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	题名	作者	年代	出处	被引量
1	An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。	Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley	2014	Cell Research2014，24，7：	10
2	Performance of long rectangular barrettes in granitic saprolites 显示文摘	Ng C W W Lei G H	2003	Journal of Geotechnical and Geoenvironmental Engineering America Society of Civil Engineers2003，129，8：	1
3	Laser cladding of stainless steel with Ni-Cr3C2 for improved wear performance 显示文摘	Zhang D W Lei T C Li F J	2001	Wear2001，，251：	1
4	An analytical solution for consolidation with vertical drains under multi-romp loading显示文摘	LEI G H ZHENG Q NG C W W	2015	G6otechnique2015，65，7：	1
5	Tribological behavior of fullerenestyrene sulfonic acid copolymer as water-based lubricant additive显示文摘	Lei H Guan W C Luo J B	2002	Wear2002，252，：	1
6	查看详情显示文摘	Yan L W Duan X R Ding X T Dong J Q Yang Q W Liu Y Zou X L Liu D Q Xuan W M Chen L Y Rao J Song X M Huang Y Mao W C Wang Q M Li Q Cao Z Li B Cao J Y Lei G J Zhang J H Li X D Chen W Cheng J Cui C H Cui Z Y Deng Z C Dong Y B Feng B B Gao Q D Han X Y Hong W Y		0，，：	1
7	An approximate ana- lytical solution for calculating ground surface settle- ments due to diaphragm walling 显示文摘	Lei G H Sun H S Ng C W W	2014	Computers and Geotechnics2014，61，：	1
8	Ammonium removal from aqueous solutions using microwave-treated natural Chinese zeolite显示文摘	Lei L C Li X J Zhang X W	2008	Separation and Purification Technology2008，58，：	1
9	Soil surface evaporation processes under mulches of different sized gravel 显示文摘	Yuan C P Lei T W Mao L L	2009	Catena2009，，2：	1
10	Construction of anovel Pichia pastoris cell-surface display systembased on the cell wall protein Pirl显示文摘	Qingjie W Lei L Min C	2008	Current Micro-biology2008，56，：	1
11	Influence of de electric current on the hardness of thermally aged Cu-Cr-Zr alloy 显示文摘	Wang Z J Zhong Y B Cao G H Wang C Wang J Ren W L Lei Z S Ben Z M	2009	Journal of Alloys and Compounds2009，479，：	1
12	Independent maternal origin of Chinese swamp buffalo (Bubalus bubalis) 显示文摘	Lei C Z Zhang W Chen H	2007	Anita Genet2007，38，2：	1
13	Preparation and photoluminescence of highly ordered TiO2 nanowire arrays 显示文摘	LEI Y ZHANG L D MENG G W LI G H ZHANG X Y LIANG C H CHEN W WANG S X	2001	Applied Physics Letters2001，78，8：	1
14	Computer-aided kidney seg- mentation on abdominal CT images 显示文摘	LIN D T LEI C C HUNG S W	2006	IEEE Trans on In- formation Technology in Biomedicine2006，10，1：	1
15	Use of tung oil as a reactive tough- ening agent indieyelopentadiene - terminated unsaturated poly- ester resins 显示文摘	Liu C Lei W Cai Z	2013	Industrial Crops and Products2013，49，：	1
16	Influences of grass and moss on runoff and sediment yield on sloped loess surfaces under simulated rainfall 显示文摘	PAN C Z SHANGGUAN Z P LEI T W	2006	Hydrological Processes2006，20，18：	1
17	The effects of heat treatment on microstructure and erosion properties of laser surface-clad Ni-base alloy 显示文摘	Zhang D W Lei T C Zhang J G	1999	Surface Coating Technology1999，，115：	1
18	An explicit analytical solution for calculating horizontal stress changes and displacements around an excavated diaphragm wall panel 显示文摘	Ng C W W Lei G H	2003	Canadian Geotechnical Journal2003，40，4：	1
19	Disposable microfluidic device with ultraviolet detection for highly resolved screening of illicit drugs显示文摘	QIANG W ZHAI C LEI J	2009	Analyst2009，134，9：	1
20	Study on population genetic charac- teristics of Qinchuan cows using microsatellite markers显示文摘	Sun W Chen H Lei C	2007	J Genet Genomics2007，34，1：	1

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