维普中文期刊产品整合服务
2篇 您的检索式:作者名="LINGuiting"
    题名 作者 年代 出处 被引量
1Functional interaction of TCF4 with ATF5 to regulate the Wnt signaling pathway显示文摘Wnt signaling directs cell-fate choices during embryonic development and tissue tumorigenesis. T cell fac-tor 4 (TCF4) plays a pivotal role in the Wnt signaling path-way. We demonstrate that a specific protein-protein interac-tion occurs between TCF4 and ATF5 (activating transcrip-tion factor 5) —— a new member of cAMP response element binding protein (CREB) with the yeast two-hybrid system. The N-terminal and DNA binding domain of TCF4 (TCF4ND, 1—495 aa) and the C-terminal spanning bZIP domain of ATF5 (162—282 aa) were found to be responsible for the interaction, and the C-terminal of ATF5 (ATF5/C) showed a much stronger interaction with TCF4ND than the full-length of ATF5 by detecting the b-gal activity. Further-more, overexpression of ATF5/C enhanced transcriptional activation by TCF4 proteins in luciferase assay by transient transfection. Taken together, these data suggest that ATF5 may function as a co-activator to potentiate the ability of TCF4 to activate transcription.YEXiongjun ZHANGZhiwen ZHANGXinjun LINGuiting XIONGShiqin JINGuihua HANLiang HUANGShisi CHENPeila AIJunkui XINDianqi GUOYinglu CHANGZhijie 2003Chinese Science Bulletin2003,48,7:1
2Malignant neurinoma of the stomach显示文摘Pasquazzi M Linguit I 1966Poli-clinico Prat1966,73,7:1
返回顶部 每页显示:
共1页 首页 上一页 第1页 下一页 末页 /1 跳转

网站首页 | 关于我们 | 联系我们 | 产品服务 | 客服中心 | 广告服务 | 版权声明 | 网站联盟 | 友情链接 | 售卡网点

版权所有© 渝B2-20050021-1 渝公网安备 50019002500403号 违法和不良信息举报中心

互联网出版许可证 新出网证(渝)字10号 全国400电话 - 免长途话费