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| 1 | Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by overexpression of Fas显示文摘AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastric cancer cellSGC7901/VCR(resistant to Vincristine).METHODS The cell cycle alteration wasobserved by FACS.The sensitivity of gastriccancer cells to apoptosis was determined by invitro apoptosis assay.The drug sensitization ofcells to several anti-tumor drugs was observedby MTT assay.Immunochemical method wasused to show expression of P-gp and Topo Ⅱ ingastric cancer cells.RESULTS Comparing to SGC7901 and pBK-SGC7901/VCR,fas-SGC7901/VCR showeddecreasing G2 cells and increasing S cells,theG2 phase fraction of pBK-SGC7901/VCR wasabout 3.0 times that of fas-SGC7901/VCR,but Sphase fraction of fas-SGC7901/VCR was about1.9 times that of pBK-SGC7901/VCR,indicatingS phase arrest of fas-SGC7901/VCR.FACS alsosuggested apoptosis of fas-SGC7901/VCR,fas-SGC7901/VCR was more sensitive to apoptosisinducing agent VM-26 than pBK-SGC7901/VCR.MTT assay showed increased sensitization offas-SGC7901/VCR to DDP,MMC and 5-FU,butsame sensitization to VCR according to pBK-SGC7901/VCR.SGC7901,pBK-SGC7901/ VCRand fas-SGC7901/VCR had positively stainedTopo Ⅱ equally.P-gp staining in pBK- SGC7901/VCR was stronger than in SG07901,but there was little staining of P-gp in fas.SGC7901/VCR.CONCLUSION fas gene transduction couldreverse the MDR of human drug-resistant gastriccancer cell SGC7901/VCR to a degree,possiblybecause of higher sensitization to apoptosis anddecreased expression of P-gp. | Yin F Shi YQ Zhao WP Xiao B Miao JY Fan DM | 2000 | World Journal of Gastroenterology2000，6，5： | 24 |
| 2 | High-dose methylprednisolone can induce remissions in patients with fludarabine- refractory chronic lymphocytic leukaemia显示文摘 | Xu, W Miao, KR Hong, M Zhu, DX Fang, C Dong, HJ Wang, DM Cao, X Li, JY | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 5 |
| 3 | Formaldehyde strees 显示文摘 | He RQ Lu J Miao JY | 2010 | Sci China Life Sci2010，，12： | 1 |
| 4 | Suppression of apoptosis by inhibition of phosphatidylcholine-specific phospholipase Cin vascular endothelial cells显示文摘 | Miao JY Kaji K Hayashi H Araki S | 1997 | Endothelium1997，5，： | 1 |
| 5 | High-definition CT gemstone spectral imaging of the brain:initial result of selecting optimal monochromatic image for beam-hardening artifacts and image noise reduction显示文摘 | Lin XZ Miao F li JY | 2011 | J Comput Assist Tomogr2011，35，2： | 1 |
| 6 | Gemstone spectral imaging of the brain: initial results of selecting optimal monochromatic image for beam-hardening artifacts and image noise reduction 显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，： | 1 |
| 7 | High-definition CT gemstone spec- tral imaging of the brain :initial results of selecting optimal mono- chromatic image for beam-hardening artifacts and Image noise re- duction 显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，5： | 1 |
| 8 | Suppression of apoptosis by inhibition of phosphatidylcholine-specific phospholipase C in vascular endothelial cells显示文摘 | Miao JY Kaji K Hayashi H Araki S | 1997 | Endothelium1997，5，： | 1 |
| 9 | Clinical experience with molechlaradsorbent recirculating system in patienfs with drug-indued Senilecataract显示文摘 | Zhou XM Miao JY Yang Y | 2010 | Nursing2010，13，20： | 1 |
| 10 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 11 | Role of salicylic acid in tomato defense against cotton bollworm,Helicoverpa armigera Hubner显示文摘 | Peng JY Deng XJ Huang JH Jia SH Miao XX Huang YP | 2004 | Zeitschrift Für Naturforschung2004，，11： | 1 |
| 12 | Safety climate measurement at workplace in China: A validity and reliability assessment 显示文摘 | LIN SH TANG WJ MIAO JY | 2008 | Saf Sci2008，46，7： | 1 |
| 13 | Draft genome of the kiwifruit Actinidia chinensis 显示文摘 | Huang SX Ding J Deng DJ Tang W Sun HH Liu DY Zhang L Niu XL Zhang X Meng M Yu JD Liu J Han Y Shi W Zhang DF Cao SQ Wei ZJ Cui YL Xia YH Zeng HP Bao K Lin L Min Y Zhang H Miao M Tang XF Zhu YZ Sui Y Li GW Sun HJ Yue JY Sun JQ Liu FF Zhou LQ Lei L Zheng XQ Liu M Huang L Song J Xu CH Li JW Ye KY Zhong SL Lu BR He GH Xiao FM Wang HL Zheng HK Fei ZJ Liu YS | 2013 | Nat Commun2013，4，： | 1 |
| 14 | High-definition CT Gemstone spec-tral imaging of the brain:initial results of selecting optimal mono-chromatic image for beam-hardening artifacts and image noise re-duction显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，2： | 1 |
| 15 | High-definition CT Gemstone spectral imaging of the brain : initial results of selecting optimal monochro- matic image for beam-hardening artifacts and image noise reduc- tion显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，2： | 1 |
| 16 | High - definition CT Gemstone spectral ima- ging of the brain: initial results of selecting optimal mono - chromatic image for beam - hardening artifacts and image noise reduction 显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，2： | 1 |
| 17 | High-definition CT gemstone spectralimaging of the brain:initial results of selecting optimal monochromatic image for beam-harding artifacts and image noise reduction显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，： | 1 |
| 18 | High-definition CT gemstone results of selecting optimal mono-chromatic image noise reduction显示文摘 | Lin XZ Miao F Li JY | 2011 | Journal of Computer Assisted spectral imaging of the brain: Initial for beam-hardening artifacts and image Tomography2011，35，2： | 1 |
| 19 | High-definition CT Gemstone spectral imaging of the brain:initial results of selecting optimal monochromatic image for beam-hardening artifacts and image noise reduction显示文摘 | Lin XZ Miao F Li JY | 2011 | J Comput Assist Tomogr2011，35，2： | 1 |
| 20 | The negative prognostic significance of positive direct antiglobulin test in Chinese patients with chronic lymphocytic leukemia显示文摘 | Xu W Li JY Miao KR | | 0，，09： | 1 |
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