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| 1 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 2 | QTc in- terval lengthening is related to CYP2D6 hydroxyl-ation capacity and plasma concentration of thio- ridazine in patients显示文摘 | Llerena A Berecz R de la Rubia A | 2002 | J Psyehopharmacol2002，16，4： | 1 |
| 3 | QTc inter- val, CYP2D6 and CYP2C9 genotypes and risperi- done plasma concentrations 显示文摘 | Llerena A Berecz R Dorado P | 2004 | J Psychopharma- col2004，18，2： | 1 |
| 4 | Effect of thioridazine dosage on the debrisoquine hydroxyl- ation phenotype in psychiatric patients with differ- ent CYP2D6 genotypes 显示文摘 | Llerena A Berecz R de la Rubia A | 2001 | Ther Drug Monit2001，23，6： | 1 |
| 5 | CYP2D6 polymorphism: implications for antipsychotie drug response, schizophrenia and personality traits显示文摘 | Dorado P Penas-Lledo EM Llerena A | 2007 | Pharmacogenomics2007，8，11： | 1 |
| 6 | Organisational rules, codification and knowledge creation in inter -organisation cooperative agreements 显示文摘 | AVADIKYAN A LLERENA P MIREILLE ROZAN ANNE | 2001 | Research Policy2001，30，： | 1 |
| 7 | Erosion processes in high mountain agricultural terraces in peru显示文摘 | Moshe Inbar Carlos A Llerena | 2000 | Mountain Research and Development2000，20，1： | 1 |
| 8 | Relationship between personality and debrisoquine hydroxylation capaeity: suggestion of an endogenous neuroactive substrate or product of the cytochrome P4502D6显示文摘 | Llerena A Edman G Cobaleda J | 1993 | Acta Psychiatr Scand1993，87，： | 1 |
| 9 | High-performance liquid chromatography method using ultraviolet detection for the quantification of aripiprazole and dehydroaripiprazole in psychiatric patients显示文摘 | Pedro Dorado Fernando de Andrés María Eugenia G. Naranjo Eva M. Pe?as-Lledó Idilio González Antonio P. González Alfredo de la Rubia Adrián LLerena | 2012 | Drug Metabolism and Drug Interactions2012，，3： | 1 |
| 10 | Relationship between risperidone and 9-hydroxy-risperidone plasma concentrations and CYP2D6 enzyme activity in psychiatric patients显示文摘 | Berecz R LLerena A de la Rubia A | 2002 | Pharmacopsychiatry2002，35，： | 1 |
| 11 | Strategic alliances in higher education in Ecuador: the challenge of knowledge transfer and its effect on the learning curve 显示文摘 | Marlena Leon Mendozaa Juan Pablo Ortega Santosb Christian A Llerena Gavilanezc | 2014 | Suma De Negocios2014，5，12： | 1 |
| 12 | CYP450 genotype and pharmacogenetic association studies: a critical appraisal 显示文摘 | Shah RR Gaedigk A LLerena A | 2016 | Pharmacogenomics2016，17，3： | 1 |
| 13 | Schizophrenia stigma among medical and nursing undergraduates显示文摘 | Llerena A Cáceres MC Pe(n)as-LLed6 EM | | 0，，05： | 1 |
| 14 | Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography:application to the evaluation of CYP2D6 drug interactions显示文摘 | LLerena A Berecz R Dorado P el al | 2003 | J Chromatogr B Analyt Technol Biomed Life Sci2003，783，1： | 1 |
| 15 | A game theoretical approach of price negotiation and coordination in an innovative firmsupplier context: an experimental analysis显示文摘 | Duvaliet J Garapin A Llerena D | 2004 | International Negotiation2004，9，： | 1 |
| 16 | Binge drinking: Burden of liver disease and beyond显示文摘The consumption of alcoholic beverages is harmful to human health. In recent years, consumption patterns of alcoholic beverages have changed in our society, and binge drinking has generalized. It is considered to be a socio-sanitary problem with few known consequences in terms of individual and third-party social impacts(in the form of violence or traffic accidents) and its organic impact(affects the liver and other organs and systems, such as the nervous and cardiovascular systems) and represents an important financial burden due to its increasing economic impact. This review provides a global approach to binge drinking and emphasizes its epidemiological character, the effect of this type of consumption and the possible management of a problem with an increasing tendency in our society. | Susana Llerena María Teresa Arias-Loste Angela Puente Joaquín Cabezas Javier Crespo Emilio Fábrega | 2015 | World Journal of Hepatology2015，7，27： | 1 |
| 17 | Determination of risperidone and 9-hydroxyrisperidone in human plasma by liquid chromatography:application to the evaluation of CYP2D6 drug interactions显示文摘 | LLerena A Berecz R Dorado P | 2003 | J Chromatogr B2003，783，： | 1 |
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