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| 1 | Aminoglycoside-induced and non-syndromic hearing loss is associated with the G7444A mutation in the mitochondrial COI/tRNA (Ser(UCN)) genes in two Chinese families显示文摘 | Zhu Y Qian YP Tang XW Wang JD Yang L Liao ZS Li RH Ji JZ Li ZY Chen JF Choo DI Lu JX Guan MX | 2006 | 中国生物学文摘2006，20，4： | 16 |
| 2 | Tumor size as a prognostic factor in patients with advanced gastric cancer in the lower third of the stomach显示文摘AIM: To explore the impact of tumor size on outcomes in patients with advanced gastric cancer in the lower third of the stomach. METHODS: We retrospectively analyzed the clinical records of 430 patients with advanced gastric cancer in the lower third of the stomach who underwent distal subtotal gastrectomy and D2 lymphadenectomy in our hospital from January 1998 to June 2004. Receiver-operating characteristic (ROC) curve analysis was used to determine the appropriate cutoff value for tumor size, which was measured as maximum tumor diameter. Based on this cutoff value, patients were divided into two groups: those with large-sized tumors (LSTs) and those with small-sized tumors (SSTs). The correlations between other clinicopathologic factors and tumor size were investigated, and the 5-year overall survival (OS) rate was compared between the two groups. Potential prognostic factors were evaluated by univariate KaplanMeier survival analysis and multivariate Cox's propor-tional hazard model analysis. The 5-year OS rates in the two groups were compared according to pT stage and pN stage. RESULTS: The 5-year OS rate in the 430 patients with advanced gastric cancer in the lower third of the stomach was 53.7%. The mean ± SD tumor size was 4.9 ± 1.9 cm, and the median tumor size was 5.0 cm. ROC analysis indicated that the sensitivity and specificity results for the appropriate tumor size cutoff value of 4.8 cm were 80.0% and 68.2%, respectively (AUC=0.795, 95%CI: 0.751-0.839, P=0.000). Using this cutoff value, 222 patients (51.6%) had LSTs (tumor size ≥ 4.8 cm) and 208 (48.4%) had SSTs (tumor size<4.8 cm). Tumor size was significantly correlated with histological type (P=0.039), Borrmann type (P=0.000), depth of tumor invasion (P=0.000), lymph node metastasis (P=0.000), tumor-nodes metastasis stage (P=0.000), mean number of metastatic lymph nodes (P=0.000) and metastatic lymph node ratio (P=0.000). Patients with LSTs had a significantly lower 5-year OS rate than those with SSTs (37.1% vs 63.3%, P=0.000). Univariate analysis showed that depth of tumor invasion (c 2=69.581, P=0.000), lymph node metastasis (c 2=138.815, P=0.000), tumor size (c 2=78.184, P=0.000) and metastatic lymph node ratio (c 2=139.034, P=0.000) were significantly associated with 5-year OS rate. Multivariate analysis revealed that depth of tumor invasion (P=0.000), lymph node metastasis (P=0.019) and tumor size (P=0.000) were independent prognostic factors. Gastric cancers were divided into 12 subgroups: pT2N0; pT2N1; pT2N2; pT2N3; pT3N0; pT3N1; pT3N2; pT3N3; pT4aN0; pT4aN1; pT4aN2; and pT4aN3. In patients with pT2-3N3 stage tumors and patients with pT4a stage tumors, 5-year OS rates were significantly lower for LSTs than for SSTs (P<0.05 each), but there were no significant differences in the 5-year OS rates in LST and SST patients with pT23N0-2 stage tumors (P > 0.05). CONCLUSION: Using a tumor size cutoff value of 4.8cm, tumor size is a prognostic factor in patients with pN3 stage or pT4a stage advanced gastric cancer located in the lower third of the stomach. | Hong-Mei Wang, Chang-Ming Huang, Chao-Hui Zheng, Ping Li, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Jun Lu, Department of Gastric Surgery, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China Author contributions: Wang HM and Huang CM conceived of the study, analyzed the data, and drafted the manuscript Zheng CH, Li P and Xie JW helped revise the manuscript critically for important intellectual content Wang JB, Lin JX and Lu J helped collect data and design the study and all authors read and approved the final manuscript. | 2012 | World Journal of Gastroenterology2012，18，38： | 15 |
