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| 1 | Value of circulating cell-free DNA in diagnosis of hepatocelluar carcinoma显示文摘AIM:To investigate the value of combined detection of circulating cell-free DNA(cfDNA),a-fetal protein(AFP) and a L-fucosidase(AFU) for diagnosis of hepatocellular carcinoma(HCC).METHODS:Serum samples from 39 HCC patients and 45 normal controls were collected.Branched DNA(bDNA) was used to detect the level of cfDNA,and a receiver operating characteristic curve was employed to evaluate the diagnostic sensitivity,specificity,accuracy,positive predictive value,negative predictive value,positive likelihood ratio,negative likelihood ratio and Youden index,and to assess the diagnostic efficiency and their correlations with the clinicopathological features.AFP and AFU were detected by chemiluminescence and colorimetry,respectively.The significance of combined detection of the three biomarkers was discussed.RESULTS:cfDNA level was increased in 22 of the 39 HCC samples and in 2 of the 45 normal controls.cfDNA level in HCC samples was significantly higher than that in normal controls(P < 0.05).There were significant differences in sex and extra-and intrahepatic metastasis(P < 0.05).There was no significant correlation between cfDNA,AFP and AFU in the detection of HCC.The sensitivity of combined detection of cfDNA with one marker(AFP or AFU) and cfDNA with two markers(AFP and AFU) was 71.8%,87.2% and 89.7% vs 56.4%,53.8% and 66.7% for cfDNA,AFP and AFU used alone,respectively,the difference being statistically significant(P < 0.05).CONCLUSION:Quantitative analysis of cfDNA is sensitive and feasible,and the combined detection of cfDNA with AFP or AFU or both could improve the diagnostic sensitivity for HCC. | Ken Chen Hong Zhang Li-Na Zhang Shao-Qing Ju Jing Qi Dong-Feng Huang Feng Li Qun Wei Jing Zhang | 2013 | World Journal of Gastroenterology2013，19，20： | 16 |
| 2 | Roles of Rap1 signaling in tumor cell migration and invasion显示文摘Ras-associated protein-1(Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions(e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate(GTP) or guanosine diphosphate(GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression. | Yi-Lei Zhang Ruo-Chen Wang Ken Cheng Brian Z.Ring Li Su | 2017 | Cancer Biology & Medicine2017，14，1： | 8 |
| 3 | Impact of adjustment measures on reducing outpatient waiting time in a community hospital: application of a computer simulation显示文摘是的背景耐心的满足的一个重要决定因素,等待的时间,在护理服务的地里获得了增加的注意。试图说明在一所社区医院里等待时间的分发特征并且探索潜力的影响的现在的学习测量减少基于一条计算机模拟途径等待时间的门诊病人。方法在 2006 在一个一个月期间学习经期,代表性的研究在位于上海的一所社区医院里被进行,中国。等待时间的门诊病人的基线数据根据登记时间和支付时间的记录被计算。一种模拟技术被采用在减少等待的时间上调查观点改革方法的影响。从 10 092 个病人和 26 816 医药咨询的一个总数的结果数据在学习被收集, 19 947 医药咨询被包括。这所医院里的门诊病人的全部的访问时间的一般水准是在早上,在下午的 19.1 分钟,和 34.3 分钟的 43.6 分钟因为整个天学习了时期。模拟结果建议门诊病人的那等待的时间能极大地通过约会系统和根据在工作日的不同时间等待的病人的数字安排的灵活面向要求的医生的介绍被减少。一个约会系统的结论采纳和医生安排的灵活管理可以是完成减少的等待的时间的有效方法。 | CHEN Bai-lian LI En-dong Kazunobu Yamawuchi Ken Kato Shinji Naganawa MIAO Wei-jun | 2010 | Chinese Medical Journal2010，，5： | 5 |
