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| 1 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 2 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 3 | Pemetrexed: A multitargeted antifolate显示文摘 | Kristan D. Rollins Celeste Lindley | 2005 | Clinical Therapeutics2005，，9： | 2 |
| 4 | The Effects of Screw Length on Stability of Simulated Osteoporotic Distal Radius Fractures Fixed With Volar Locking Plates显示文摘 | Lindley B. Wall Michael D. Brodt Matthew J. Silva Martin I. Boyer Ryan P. Calfee | 2012 | Journal of Hand Surgery2012，，3： | 2 |
| 5 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 6 | Internal rupture of bonded rubber cylinders in tension 显示文摘 | Gent A N Lindley P B | 1959 | Proc R Soc London P R Society1959，249，1257： | 2 |
| 7 | Natural Rubber Structural Bearings显示文摘 | Lindley P B | 1981 | Joint Sealing and Bearing Systems for Concrete Structure1981，1，2： | 1 |
| 8 | Genotypes of Pneumocystis jiroveci isolates obtained in Harare,Zimbabwe,and London,United Kingdom显示文摘 | Lindley AR Ambrose HE | 2003 | Antimicrob Agents Chemother2003，47，12： | 1 |
| 9 | Streptozotocin-induced type 1 diabetes mel itus alters the morphology,secretory function and acyl lipid contents in the isolated rat parotid salivary gland显示文摘 | Mahay S Adeghate E Lindley MZ | | 0，，1： | 1 |
| 10 | Contact damage of poly (methylmethacrylate) during complex micro-displacements显示文摘 | Briscoe B J Chateauminois A Lindley T C | | 0，，1： | 1 |
| 11 | Characterisation and transplantation of enteric nervous system progenitor cells 显示文摘 | Almond S Lindley RM Kenny SE | 2007 | Gut2007，56，： | 1 |
| 12 | Dynamic Programming and Decision Theory 显示文摘 | D V Lindley | 1961 | Applied Statistics1961，10，1： | 1 |
| 13 | Early Cainozoic stratigraphy and structure of the Ga- zelle Peninsular, east New Britain:An example of eitxtension tee- tonics in the New Britain arc-trench complex 显示文摘 | Lindley D | 1988 | Australian Journal of Earth Science1988，35，2： | 1 |
| 14 | Thermal Performance of Three Solar Air Heaters 显示文摘 | Parker B F Lindley M R Colliver D G Murphy W E | 1993 | Solar Energy1993，51，6： | 1 |
| 15 | Multiple genes in the left half of the cag pathogenicity island of Hlicobacter pylori are required for tyrosine Kinase-dependent transcription of interleukin-8 in gastric epithelial cells 显示文摘 | Li SD Kersulyte D Lindley IJ | 1999 | Infect Immun1999，67，8： | 1 |
| 16 | Com- plications of axial lumbar interbody fusion 显示文摘 | LINDLEY E M MCCULLOUGH M A BURGER E L | 2011 | J Neurosurg- Spine2011，3，3： | 1 |
| 17 | pronding hospice care to children and young aducts: A deslriptire study of end-of-life organisations显示文摘 | Lisa Lindley Barbara Mark Shoou-Yih Daniel Lee | 2009 | J Hosp Palliat Nurs2009，11，6： | 1 |
| 18 | Production of monoclonal antibodies using recombinant baculovirus displaying gp64-fusion proteins 显示文摘 | Lindley K M Su J L Hodges P K | 2000 | J Immunol Methods2000，234，12： | 1 |
| 19 | Bayes estimaters for the linear model显示文摘 | Lindley D V Smith A F M | 1972 | Journal of the Royal Statistical Society Series B1972，34，： | 1 |
| 20 | The functionally and physiologically plastic adult auditory system显示文摘 | Nelson CT Lindley GAT | 1998 | J Acoust Soc Am1998，103，： | 1 |
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