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| 1 | Estimation of carbon sinks in chemical weathering in a humid subtropical mountainous basin显示文摘The fluvial geochemistry of the mainstream and tributaries of the Zengjiang River was investigated,and the mass balance approach and deduction methods were used to estimate the uptake of atmospheric CO2 through rock chemical weathering.The results showed that the chemical runoff mainly consisted of HCO3-,Ca2+,Na+,and dissolved Si,and that silicate mineral weathering was significant,but carbonate mineral weathering was a minor source of dissolved loads in the Zengjiang River basin because of the low amount of interlayered carbonate rock strata in the catchment.The ion composition indicated that atmospheric CO2 was the primary erosive agent for rock chemical weathering in the Zengjiang River basin.The CO2 consumption fluxes caused by rock chemical weathering were(3.50-3.81) × 105 mol km-2 a-1,which is just lower than that in tropical and subtropical basalt and carbonate regions,and is much higher than that in temperate and cold-temperate regions,indicating that surficial chemical weathering processes in the humid and hot monsoon current influencing the low-middle latitude zone of the Northern Hemisphere constitutes a significant carbon sink in the global biogeochemical cycle. | TAO Zhen GAO QuanZhou WANG ZhenGang ZHANG ShengHua XIE ChenJi LIN PeiSong RUAN XiaoBing LI ShuHong MAO HaiRuo | 2011 | Chinese Science Bulletin2011，56，35： | 15 |
| 2 | Chitosan hydrogel incorporated with dental pulp stem cell-derived exosomes alleviates periodontitis in mice via a macrophage-dependent mechanism显示文摘Periodontitis is caused by host immune-inflammatory response to bacterial insult.A high proportion of proinflammatory macrophages to anti-inflammatory macrophages leads to the pathogenesis of periodontitis.As stem cell-derived exosomes can modulate macrophage phenotype,dental pulp stem cell-derived exosomes(DPSC-Exo)can effectively treat periodontitis.In this study,we demonstrated that DPSC-Exo-incorporated chitosan hydrogel(DPSC-Exo/CS)can accelerate the healing of alveolar bone and the periodontal epithelium in mice with periodontitis.Gene Ontology(GO)term enrichment analysis showed that treatment with DPSC-Exo/CS ameliorated periodontal lesion by suppressing periodontal inflammation and modulating the immune response.Specifically,DPSC-Exo/CS facilitated macrophages to convert from a pro-inflammatory phenotype to an anti-inflammatory phenotype in the periodontium of mice with periodontitis,the mechanism of which could be associated with miR-1246 in DPSC-Exo.These results not only shed light on the therapeutic mechanism of DPSCExo/CS but also provide the basis for developing an effective therapeutic approach for periodontitis. | Zongshan Shen Shuhong Kuang Yong Zhang Mingmei Yang Wei Qin Xuetao Shi Zhengmei Lin | 2020 | Bioactive Materials2020，5，4： | 14 |
| 3 | Cytocompatibility with osteogenic cells and enhanced in vivo anti-infection potential of quaternized chitosan-loaded titania nanotubes显示文摘Infection is one of the major causes of failure of orthopedic implants. Our previous study demonstrated that nanotube modification of the implant surface, together with nanotubes loaded with quaternized chitosan(hydroxypropyltrimethyl ammonium chloride chitosan, HACC), could effectively inhibit bacterial adherence and biofilm formation in vitro. Therefore, the aim of this study was to further investigate the in vitro cytocompatibility with osteogenic cells and the in vivo anti-infection activity of titanium implants with HACC-loaded nanotubes(NT-H). The titanium implant(Ti), nanotubes without polymer loading(NT), and nanotubes loaded with chitosan(NT-C) were fabricated and served as controls. Firstly, we evaluated the cytocompatibility of these specimens with human bone marrow-derived mesenchymal stem cells in vitro.The observation of cell attachment, proliferation, spreading, and viability in vitro showed that NT-H has improved osteogenic activity compared with Ti and NT-C. A prophylaxis rat model with implantation in the femoral medullary cavity and inoculation with