| 3 | Preliminary study on light hydrocarbons in ore-forming fluids of gold and antimony deposits in southwestern Guizhou, China显示文摘METAL minerals precipitate generally from ore-forming fluid. It is suggested that organic mat-ter in ore-forming fluid is one of the best media which show the role of organic matter in oregenesis. Because mineralizing temperatures of many ore deposits exceeded the stable rangesof liquid hydrocarbons, only light hydrocarbons were preserved well in inclusions. Thus, | Zhuang, HP Lu, JL Fu, JM Liu, JZ Shi, JX | 1997 | Chinese Science Bulletin1997，42，20： | 8 |
| 4 | Endovascular management of pararenal aortic aneurysms with multiple overlapping uncovered stents显示文摘 | Zhang YX Lu QS Feng JX | 2013 | J Vasc Surg2013，58，61： | 1 |
| 5 | Effect of aloe polysaccharide on caspase-3expression following cerebral ischemia and reperfusion injury in rats显示文摘 | Lu ZQ Deng YJ Lu JX | 2012 | Mol Med Report2012，6，2： | 1 |
| 6 | Predictions of abdominal visceral obesity from body mass index,waist cirurnference and waist-hip ratio in Chinese adults receiver operating characteristic curres analysis显示文摘 | Jai WP Lu JX Xiang KS | | 0，，3： | 1 |
| 7 | Activated human hydroxy‐carboxylic acid receptor‐3 signals to MAP kinase cascades via the PLC‐dependent PKC and MMP‐mediated EGFR pathways显示文摘 | Q Zhou G Li XY Deng XB He LJ Chen C Wu Y Shi KP Wu LJ Mei JX Lu NM Zhou | 2012 | British Journal of Pharmacology2012，，6： | 1 |
| 8 | Role of intercounections in porous bioceramics on bone recolonization in vitro and in vivo显示文摘 | Lu JX Flautre B Anselme K | 1999 | J Mater Sci Mater Med1999，10，2： | 1 |
| 9 | In- creased dimensional stability of Chi-nese fir through steam-heat treatment 显示文摘 | CAO Y J LU JX HUANG RF | 2012 | European Journal of Wood and Wood Products2012，70，4： | 1 |
| 10 | Correlation between inter- leukin-18 promoter-607C/A polymorphism and suscepti- bility to ischemicstroke显示文摘 | Lu JX Lu ZQ Zhang SL | 2013 | Braz J Med Biol Res2013，46，6： | 1 |
| 11 | Effects of recombinant staphylokinase on coronary thrombosis in Chineseexperimental miniature swine显示文摘 | LU JX Shang XH FuJH | 2002 | Acta Pharmacol Sin2002，23，： | 1 |
| 12 | Optimal waist circumference cutoffs for abdominal obesity in Chinese显示文摘 | Bao YQ Lu JX Wang C | 2008 | Atherosclerosis2008，201，2： | 1 |
| 13 | Selenite induction of DNA strand breaks and apoptosis in mouse leukemic L1210 cells显示文摘 | Lu JX Kaeck M Jiang C | 1994 | Biochem Pharmacol1994，47，： | 1 |
| 14 | Nebulized Ceftazidime and Amikacin in Ventilator-associated Pneumonia Causedby Pseudomonas aeruginosa显示文摘 | Lu Q Yang JX Liu ZH | 2011 | Am J Respir Crit Care Med2011，108，： | 1 |
| 15 | Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/β-eatenin pathway 显示文摘 | Lu D Liu JX Endo T | 2009 | PLoS One2009，4，12： | 1 |
| 16 | Correlation between interleukin-18 promoter-607C/A polymorphism and susceptibility to ischemic stroke显示文摘 | Lu JX Lu ZQ Zhang SL | 2013 | Braz J Med Biol Res2013，46，6： | 1 |
| 17 | Comparmive study of tissue reactions to calcium phosphate ceramics among cancellous,cortical, and medullar bone sites in rabbits 显示文摘 | Lu JX Gallur A Flamre B | 1998 | J Biomed Miner Res1998，42，： | 1 |
| 18 | The application of CBL teaching model in clinical teaching of neurosurgery显示文摘 | CHEN JX LU YC CHEN C | 2010 | Northwest Medical Education2010，18，1： | 1 |
| 19 | Effect of chitosan on rat knee cartilage显示文摘 | Lu JX Prudhommeaux F Meunier A | | 0，，20： | 1 |
| 20 | Effects of chitosan on rat knee cartilages显示文摘 | Prudhommeaux F Meunier A | 1999 | Biomaterials1999，20，20： | 1 |
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