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| 1 | Panitumumab and irinotecan versus irinotecan alone for patients with KRAS wild-type, fluorouracil-resistant advanced colorectal cancer (PICCOLO): a prospectively stratified randomised trial显示文摘 | Matthew T Seymour Sarah R Brown Gary Middleton Timothy Maughan Susan Richman Stephen Gwyther Catherine Lowe Jennifer F Seligmann Jonathan Wadsley Nick Maisey Ian Chau Mark Hill Lesley Dawson Stephen Falk Ann O’Callaghan Kim Benstead Philip Chambers Alfred | 2013 | Lancet Oncology2013，，8： | 6 |
| 2 | Novel p19 protein engages IL-12 p40 to form a cytokine from a cytokine,IL-23,with biological activites similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，1： | 1 |
| 3 | CD44 and its interaction with extracellular matrix显示文摘 | Lesley J Hyman R Kincade PW | 1993 | Adv Immunol1993，54，： | 1 |
| 4 | Hydrogen peroxide mediates amyloid β-protein toxicity显示文摘 | Behl C Davis JB Lesley R Schubert D | 1994 | Cell1994，77，6： | 1 |
| 5 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 6 | Simultaneous nitrification and denitrification in aerobic chemostat cultures of Thiosphaera pantotropha 显示文摘 | Lesley A R Van Niel E W J Torremans R A M | 1998 | Appl Eviron Microbiol1998，54，： | 1 |
| 7 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 8 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，5： | 1 |
| 9 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23,with biological activities similar as well as distinct from IL-12显示文摘 | Oppmann B Lesley R Blom B | 2000 | J Exp Med2000，13，5： | 1 |
| 10 | The structures of five new antifungal and hemolytic amphidinol analogs from Amphidinium carterae collected in New Zealand显示文摘 | REIKO E LESLEY R YASSUKATSU O | 2005 | Harmful Algae2005，4，： | 1 |
| 11 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | OPPMANN B LESLEY R BLOM B | 2000 | Immunity2000，13，5： | 1 |
| 12 | Novel p19 protein enga ges IL-12p40 to form a cytokine, IL-23, with biological activi ties similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 13 | Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats显示文摘 | Megan R D Lesley C F Violetta MG | 2008 | Exp Neurol2008，212，2： | 1 |
| 14 | A comparison of fill density obtained by supplementing cold lateral condensation with ultrasonic condensation 显示文摘 | Alexander K Frederick R Lesley A | 2002 | J Endod2002，28，9： | 1 |
| 15 | Novel p19 protein engages IL-12p40 to form a cytokine,IL-23 ,with biological activities simi lar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，： | 1 |
| 16 | Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12 显示文摘 | Oppmann B Lesley R Blom B | 2000 | Immunity2000，13，5： | 1 |
| 17 | Hydrogen peroxide mediates amyloid Bprotein toxicity显示文摘 | Davis JB Lesley R | 1994 | Cell1994，77，： | 1 |
| 18 | Hydrogen peroxide mediates amyloid beta proteintoxicity显示文摘 | Behl C Davis JB Lesley R | 1994 | Cell1994，77，6： | 1 |
| 19 | BAI 3, CDX 2 and VIL 1: a panel of three antibodies to distinguish small cell from large cell neuroendocrine lung carcinomas显示文摘 | Muhammad F Bari Helen Brown Andrew G Nicholson Keith M Kerr John R Gosney William A Wallace Irshad Soomro Salli Muller Danielle Peat Jonathan D Moore Lesley A Ward Maxim B Freidin Eric Lim Manu Vatish David R J Snead | 2014 | Histopathology2014，，： | 1 |
| 20 | Information seeking and anxiety among colonoscopy-na?ve adults: direct-to-colonoscopy vs traditional consult-first pathways显示文摘AIM To investigate the effects of direct to colonoscopy pathways on information seeking behaviors and anxiety among colonoscopy-na?ve patients.METHODS Colonoscopy-na?ve patients at two tertiary care hospitals completed a survey immediately prior to their scheduled outpatient procedure and before receiving sedation.Survey items included clinical pathway(direct or consult),procedure indication(cancer screening or symptom investigation),telephone and written contact from the physician endoscopist office,information sources,and pre-procedure anxiety.Participants reported pre-procedure anxiety using a 10 point scale anchored by 'very relaxed'(1) and 'very nervous'(10).At least three months following the procedure,patient medical records were reviewed to determine sedative dose,procedure indications and any adverse events.The primary comparison was between the direct and consult pathways.Given the very different implications,a secondary analysis considering the patient-reported indication for the procedure(symptoms or screening).Effects of pathway(direct vs consult) were compared both within and between the screening and symptom subgroups.RESULTS Of 409 patients who completed the survey,34% followed a direct pathway.Indications for colonoscopy were similar in each group.The majority of the participants were women(58%),married(61%),and internet users(81%).The most important information source was family physicians(Direct) and specialist physicians(Consult).Use of other information sources,including the internet(20% vs 18%) and Direct family and friends(64% vs 53%),was similar in the Direct and Consult groups,respectively.Only 31% of the 81% who were internet users accessed internet health information.Most sought fundamental information such as what a colonoscopy is or why it is done.Pre-procedure anxiety did not differ between care pathways.Those undergoing colonoscopy for symptoms reported greater anxiety [mean 5.3,95%CI: 5.0-5.7(10 point Likert scale)] than those for screening colonoscopy(4.3,95%CI: 3.9-4.7).CONCLUSION Procedure indication(cancer screening or symptom investigation) was more closely associated with information seeking behaviors and pre-procedure anxiety than care pathway. | Jocelyn A Silvester Harmandeep Kalkat Lesley A Graff John R Walker Harminder Singh Donald R Duerksen | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，19： | 1 |
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