| 4 | Gait Definition and Successive Gait-transition Method Based on Energy Consumption for a Quadruped显示文摘In nature,to realize the smooth motion for different speeds,the continuous gait transition is usually required for the quadrupeds.Thus,the gait simulation of quadrupeds is a requisite step to obtain the stable and energy-efficient gait for the walking machines.In this paper,the definitions of the two gait parameters,phasic difference and duty factor are presented,which can determine the gait of the quadrupeds.Then,several typical gaits of the quadrupeds are analyzed such that the seven standard gaits and corresponding parameters are summarized.Additionally,the variance law of the two parameters,which determine the relationship of gait transition,is analyzed.Furthermore,the quadruped gait derivative spectrum (QGDS) is proposed and the gait definition of the quadrupeds is presented.To minimize the power consumption,the choice criterion of gait,the optimal gait in terms of the motion speed,duty factory,and power consumption for the walking machines,is developed.Last,the continuous variance of the gait is implemented by the simulation of the gait transition from walk to trot,which evaluate the choice criterion and transition of gait. | ZHAO Danpu XU Jing WU Dan CHEN Ken LI Chengrong | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 5 |
| 5 | CABYR binds to AKAP3 and Ropporin in the human sperm fibrous sheath显示文摘钙绑定酷氨酸调整 phosphorylation 的蛋白质(CABYR ) 是高度多态的钙绑定 tyrosine-/threonine-phosphorylated 和 serine-/threonine-phosphorylated 涉及 capacitation 的含纤维的鞘(FS ) 蛋白质。一个通常认为的领域(氨基酸 12 鈥 ? 8 ) 对类型 II 营地依赖者蛋白质 kinase A (RII ) dimerisation 和抛锚 kinase 蛋白质(AKAP ) 的规章的子单元相应在 N 终点的蛋白质 kinase A 的有约束力的领域建议那 CABYR 可以自我装配并且绑在 AKAP。而且,有证据, CABYR 与 AKAP 限制了相互作用。然而,推进在 CABYR 之间的证据和新关系,包括 AKAP,另外的 FS 蛋白质将在理解 FS 的基本生理学是有用的。在这研究,为不可溶解的蛋白质的 co-immunoprecipitation 的新策略,以及在有集体 spectrometry 和西方的污点的联合的标准 co-immunoprecipitation 方法,被采用探索在 CABYR, AKAP3 和 Ropporin 之间的关系。结果证明 AKAP3 是有由 anti-CABYR-A polyclonal 抗体的 CABYR 的 co-immunoprecipitated,并且,相反地, CABYR 也是有由 anti-AKAP3 polyclonal 抗体的 AKAP3 的 co-immunoprecipitated。包含蛋白质的另一象 RII 一样域, Ropporin,也是有 CABYR 的 co-immunoprecipitated,显示 Ropporin 是 CABYR 的绑定之一合伙。在 CABYR, AKAP3 和 Ropporin 之间的相互作用被酵母证实二混血儿的试金。进一步的分析显示出那 CABYR 不仅由它的 RII 领域绑在 AKAP3 而且除象 RII 一样领域以外通过另外的区域绑在 Ropporin。这是 CABYR 变体形成的第一示范不仅有 scaffolding 蛋白质 AKAP3 而且与在人的精子 FS 的另一象 RII 一样包含域的蛋白质的建筑群。 | Yan-Feng Li Wei He Arabinda Mandal Young-Hwan Kim Laura Digilio Ken Klotz Charles J Flickinger John C Herr | 2011 | Asian Journal of Andrology2011，13，2： | 5 |
| 6 | Blastic Plasmacytoid Dendritic Cell Neoplasm:Progress in Cell Origin,Molecular Biology,Diagnostic Criteria and Therapeutic Approaches显示文摘Blastic plasmacytoid dendritic cell neoplasm(BPDCN)is a rare hematological malignancy characterized by recurrent skin nodules,an aggressive clinical course with rapid involvement of hematological organs,and a poor prognosis with poor overall survival.BPDCN is derived from plasmacytoid dendritic cells(pDCs)and its pathogenesis is unclear.The tumor cells show aberrant expression of CD4,CD56,interleukin-3 receptor alpha chain(CD 123),blood dendritic cell antigen 2(BDCA 2/CD303),blood dendritic cell antigen 4(BDCA4)and transcription factor(E protein)E2-2(TCF4).The best treatment drugs are based on experience by adopting those used for either leukemia or lymphoma.Relapse with drug resistance generally occurs quickly.Stem cell transplantation after the first complete remission is recommended and tagraxofusp is the first targeted therapy.In this review,we summarize the differentiation of BPDCN from its cell origin,its connection with normal pDCs,clinical characteristics,genetic mutations and advances in treatment of BPDCN.This review provides insights into the mechanisms of and new therapeutic approaches for BPDCN. | Wei CHENG Tian-tian YU Ai-ping TANG Ken HE YOUNG Li YUI | 2021 | Current Medical Science2021，41，3： | 4 |
