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| 1 | Preparation and activity evaluation of NiMoB/-Al_2O_3 catalyst by liquid-phase furfural hydrogenation显示文摘Amorphous MoNiB/ -Al 2 O 3 alloy catalysts were prepared by reducing NiCl 2 ·6H 2 O and (NH 4 ) 6 Mo 7 O 24 ·4H 2 O supported on -Al 2 O 3 with NaBH 4 as reducing agent. Using liquid-phase hydro-genation of furfural (FFR) as a probe reaction, the activity of MoNiB/ -Al 2 O 3 was examined. Compared to NiB and NiMoB, NiMoB/ -Al 2 O 3 exhibited excellent activity and selectivity towards furfuryl alcohol (FFA). After reaction for 3.0 h at 80 ℃ and 5.0 MPa in methanol, FFR conversion reached 99% with FFA yield of 91%. The effects of doping amount of Mo and calcination temperature before NaBH 4 reduction on hydrogenation activity were also investigated. The optimum Mo/Ni atom ratio and calcination temperature were found to be 1:7 and 300 ℃, respectively. XRD patterns and SEM images indicated that NiMoB over the surface of -Al 2 O 3 was amorphous and highly dispersed, which was responsible for the high thermal stability of the title catalyst. | Shuqin Wei Hongyou Cui Jinghua Wang Shuping Zhuo Weiming Yi Lihong Wang Zhihe Li | 2011 | Particuology2011，9，1： | 7 |
| 2 | The Calculation of Ampere Force on Electric Power Transformer under the Short Circuit Situation显示文摘 | Liyang Jiao Baodong Bai Hongyou Li | 2008 | ICEMS2008，，： | 1 |
| 3 | Plasma spray forming of FGM mould显示文摘 | ZHAO Ziyu FANG Jiancheng LI Hongyou | 2005 | Transactions of Nonferrous Metal Society of China2005，15，2： | 1 |
| 4 | Immune response induced by hematoporphyrin derivatives mediated photodynamic therapy:Immunogenic cell death and elevated costimulatory molecules显示文摘Photodynamic therapy(PDT)not only destroys tumor cells directly but also induced anti-tumor immune response through damage-associated molecular patterns(DAMPs).It is reported that anti-tumor response was associated with light dose and photosensitizer used in PDT.In this study,4T1 tumor cells were implanted on both the right and left flanks of mice.Only the right tumor was treated by HpD-PDT,while the left tumor was not irradiated.The anti-tumor immune response induced by HpD-PDT was investigated.The expression of DAMPs and costimulatory molecules induced by HpD-PDT were tested by immuno fluorescence and flow cytometry in vivo.Different light doses of PDT were designed to treat 4T1 cells.The killing effect was assessed by CCK-8 kit and apoptosis kit.The expression of DAMPs on 4T1 cells after HpDPDT were evaluated by flow cytometry,western blot and ATP kit.This study showed that CD4^(+)T,CD8^(+)T and the production of IFN-γwere increased significantly on day 10 in righttumor after PDT treatment compared with control group.HpD-PDT enhanced the expression of calreticulin(CRT)on tumor tissue.Importantly,co-stimulatory molecular OX-40 and 4-1BB were elevated on CD8^(+)T cells.In vitro,immunogenic death of 4T1 cells was induced after PDT.Besides,the expression of DAMPs increased with the increasing of energy density.This study indicates that anti-tumor immune effect was induced by HpD-PDT.The knowledge of the involvement of CRT,ATP and co-stimulatory molecules uncovers important mechanistic insight into the anti-tumor immunogenicity.It was the first time that co-stimulatory molecules were investigated and found to elevate after PDT. | Shan Long Yibing Zhao Yuanyuan Xu Hui Li Hongyou Zhao Defu Chen Jing Zeng Haixia Qiu Xiaosong Li Ying Gu | 2022 | Journal of Innovative Optical Health Sciences2022，15，4： | 1 |
| 5 | The Calculation of Ampere Force on Electric Power Transformer under the Short Circuit Situation显示文摘 | Liyang Jiao Baodong Bai Hongyou Li | 2008 | ICEMS2008，，： | 1 |
| 6 | Comparative Metabolomics Analysis between Red- and White-Flowered Common Buckwheat Cultivars显示文摘Common buckwheat(Fagopyrum esculentum),a specialty crop in southwest China,is not only used as a supplement to primary grain crops but also to produce beverages,such as tea and wine.To fully exploit the products made from common buckwheat flower,ultra-performance liquid chromatography–electrospray ionization–tandem mass spectrometry(UPLC–ESI–MS/MS)was conducted to analyze the metabolites in red-(‘Guihong 2’)and white-flowered(‘Fengtian 1’)buckwheat cultivars.A total of 784 metabolites were identified of which flavonoids were the largest group with 191 components,followed by organic acids and derivatives(126),and amino