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| 1 | Applications of endoscopic ultrasound in pancreatic cancer显示文摘Since the introduction of endoscopic ultrasound guided fine-needle aspiration(EUS-FNA),EUS has assumed a growing role in the diagnosis and management of pancreatic ductal adenocarcinoma(PDAC).The objective of this review is to discuss the various applications of EUS and EUS-FNA in PDAC.Initially,its use for detection,diagnosis and staging will be described.EUS and EUS-FNA are highly accurate modalities for detection and diagnosis of PDAC,this high accuracy,however,is decreased in specific situations particularly in the presence of chronic pancreatitis.Novel techniques such as contrast-enhanced EUS,elastography and analysis of DNA markers such as k-ras mutation analysis in FNA samples are in progress and might improve the accuracy of EUS in the detection of PDAC in this setting and will be addressed.EUS and EUS-FNA have recently evolved from a diagnostic to a therapeutic technique in the management of PDAC.Significant developments in therapeutic EUS have occurred including advances in celiac plexus interventions with direct injection of ganglia and improved pain control,EUS-guided fiducial and brachytherapy seed placement,fine-needle injection of intra-tumoral agents and advances in EUS-guided biliary drainage.The future role of EUS and EUS in management of PDAC is still emerging. | Leticia Perondi Luz Mohammad Ali Al-Haddad Michael Sai Lai Sey John M DeWitt | 2014 | World Journal of Gastroenterology2014，20，24： | 5 |
| 2 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 3 | S-adenosyl-methionine decreases ethanol-induced apoptosis in primary hepatocyte cultures by a c-Jun N-terminal kinase activity-independent mechanism显示文摘AIM:To determine the role of c-Jun N-terminal kinase(JNK)activity in ethanol-induced apoptosis and themodulation of this signaling cascade by S-Adenosyl-methionine(AdoMet).METHODS:Primary hepatocyte cultures werepretreated with 100 μmol/L SP600125,a selective JNKinhibitor,1 mL/L DMSO or 4 mmol/L AdoMet and thenexposed to 100 mmo/L ethanol.Hepatocyte apoptosiswas determined by the TUNEL and DNA ladder assays.JNK activity and its inhibition by SP600125 and AdoMetwere determined by Western blot analysis of c-junphosphorylation and Bid fragmentation.SP600125 andAdoMet effects on the apoptotic signaling pathway weredetermined by Western blot analysis of cytochrome crelease and pro-caspase 3 fragmentation.The AdoMeteffect on glutathione levels was measured by Ellman'smethod and reactive oxygen species(ROS)generationby cell cytometry.RESULTS:The exposure of hepatocytes to ethanolinduced JNK activation,c-jun phosphorylation,Bidfragmentation,cytochrome c release and pro-caspase 3cleavage;these effects were diminished by SP600125,and caused a significant decrease in ethanol-inducedapoptosis(P<0.05).AdoMet exerted an antioxidanteffect maintaining glutathione levels and decreasing ROSgeneration,without a significant effect on JNK activity,and prevented cytochrome c release and pro-caspase 3cleavage. CONCLUSION:The JNK signaling cascade is a keycomponent of the proapoptotic signaling pathwayinduced by ethanol.JNK activation may be independentfrom ROS generation,since AdoMet which exertedantioxidant properties did not have a significant effect onJNK activity.JNK pathway modulator agents and AdoMetmay be components of promising therapies for alcoholicliver disease(ALD)treatment. | Maria del Pilar Cabrales-Romero Lucrecia Márquez-Rosado Samia FatteI-Fazenda Cristina Trejo-Solis Evelia Arce-Popoca Leticia Alemán-Lazarini Saúl Villa-Trevineo | 2006 | World Journal of Gastroenterology2006，12，12： | 2 |