methicillin-resistant Staphylococcus aureus was established and evaluated by radiographical, microbiological, and histopathological assessments. Our in vivo study demonstrated that NT-H coatings exhibited significant anti-infection capability compared with the Ti and NT-C groups. In conclusion, HACC-loaded nanotubes fabricated on a titanium substrate show good compatibility with osteogenic cells and enhanced anti-infection ability in vivo, providing a good foundation for clinical application to combat orthopedic implant-associated infections. | Ying Yang Haiyong Ao Yugang Wang Wentao Lin Shengbing Yang Shuhong Zhang Zhifeng Yu Tingting Tang | 2016 | Bone Research2016，4，3： | 9 |
| 4 | Inhibition of CCL2 by bindarit alleviates diabetes-associated periodontitis by suppressing inflammatory monocyte infiltration and altering macrophage properties显示文摘Diabetes-associated periodontitis(DP)aggravates diabetic complications and increases mortality from diabetes.DP is caused by diabetes-enhanced host immune-inflammatory responses to bacterial insult.In this study,we found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to DP.Moreover,inhibition of CCL2 by oral administration of bindarit reduced alveolar bone loss and increased periodontal epithelial thickness by suppressing periodontal inflammation.Furthermore,bindarit suppressed the infiltration of proinflammatory monocytes and altered the inflammatory properties of macrophages in the diabetic periodontium.This finding provides a basis for the development of an effective therapeutic approach for treating DP. | Zongshan Shen Shuhong Kuang Min Zhang Xin Huang Jiayao Chen Meiliang Guan Wei Qin Hockin H.K.Xu Zhengmei Lin | 2021 | Cellular & Molecular Immunology2021，18，9： | 6 |
| 5 | Exosomes derived from 3D-cultured MSCs improve therapeutic effects in periodontitis and experimental colitis and restore the Th17 cell/Treg balance in inflamed periodontium显示文摘Although mesenchymal stem cell-derived exosomes(MSC-exos)have been shown to have therapeutic effects in experimental periodontitis,their drawbacks,such as low yield and limited efficacy,have hampered their clinical application.These drawbacks can be largely reduced by replacing the traditional 2D culture system with a 3D system.However,the potential function of MSC-exos produced by 3D culture(3D-exos)in periodontitis remains elusive.This study showed that compared with MSC-exos generated via 2D culture(2D-exos),3D-exos showed enhanced anti-inflammatory effects in a ligature-induced model of periodontitis by restoring the reactive T helper 17(Th17)cell/Treg balance in inflamed periodontal tissues.Mechanistically,3D-exos exhibited greater enrichment of miR-1246,which can suppress the expression of Nfat5,a key factor that mediates Th17 cell polarization in a sequence-dependent manner.Furthermore,we found that recovery of the Th17 cell/Treg balance in the inflamed periodontium by the local injection of 3D-exos attenuated experimental colitis.Our study not only showed that by restoring the Th17 cell/Treg balance through the miR-1246/Nfat5 axis,the 3D culture system improved the function of MSC-exos in the treatment of periodontitis,but also it provided a basis for treating inflammatory bowel disease(IBD)by restoring immune responses in the inflamed periodontium. | Yong Zhang Jiayao Chen Haijun Fu Shuhong Kuang Feng He Min Zhang Zongshan Shen Wei Qin Zhengmei Lin Shuheng Huang | 2021 | International Journal of Oral Science2021，13，4： | 4 |
| 6 | Viscous liquid sloshing damping in cylindrical container using a volume of fluid method显示文摘Liquid sloshing is a kind of very complicated free surface flow and exists widely in many fields.In order to calculate liquid sloshing damping precisely a volume of fluid method based on finite volume scheme is used to simulate free surface flows in partly filled cylindrical containers.A numerical method is pre-sented to simulate the movement of the free surface flow,in which a piecewise linear interface con-struction scheme and an unsplit Lagrangian advection scheme instead of Eulerian advection scheme are used.The damping performance of liquid sloshing in cylindrical containers under fundamental