| 7 | Freestanding hierarchical porous carbon film derived from hybrid nanocellulose for high-power supercapacitors显示文摘Nanocellulose 是从可更新的生物资源导出的持续、 eco 友好的 nanomaterial。在这研究,我们利用了 nanocellulose 的二种类型的结构的优点并且为 supercapacitors 作为电极材料制作了独立使碳化的混合 nanocellulose 电影。长纤维素 nanofibrils (CNF ) 形成了一个 macroporous 框架,并且短纤维素 nanocrystals 在 CNF 框架附近被装配并且产生了 micro/mesopores。因为扔的薄原子层(ALD ) ,这二水平的层次多孔的结构成功地在碳化期间被保存艾尔 2 O 3 保角的涂层,它有效地阻止了 nanocellulose 的聚集。这些使碳化,部分, graphitized nanocellulose 纤维被互连,与 1,244 m 2 敢愠 ?? 敤摡攠摮的一个大特定的表面区域形成一个综合、高度传导性的网络吗? | Zhi Li Kaveh Ahadi Keren Jiang Behzad Ahvazi Peng Li Anthony O. Anyia Ken Cadien Thomas Thundat | 2017 | Nano Research2017，10，5： | 2 |
| 8 | HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression显示文摘Diffuse large B-cell lymphoma(DLBCL) is an aggressive type of non-Hodgkin’s lymphoma. A total of 10%-15% of DLBCL cases are associated with myelocytomatosis viral oncogene homolog(MYC) and/or B-cell lymphoma-2(BCL2) translocation or amplification. BCL2 inhibitors have potent anti-tumor effects in DLBCL;however, resistance can be acquired through up-regulation of alternative anti-apoptotic proteins. The histone deacetylase(HDAC) inhibitor chidamide can induce BIM expression, leading to apoptosis of lymphoma cells with good efficacy in refractory recurrent DLBCL. In this study, the synergistic mechanism of chidamide and venetoclax in DLBCL was determined through in vitro and in vivo models. We found that combination therapy significantly reduced the protein levels of MYC, TP53, and BCL2 in activated apoptotic-related pathways in DLBCL cells by increasing BIM levels and inducing cell apoptosis. Moreover, combination therapy regulated expression of multiple transcriptomes in DLBCL cells, involving apoptosis, cell cycle, phosphorylation, and other biological processes, and significantly inhibited tumor growth in DLBCL-bearing xenograft mice. Taken together, these findings verify the in vivo therapeutic potential of chidamide and venetoclax combination therapy in DLBCL, warranting pre-clinical trials for patients with DLBCL. | Cancan LUO Tiantian YU Ken H.YOUNG Li Yu | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，8： | 2 |
| 9 | Tribulusamide A and B, New Hepatoprotective Lignanamides from the Fruits of Tribulus terrestris: Indications of Cytoprotective Activity in Murine Hepatocyte Culture显示文摘 | Jian-Xin Li Qin Shi Quan-Bo Xiong Jeevan Prasain Yasuhiro Tezuka Toru Hareyama Zheng-Tao Wang Ken Tanaka Tsuneo Namba Shigetoshi Kadota | 1998 | Planta Med1998，，07： | 2 |
| 10 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 11 | CD8 + T Cells That Produce Interleukin-17 Regulate Myeloid-Derived Suppressor Cells and Are Associated With Survival Time of Patients With Gastric Cancer显示文摘 | Yuan Zhuang Liu–Sheng Peng Yong–Liang Zhao Yun Shi Xu–Hu Mao Weisan Chen Ken C. Pang Xiao–Fei Liu Tao Liu Jin–Yu Zhang Hao Zeng Kai–Yun Liu Gang Guo Wen–De Tong Yan Shi Bin Tang Na Li Shu Yu Ping Luo Wei–Jun Zhang Dong–Shui Lu Pei–Wu Yu Quan–Ming Zou | 2012 | Gastroenterology2012，，4： | 2 |