| 4 | Determination of ethanol and specific gravity in gasoline by distillation curves and multivariate analysis显示文摘 | Alemea H G Leticia M | 2009 | Talanta2009，78，45： | 1 |
| 5 | Antioxidant and antimicrobial effects of phenolic compounds extracts of Northeast Portugal honey 显示文摘 | LETICIA E ANA P P LEANDRO M | 2008 | Food and Chemical Toxicology2008，46，： | 1 |
| 6 | Extraction of high-quality, melanin-free RNA from Mycosphaerella fijiensis for cDNA preparation显示文摘 | Ignacio Islas-Flores Leticia Peraza-Echeverría Blondy Canto-Canché Cecilia Mónica Rodríguez-García | 2006 | Molecular Biotechnology2006，，1： | 1 |
| 7 | Pharmacodynamic modeling of Carbapenems and Fluoroquinolones against bacteria that produce extended-spectrum beta-lactamases显示文摘 | LETICIA R M PHARM D CHRISTOPHER R F | 2004 | Clinical Therapeuncs2004，26，： | 1 |
| 8 | Relationship marketing and information and communication technologies:Analysis of retail travel agencies显示文摘 | Leticia S A Ana M D M Rodolfo V C (2007) | 2007 | Journal of Travel Research2007，，： | 1 |
| 9 | Transesterification of soybean oil catalyzed by sulfated zirconia 显示文摘 | CAMILA M G SERGIO T LETICIA L M | 2008 | Bioresour Technol2008，99，： | 1 |
| 10 | Use of factorial design for optimizationof microwave-assisted digestion of lubricating oil显示文摘 | LETICIA M COSTA SERGIO L C FERREIRA ANARITA A Nogueira | 2005 | BrazChem Soc2005，16，6： | 1 |
| 11 | Antioxidant and antim- icrobial effects of phenolic compounds extracts of Northeast Portugal honey 显示文摘 | Leticia E Ana PP Leandro M | 2008 | Food Chem Toxicol2008，46，12： | 1 |
| 12 | Multi-enzylne production By pure and mixed cultures of Saccharomyces and Non-saccharomyces yeasts during wine ferlnentation显示文摘 | PAOLA MATURANO Y LETICIA A RODRIGUEZ ASSAF EUGENIA M TORO | 2012 | International Journal of Food Microbiology2012，，155： | 1 |
| 13 | The brand management system and service firm competitiveness in thought leadership in brand management显示文摘 | VIJANDE S LETICIA M LANZA D R | 2013 | Journal of Business Research2013，66，2： | 1 |
| 14 | Reusing of a hide waste for leather fafliquoring显示文摘 | Santos Leticia M Cutterres M | 2007 | Journal of Cleaner Production2007，15，： | 1 |
| 15 | Removal of marine plankton by photocata- lysts with Aurivillius-type structure显示文摘 | Obreg6n Alfaro S Martfnez-de la Cruz A~ Torres-Martfnez Leticia M | 2010 | Catalysis Communi- cation2010，11，： | 1 |
| 16 | Selective antimicrobial action of chitosan against spoilage yeasts in mixed culture fermentations显示文摘 | Leticia G R Blanca I E A Guadalupe M A U | 2004 | Journal of Industrial Microbiology and Biotechnology2004，31，1： | 1 |
| 17 | Parathyroid Hormone secretion and action: evidence for discrete receptors for the carboxyl-terminal region and related biological actions of carboxyl-terminal Ligands 显示文摘 | Timothy M Murray Leticia G Rao Paola Divieti | 2005 | Endocrine Reviews2005，26，1： | 1 |
| 18 | Prediction of water and protein contents and quality classification of Spanish cooked ham using NIR hyperspectral imaging显示文摘 | PAU T LETICIA M NOHA M | 2013 | Journal of Food Engineering2013，117，3： | 1 |
| 19 | p53 mutations in nasal natural killer /Tcell lymphoma from Mexico: association with large cell morphology and advanced disease显示文摘 | LETICIA Q M MARCUS K GISELA K | 2001 | Am J Pathol2001，159，： | 1 |
| 20 | Effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios 显示文摘 | Sandeep M Leticia T Reynaldo P | 2007 | General and Comparative Endocrinology2007，150，3： | 1 |
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