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| 1 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 2 | 相关性和一致性:这对相仿概念和测量方法的回顾与阐明(英文)显示文摘一致性(agreement)和相关性(correlation)是两个广泛使用的概念,用来评估变量之间的关联。虽然二者相似且相关,但是它们代表关联完全不同的概念。评估变量之间的一致性假设变量测量的是相同的结构,而在变量测量完全不同的结构时也可以评估它们之间的相关性。这种概念上的差异就要求使用不同的统计方法,并且当评估一致性或相关性时,统计方法根据数据的分布和研究者的兴趣可能会有所不同。例如,Pearson相关性,作为评估连续变量之间相关性的一种普遍测量方法,只有用于符合线性关系的变量时才能提供有用的信息;当用于不符合线性关系的变量时就无法提供准确信息甚至会产生误导。同样地,内部相关性,作为一种评估连续变量之间一致性的常用方法,如果一致性不好的实质正好是研究兴趣所在,那么该测量就不能为研究者提供充分的信息。本报告回顾了一致性和相关性的概念,并讨论了几种常用方法在应用中的差异。 | Liu JY Tang W Chen GQ Lu Y Feng CY Tu XM | 2016 | 上海精神医学2016，28，2： | 6 |
| 3 | Visual function and morphological changes in the macular area of patients with type 2 diabetes mellitus after intensive insulin therapy显示文摘 | ChenZG Zhang JY Lu CJ Lin SS ChertJW Zhong HL Tian B Wei WB | 2014 | Chinese Medical Journal2014，，4： | 3 |
| 4 | Effects of Zr on Microstructure and Short-TermStrength in GH586显示文摘0.020, 0.045 and 0.075 wt pct Zr were added to a Ni-base superalloy GH586 to investigate theirefFects on the microstructure and the short-term strengths at 850℃. The results showed thatproper Zr addition could improve the alloy tensile strength at 850℃ and short-term rupture life at850℃, 580 MPa. Zr exists in both γ’ phase and γ matrix, which caused Zr to distribute in graininstead of segregating in grain boundaries, therefore increased both of their lattice parametersbut decreased the mismatch between them. Meanwhile, it also increased the amount of grain-boundary carbides and decreased their size markedly. These contributed to the improvement ofshort-term rupture life. However, further addition of Zr resulted in forming Zr4C2S2, a plate-fike stable sulphurocarbides in grain boundaries, which decreased short-term strength at hightemperature, and led to a worse hot workability. According to the experimental results, theoptimum content of Zr should be 0.020 wt pct. | Xie, SS Wang, TL Lu, JY Yang, HC Zhao, GP | 1999 | Journal of Materials Science & Technology1999，15，5： | 3 |
| 5 | Rhamnolipid production with indigenous Pseudomonas aeruginosa EM1 isolated from oil-contaminated site 显示文摘 | Wu JY Yeh KL Lu WB | 2008 | Bioresource Technology2008，99，： | 1 |
| 6 | Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflamma-tory cytokine mRNAs显示文摘 | Lu JY Sadri N Schneider RJ | 2006 | Genes Dev2006，20，22： | 1 |
| 7 | Formaldehyde strees 显示文摘 | He RQ Lu J Miao JY | 2010 | Sci China Life Sci2010，，12： | 1 |
| 8 | White matter hyperintensities in post-stroke depression:a case control study显示文摘 | Tang WK Chen YK Lu JY | 2010 | J Neurol Neurosurg Psychiatry2010，81，12： | 1 |
| 9 | Cerebral microbleeds and depression in lacunar stroke 显示文摘 | Tang WK Chen YK Lu JY | 2011 | Stroke2011，42，9： | 1 |
| 10 | Regulation of RANTES promoter activation in gastric epit helial cells infected with Helicobacterpylori显示文摘 | Kudo T Lu H Wu JY | 2005 | Infect Immun2005，73，11： | 1 |
| 11 | Assay of disulfide oxidase and isomerase based on the model of hirudin folding 显示文摘 | Lu BY Chang JY | 2005 | Anal Biochem2005，339，1： | 1 |
| 12 | Apoptosis of psoriatic keratinocytesand the severity of patients'condition显示文摘 | Chen J Lu JY Tang ZH | 2006 | Zhong Nan Da Xue XueBao Yi Xue Ban2006，31，6： | 1 |
| 13 | Is insomnia associated with suieidality in stroke显示文摘 | Tang WK Lu JY Liang H | 2011 | Arch Phys Med Rehabil2011，92，12： | 1 |
| 14 | Impairment of cardiac insulin signaling and myocardial contractile performance in highcholesterol/fructose-fed rats显示文摘 | DENG JY HUANG JP LU LS et ol | 2007 | Am J Physiol Heart Circ Physiol2007，293，2： | 1 |
| 15 | High-level expression of ampC beta-lactamase due to insertion of nucleotides between -10 and -35 promoter sequences in Escherichia coli clinical isolates: cases not responsive to extended-spectrum-cephalosporin treatment 显示文摘 | Siu LK Lu PL Chen JY | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 16 | Is fatigue associated with short - Term health- related quality of life in stroke显示文摘 | Tang WK Chen YK Lu JY | 2010 | Arch Phys Med Rehab2010，91，10： | 1 |
| 17 | Pericardial fluid and serum levels of vascular endothelial growth factor and endestatin in patients with or without coronary artery disease显示文摘 | Liou JY Shyu KG Lu MJ | 2006 | J Formos Med Assoc2006，105，5： | 1 |
| 18 | A bronchofiberoscopy-asso- ciated outbreak of multidrug-resistant Acinetobacter bau- mannii in an intensive care unit in Beijing,China显示文摘 | Xia YK Lu CL Zhao JY | 2012 | BMC Infectious Diseases2012，12，： | 1 |
| 19 | New metric for object-oriented design显示文摘 | Chen JY Lu JF | 1993 | Information and Software Technology1993，35，4： | 1 |
| 20 | Effects of treatment of AML- M3(APL) and their remission maintenance with realgar: a pilot clinical and laboratory atudy on 38 latients 显示文摘 | Lu DP Qiu JY Chen SS | 1997 | Blood1997，90，： | 1 |
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