| 12 | Light-induced irreversible structural phase transition in trilayer graphene显示文摘A crystal structure has a profound influence on the physical properties of the corresponding material.By synthesizing crystals with particular symmetries,one can strongly tune their properties,even for the same chemical configuration(compare graphite and diamond,for instance).Even more interesting opportunities arise when the structural phases of crystals can be changed dynamically through external stimulations.Such abilities,though rare,lead to a number of exciting phenomena,such as phase-change memory effects.In the case of trilayer graphene,there are two common stacking configurations(ABA and ABC)that have distinct electronic band structures and exhibit very different behaviors.Domain walls exist in the trilayer graphene with both stacking orders,showing fascinating new physics such as the quantum valley Hall effect.Extensive efforts have been dedicated to the phase engineering of trilayer graphene.However,the manipulation of domain walls to achieve precise control of local structures and properties remains a considerable challenge.Here,we experimentally demonstrate that we can switch from one structural phase to another by laser irradiation,creating domains of different shapes in trilayer graphene.The ability to control the position and orientation of the domain walls leads to fine control of the local structural phases and properties of graphene,offering a simple but effective approach to create artificial two-dimensional materials with designed atomic structures and electronic and optical properties. | Jianyu Zhang Jinsen Han Gang Peng Xi Yang Xiaoming Yuan Yongjun Li Jianing Chen Wei Xu Ken Liu Zhihong Zhu Weiqi Cao Zheng Han Jiayu Dai Mengjian Zhu Shiqiao Qin Kostya S.Novoselov | 2020 | Light(Science & Applications)2020，9，1： | 2 |
| 13 | Infection complications in febrile chimeric antigen receptor(CAR)-T recipients during the peri-CAR-T cell treatment period examined using metagenomic next-generation sequencing(mNGS)显示文摘Dear Editor,Chimeric antigen receptor-engineered(CAR)-T cell therapy has achieved unprecedented efficacy on refractory/relapsed B-cell malignancies[1].Yet,CAR-T recipients are highly susceptible to infection due to the immunodeficiency caused by B-cell aplasia and the pretreatment with chemotherapy.However,due to the systematic use of empirical broad-spectrum antibiotics and immunosuppressors to control cytokine release syndrome(CRS)reaction,microbiological diagnosis of infection has remained challenging in CAR-T recipients. | Jiali Nie Li Yang Liang Huang Lili Gao Ken He Young Jehane Michael Le Grange Xingcheng Yang Jia Wei Min Xiao Jianfeng Zhou | 2022 | Cancer Communications2022，42，5： | 2 |
| 14 | Carbon nanosheets derived from reconstructed lignin for potassium and sodium storage with low voltage hysteresis显示文摘Lignin is the second most abundant and the only nature polymer rich in aromatic units.Although aromatic-unit-rich precursors often yield soft carbon after carbonization,the side chains in lignin crosslink with the aromatic units and form a rigid three-dimensional(3D)structure which eventually leads to hard carbons.Through a graphene oxide-catalyzed decomposition and repolymerization process,we successfully reconstructed lignin by partially tailoring the side chains.Compared to directly carbonized lignin,the carbonized reconstructed lignin possesses significantly fewer defects,86%fewer oxygen-functionalities,82%fewer micropores,and narrower interlayer space.These parameters can be tuned by the amount of catalysts(graphene oxide).When tested as anode for K-ion and Na-ion batteries,the carbonized reconstructed lignin delivers notably higher capacity at low-potential range(especially for Na-storage),shows much-improved performance at high current density,and most importantly,reduces