acids and derivatives(95).Besides,dozens of phenylpropanoids,nucleotides and derivates,lipids,alkaloids as well as several kinds of indole derivatives and sterides were detected.Among these rich varieties of metabolites,24 metabolites were only detected in the red flower that mainly included 8 anthocyanins and 6 flavones,while 22 metabolites were only detected in the white flower,which mainly contained 5 lipids,5 flavonoids,and 5 organic acids and derivatives.Our results enrich the metabolites’information of buckwheat and may be helpful for the exploitation of products from common buckwheat flowers. | Jiao Deng Fen Dong Chaoxin Wu Jiali Zhao Hongyou Li Juan Huang Taoxiong Shi Ziye Meng Fang Cai Qingfu Chen Pingfang Yang | 2021 | Phyton-International Journal of Experimental Botany2021，90，3： | 0 |
| 7 | Anti-PD1 antibody and not anti-LAG-3 antibody improves the antitumor effect of photodynamic therapy for treating metastatic breast cancer显示文摘Photodynamic therapy(PDT)has limited effects in treating metastatic breast cancer.Immune checkpoints can deplete the function of immune cells;however,the expression of immune checkpoints after PDT is unclear.This study investigates whether the limited e±cacy of PDT is due to upregulated immune checkpoints and tries to combine the PDT and immune checkpoint inhibitor to observe the e±cacy.A metastatic breast cancer model was treated by PDT mediated by hematoporphyrin derivatives(HpD-PDT).The anti-tumor effect of HpD-PDT was observed,as well as CD4þT,CD8þT and calreticulin(CRT)by immunohistochemistry and immunofluorescence.Immune checkpoints on T cells were analyzed byflow cytometry after HpD-PDT.When combining PDT with immune checkpoint inhibitors,the antitumor effect and immune effect were assessed.For HpD-PDT at 100 mW/cm2 and 40,60 and 80 J/cm2,primary tumors were suppressed and CD4þT,CD8þT and CRT were elevated;however,distant tumors couldn't be inhibited and survival could not be prolonged.Immune checkpoints on T cells,especially PD1 and LAG-3 after HpD-PDT,were upregulated,which may explain the reason for the limited HpD-PDT effect.After PDT combined with anti-PD1 antibody,but not with anti-LAG-3 antibody,both the primary and distant tumors were signi-cantly inhibited and the survival time was prolonged,additionally,CD4þT,CD8þT,IFN-þCD4þT and TNF-þCD4þT cells were signi-cantly increased compared with HpD-PDT.HpD-PDT could not combat metastatic breast cancer.PD1 and LAG-3 were upregulated after HpD-PDT.Anti-PD1 antibody,but not anti-LAG-3 antibody,could augment the antitumor effect of HpD-PDT for treating metastatic breast cancer. | Shan Long Yibing Zhao Yuanyuan Xu Bo Wang Haixia Qiu Hongyou Zhao Jing Zeng Defu Chen Hui Li Jiakang Shao Xiaosong Li Ying Gu | 2024 | Journal of Innovative Optical Health Sciences2024，17，1： | 0 |
| 8 | A Model for the Connectivity of Horizontal Wells in Water-Flooding Oil Reservoirs显示文摘As current calculation models for inter-well connectivity in oilfields can only account for vertical wells,an updated model is elaborated here that can predict the future production performance and evaluate the connectivity of horizontal wells(or horizontal and vertical wells).In this model,the injection-production system of the considered reservoir is simplified and represented with many connected units.Moreover,the horizontal well is modeled with multiple connected wells without considering the pressure loss in the horizontal direction.With this approach,the production performance for both injection and production wells can be obtained by calculating the bottom-hole flowing pressure and oil/water saturation according to the material balance equation and a saturation front-tracking equation.Some effort is also provided to optimize(to fit known historical production performances)the two characteristic problem parameters,namely,the interwell conductivity and connected volume by means of a SPSA gradient-free algorithm.In order to verify the validity of the model,considering a heterogenous reservoir,three conceptual examples are constructed,where the number ratio between injection and production wells are 1/4,4/1 and 4/5,respectively.It is shown that there is a high consistency between simulation results and field data. | Chenyang Shi Fankun Meng Hongyou Zhang HuiJiang Chang Xun Zhong Jie Gong and Fengling Li | 2022 | Fluid Dynamics & Materials Processing2022，18，5： | 0 |
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