greater anxiety [mean 5.3,95%CI: 5.0-5.7(10 point Likert scale)] than those for screening colonoscopy(4.3,95%CI: 3.9-4.7).CONCLUSION Procedure indication(cancer screening or symptom investigation) was more closely associated with information seeking behaviors and pre-procedure anxiety than care pathway. | Jocelyn A Silvester Harmandeep Kalkat Lesley A Graff John R Walker Harminder Singh Donald R Duerksen | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 1 |
| 18 | Lipid in an Antarctic food chain: Calanus, Bolinopsi 显示文摘 | Clarke A Lesley J H Hopkins C C E | 1987 | Beroe Sarsia1987，72，： | 1 |
| 19 | Metabolic pathway of anaerobic ammonium oxidation on the basis of 15N studies in a fluidized bed reactor显示文摘 | Astrid A van de Graaf Peter de Bruijn Lesley A Robertson et d | 1997 | Microbiology1997，143，7： | 1 |
| 20 | Determination of quinolones and fluoroquinolones in fish tissue and seafoof by high - performance liquid chromatography with electrospay ionisation tandum mass spectrometric detection显示文摘 | LESLEY J LINDSEY A | 2002 | Journal of Chromatography A2002，982，： | 1 |
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