voltage hysteresis between discharge and charge process by more than 50%,which is critical to the energy efficiency of the energy storage system.Our study reveals that the voltage hysteresis in K-storage is much severer than that in Na-storage for all samples.For practical K-ion battery applications,the voltage hysteresis deserves more attention in future electrode materials design and the reconstruct ion strategy introduced in this work provides potential low-cost solution. | Keren Jiang Xuehai Tan Shengli Zhai Ken Cadien Zhi Li | 2021 | Nano Research2021，14，12： | 2 |
| 15 | Absorption characteristics of highpower disc fiber laser by side pumping of laser diode显示文摘 | Nam Seong Kim Mahendra Prabhu Cheng Li Jie Song Deyuan Shen and Ken ichi Ueda | 1999 | Lasers and Electro Optics1999，3，9： | 1 |
| 16 | Fractionation of a light crude oil and identification and quantitation of aliphatic, aro- matic,and biomarker compounds by GC-FID and GC MS显示文摘 | WANG Zhendi FINGAS M F LI Ken | 1994 | Journal of Chromatographic Science1994，32，9： | 1 |
| 17 | Durability of PEM fuel cell cathode in the presence of Fe3+ and Al3+显示文摘 | Li Hui Tsay Ken Wang Haijiang | 2010 | Journal of Power Sources2010，195，： | 1 |
| 18 | Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers显示文摘 | Ramaswamy Govindan Li Ding Malachi Griffith Janakiraman Subramanian Nathan D. Dees Krishna L. Kanchi Christopher A. Maher Robert Fulton Lucinda Fulton John Wallis Ken Chen Jason Walker Sandra McDonald Ron Bose David Ornitz Donghai Xiong Ming You David J. | 2012 | Cell2012，，： | 1 |
| 19 | Sustainable Ammonia Synthesis from Nitrogen and Water by One-Step Plasma Catalysis显示文摘Sustainable ammonia synthesis at ambient conditions that relies on renewable sources of energy and feedstocks is globally sought to replace the Haber-Bosch process.Here,using nitrogen and water as raw materials,a nonthermal plasma catalysis approach is demonstrated as an effective powerto-chemicals conversion strategy for ammonia production.By sustaining a highly reactive environment,successful plasma-catalytic production of NH_(3) was achieved from the dissociation of N_(2) and H_(2)O under mild conditions.Plasma-induced vibrational excitation is found to decrease the N_(2) and H_(2)O dissociation barriers,with the presence of matched catalysts in the nonthermal plasma discharge reactor contributing significantly to molecular dissociation on the catalyst surface.Density functional theory calculations for the activation energy barrier for the dissociation suggest that ruthenium catalysts supported on magnesium oxide exhibit superior performance over other catalysts in NH_(3) production by lowering the activation energy for the dissociative adsorption of N_(2) down to 1.07 eV.The highest production rate,2.67 mmol gcat.^(-1) h^(-1),was obtained using ruthenium catalyst supported on magnesium oxide.This work highlights the potential of nonthermal plasma catalysis for the activation of renewable sources to serve as a new platform for sustainable ammonia production. | Tianqi Zhang Renwu Zhou Shuai Zhang Rusen Zhou Jia Ding Fengwang Li Jungmi Hong Liguang Dou Tao Shao Anthony B.Murphy Kostya(Ken)Ostrikov Patrick J.Cullen | 2023 | Energy & Environmental Materials2023，6，2： | 1 |
| 20 | Phytochemicalsand antioxidant properties of solvent extracts from Japonica rice bran显示文摘 | Phoency Lai Ken Yuon Li Shin Lu | 2009 | Food Chemistry2009，117，3： | 1 |
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