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| 1 | Secondary Metabolites of a Deep Sea Derived Fungus Aspergillus versicolor CXCTD-06-6a and Their Bioactivity显示文摘In order to obtain novel secondary metabolites, a deep sea inhabiting fungus Aspergillus versicolor CXCTD-06-6a was investigated. One new diketopiperazine brevianamide W(1a), as well as five known diketopiperazine alkaloids, diketopiperazine V(1b), brevianamide Q(2), brevianamide R(3), brevianamide K(4), and brevianamide E(5), were isolated from the Et OAc extract of the fermentation broth. Their structures were elucidated by spectroscopy techniques(NMR, MS). The six compounds exhibited moderate radical scavenging activity against DPPH with clearance ratio of 55.0%(1a and 1b), 53.7%(2), 46.2%(3), 61.4%(4) and 19.3%(5) at a concentration of 13.9 μmol L-1, respectively; while the positive control ascorbic acid showed a ratio of 70.3% at the concentration of 28.4 μmol L-1. | KONG Xianglan CAI Shengxin ZHU Tianjiao GU Qianqun LI Dehai LUAN Yepeng | 2014 | Journal of Ocean University of China2014，13，4： | 3 |
| 2 | De novo sequencing and comparative analysis of the blueberry transcriptome to discover putative genes related to antioxidants显示文摘 | Xiaoyan Li Haiyue Sun Jiabo Pei Yuanyuan Dong Fawei Wang Huan Chen Yepeng Sun Nan Wang Haiyan Li Yadong Li | 2012 | Gene2012，，1： | 1 |
| 3 | Cytotoxic metabolites from the antarctic psychrophilic fungus Oidiodendron truncatum显示文摘 | LI LIYUAN LI DEHAI LUAN YEPENG | | 0，，： | 1 |
| 4 | The design and realization of tracking robot based on MCS-51 显示文摘 | WANG Li YAO Yepeng MA Guoqiang | 2009 | Journal of Capital Normal University: Natural Science Edition2009，30，1： | 1 |
| 5 | Tunicamycin suppresses cisplatin-induced HepG2 cell apoptosis via enhancing p53 protein nuclear export显示文摘 | ZHANG Lijuan LI Zaiquan YANG Yepeng | 2009 | Molecular Cell Biochemistry2009，327，： | 1 |
| 6 | Age-dependent decreases in DNA methyltransferase levels and low transmethylation micronutrient levels synergize to promote overexpression of genes implicated in autoimmunity and acute coronary syndromes显示文摘 | LI Yepeng LIU Ying STRICKLAND F M | 2010 | Exp Gerontol2010，45，： | 1 |
| 7 | Multi-source genesis of continental carbonate-rich fine-grained sedimentary rocks and hydrocarbon sweet spots显示文摘This paper systematically discusses the multiple source characteristics and formation mechanisms of carbonate-rich fine-grained sedimentary rocks through the analysis of material source and rock formation.The hydrocarbon accumulation characteristics of carbonate-rich fine-grained sedimentary rocks are also summarized.The results show that the main reason for the enrichment of fine-grained carbonate materials in rift lake basins was the supply of multiple material sources,including terrestrial material input,formation of intrabasinal authigenic carbonate,volcanic-hydrothermal material feeding and mixed source.The development of carbonate bedrock in the provenance area controlled the filling scale of carbonate materials in rift lake basins.The volcanic-hydrothermal activity might provide an alkaline fluid to the lake basins to strengthen the material supply for the formation of carbonate crystals.Authigenic carbonate crystals induced by biological processes were the main source of long-term accumulation of fine-grained carbonate materials in the lake basins.Carbonate-rich fine-grained sedimentary rocks with multiple features were formed through the interaction of physical,biochemical and chemical processes during the deposition and post-deposition stages.The source and sedimentary origin of the fine-grained carbonate rock controlled the hydrocarbon accumulation in it.In the multi-source system,the types of'sweet spots'of continental shale oil and gas include endogenous type,terrigenous type,volcanic-hydrothermal type and mixed source type. | JIANG Zaixing KONG Xiangxin YANG Yepeng ZHANG Jianguo ZHANG Yuanfu WANG Li YUAN Xiaodong | 2021 | Petroleum Exploration and Development2021，48，1： | 0 |
| 8 | Lack of interferon regulatory factor 3 leads to anxiety/depression-like behaviors through disrupting the balance of neuronal excitation and inhibition in mice显示文摘Disrupting the balance of neuronal excitation and inhibition (E/I) is an important pathogenic mechanism of anxiety and depression. Interferon regulatory factor 3 (IRF3) plays a key role in the innate immune response, and activation of IRF3 triggers the expression of type I interferons and downstream interferon-stimulated genes, which are associated with anxiety and depression. However, whether IRF3 participates in the pathogenesis of anxiety/depression by regulating E/I balance remains poorly understood. Here, we reported that global knockout (KO) of IRF3 (IRF3^(−/−)) significantly increased anxiety/depression-like behaviors, but did not affect normal spatial learning and memory. Compared with wild type (WT) control mice, the E/I balance was disrupted, as reflected by enhanced glutamatergic transmission and decreased GABAergic transmission in the neurons of hippocampal CA1 and medial prefrontal cortex (mPFC) in IRF3-KO mice. Importantly, genetic rescue of IRF3 expression by adeno-associated virus (AAV) was sufficient to alleviate anxiety/depression-like behaviors and restore the neuronal E/I balance in IRF3-KO mice. Taken together, our results indicate that IRF3 is critical in maintaining neuronal E/I balance, thereby playing an essential role in ensuring emotional stability. | Junjie Li Yayan Pang Yehong Du Lei Xia Mulan Chen Yepeng Fan Zhifang Dong | 2023 | Genes & Diseases2023，10，3： | 0 |
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