sloshing mode is investigated.There are four factors determining the surface-wave damping:free surface,boundary-layer,interior fluid and contact line.In order to study different contributions from these four factors to whole damping,several examples are simulated.No-slip and slip wall boundary conditions on both side wall and bottom wall of the cylindrical containers are studied to compare with the published results obtained by solving Stokes equations.In the present method the first three main factors can be considered.The simulation results show that the boundary-layer damping contribution increases while the interior fluid damping contribution decreases with increase of Reynolds number. | Wei Yang ShuHong Liu Hong Lin | 2009 | Science China(Technological Sciences)2009，52，6： | 3 |
| 7 | Application of a novel redox-active electrolyte in MnO_2-based supercapacitors显示文摘This paper reports a novel strategy for preparing redox-active electrolyte through introducing a redox-mediator(p-phenylenediamine,PPD) into KOH electrolyte for the application of ball-milled MnO 2-based supercapacitors.The morphology and compositions of ball-milled MnO 2 were characterized using scanning electron microscopy(SEM) and X-ray diffraction(XRD).The electrochemical properties of the supercapacitor were evaluated by cyclic voltammetry(CV),galvanostatic charge-discharge(GCD),and electrochemical impedance spectroscopy(EIS) techniques.The introduction of p-phenylenediamine significantly improves the performance of the supercapacitor.The electrode specific capacitance of the supercapacitor is 325.24 F g-1,increased by 6.25 folds compared with that of the unmodified system(44.87 F g-1) at the same current density,and the energy density has nearly a 10-fold increase,reaching 10.12 Wh Kg-1.In addition,the supercapacitor exhibits good cycle-life stability. | YU HaiJun WU JiHuai FAN LeQing LIN YouZhen CHEN ShuHong CHEN Yuan WANG JiangLi HUANG MiaoLiang LIN JianMing LAN Zhang HUANG YunFang | 2012 | Science China Chemistry2012，55，7： | 3 |
| 8 | Limits on theory of mind use in adults显示文摘 | Boaz Keysar Shuhong Lin Dale J Barr | 2003 | Cognition2003，，1： | 1 |
| 9 | Super-hydrophobicsurfaces:From natural to artificial显示文摘 | Feng Lin Li Shuhong Li Yingshu | 2002 | Advanced Matericals2002，14，24： | 1 |
| 10 | 显示文摘 | Feng Lin Li Shuhong Li Yingshun | 2002 | Advanced Materials2002，14，2： | 1 |
| 11 | 显示文摘 | Feng Lin Li Shuhong Li Yingshun | 2002 | Advanced Materials2002，14，24： | 1 |
| 12 | Effects of dietary chitosan oligosaccharides and Bacillus coagulans on the growth, innate immunity and resistance of koi ( Cyprinus carpio koi )显示文摘 | Shimei Lin Shuhong Mao Yong Guan Lin Luo Li Luo Yu Pan | 2012 | Aquaculture2012，，： | 1 |
| 13 | Reliability and covariance estimation of weighted k -out-of- n multi-state systems显示文摘 | Yong Wang Lin Li Shuhong Huang Qing Chang | 2012 | European Journal of Operational Research2012，，1： | 1 |
| 14 | Super-hydro- phobic Surface of Aligned Polyacrylonitrile Nanofibers 显示文摘 | Lin Feng Shuhong Li Huanjun Li | 2002 | Angew Chem2002，114，7： | 1 |
| 15 | Super-Hydrophobic Surface:From Natural to Artificial显示文摘 | Feng Lin Li Shuhong Li Yingshun | 2002 | Advanced Materials2002，14，： | 1 |
| 16 | Super-hydrophobic Surface of Aligned Polyacrylonitrile Nanofibers 显示文摘 | Lin Feng Shuhong Li Huanjun Li | 2002 | Angew Chem Int Ed2002，41，7： | 1 |
| 17 | Photocatalytic property of nitrogen-doped layered perovskite K2La2Ti3O10显示文摘 | Yunfang Huang Yuelin Wei Shuhong Cheng Leqing Fan Yibin Li Jianmin Lin Jihuai Wu | 2010 | Solar Energy Materials & Solar Cells2010，94，： | 1 |
| 18 | Super - hydrophobic surface: from natural to artificial 显示文摘 | FENG LIN LI SHUHONG LI YINGSHUN | 2002 | Adv Mater2002，，14： | 1 |
| 19 | Super-hydrophobic surfaces: From natural to artificial 显示文摘 | Feng Lin Li Shuhong Li Yingshun | 2002 | Advanced Materials2002，14，24： | 1 |
| 20 | Fermentation process enhanced production and bioactivities of oolong tea polysaccharides显示文摘 | Yuefei Wang Shuhong Shao Ping Xu Hao Chen Shoei-Yn Lin-Shiau Yea-Tzy Deng Jen-Kun Lin | 2011 | Food Research International2011，，1： | 1 |
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