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| 1 | Toll-like receptor 9 polymorphisms and Helicobacter pylori influence gene expression and risk of gastric carcinogenesis in the Brazilian population显示文摘BACKGROUND Toll-like receptors(TLRs)are the first line of host defense,and are involved in Helicobacter pylori(H.pylori)recognition and activation of both inflammatory and carcinogenic processes.The presence of single nucleotide polymorphisms(SNPs)in genes that activate the immune response may modulate the risk of precancerous lesions and gastric cancer(GC).Among them,Toll-like receptor 9(TLR9)polymorphisms have emerged with a risk factor of infectious diseases and cancer,however the studies are still inconclusive.AIM To evaluate whether TLR9 rs5743836 and rs187084 SNPs contribute to the risk of gastric carcinogenesis,and its influence on mRNA expression.METHODS A case-control study was conducted to evaluate two TLR9 SNPs(TLR9-1237 TCrs5743836 and TLR9-1486 CT-rs187084)in chronic gastritis(CG)and GC patients.A total of 609 DNA samples of peripheral blood[248 CG,161 GC,and 200 samples from healthy individuals(C)]were genotyped by polymerase chain reaction-restriction fragment length polymorphism.All samples were tested for the H.pylori infection using Hpx1 and Hpx2 primers.Quantitative polymerase chain reaction by TaqMan?assay was used to quantify TLR9 mRNA from fresh gastric tissues(48 GC,26 CG,and 14 C).RESULTS For TLR9-1237,the TC+CC or CC genotypes were associated with a higher risk of GC than C[recessive model odds ratio(OR)=5.01,95%confidence interval(CI):2.52-9.94,P<0.0001],and the CG(recessive model OR=4.63;95%CI:2.44-8.79,P<0.0001)groups.For TLR9-1486,an association between the CT+TT genotypes and increased risk of both GC(dominant model OR=2.72,95%CI:1.57-4.72,P<0.0001)and CG(dominant model OR=1.79,95%CI:1.15-2.79,P=0.0094)was observed when compared to the C group.Moreover,the presence of TLR9-1237 TC/CC+TLR9-1486 CC genotypes potentiate the risk for this neoplasm(OR=18.57;95%CI:5.06-68.15,P<0.0001).The TLR9 mRNA level was significantly higher in the GC group(RQ=9.24,P<0.0001)in relation to the CG group(RQ=1.55,P=0.0010)and normal mucosa(RQ=1.0).When the samples were grouped according to the polymorphic genotypes and the presence of H.pylori infection,an influence of TLR9-1237 TC+CC polymorphic genotypes(P=0.0083)and H.pylori infection(P<0.0001)was observed on the upregulation of mRNA expression.CONCLUSION Our findings show that TLR9 rs5743836 and rs187084 polymorphisms are associated with a higher risk of carcinogenesis gastric,and that TLR9 mRNA levels can be modulated by TLR9-1237 TC+CC variant genotypes and H.pylori infection. | Manoela Dias Susi de Matos Lourenco Caroline Lucas Trevizani Rasmussen Spencer Luis Marques Payao Ana Flavia Teixeira Rossi Ana Elizabete Silva Juliana Garcia de Oliveira-Cucolo | 2019 | World Journal of Gastrointestinal Oncology2019，11，11： | 9 |
| 2 | Effect of heat-moisture treatment on rice starch of varying amylose content显示文摘 | Elessandra da Rosa Zavareze Cátia Regina Storck Luis Antonio Suita de Castro Manoel Artigas Schirmer Alvaro Renato Guerra Dias | 2009 | Food Chemistry2009，，2： | 1 |
| 3 | Valued outranking relations in ELEC- TRE providing manageable disaggregation procedures 显示文摘 | Vincent Mousseau Luis Dias | 2004 | European Journal of Operational Research2004，，156： | 1 |
| 4 | Deeply infiltrating endometriosis affecting the rectum and lymph nodes显示文摘 | Mauricio S. Abrao Sergio Podgaec Joao Antonio Dias Marcelo Averbach Ray Garry Luis Fernando Ferraz Silva Filomena M. Carvalho | 2006 | Fertility and Sterility2006，，3： | 1 |
| 5 | Valued outran- king relations in ELECTRE providing manageable disag- gregation procedures 显示文摘 | VINCENT MOUSSEAU LUIS DIAS | 2004 | European Journal of Operation- al Research2004，152，6： | 1 |
| 6 | Physicochemical, microbiological and antimicrobial properties of commercial honeys from Portugal显示文摘 | Susana Gomes Luis G. Dias Leandro L. Moreira Paula Rodrigues Leticia Estevinho | 2009 | Food and Chemical Toxicology2009，，2： | 1 |
| 7 | Nonlinear analysis in a Lorenz -like system 显示文摘 | Fabio Scalco Dias Luis Fernando Mello Jian-Gang Zhang | 2010 | Nonlinear Analysis: Real World Applications2010，，11： | 1 |
| 8 | FCANN: Anewapproach for extraction and representation of knowledge fromANN trained via Formal Concept Analysis 显示文摘 | Luis E Zárate S Mariano Dias MAJunho Song | 2008 | Neurocomputing2008，71，1315： | 1 |
| 9 | African-American Women Have a Higher Risk for Developing Peripartum Cardiomyopathy显示文摘 | Mindy B. Gentry James K. Dias Antonio Luis Rakesh Patel John Thornton Guy L. Reed | 2010 | Journal of the American College of Cardiology2010，，7： | 1 |
| 10 | Less is more:dimensionality reduction as a general strategy for more precise luminescence thermometry显示文摘Thermal resolution(also referred to as temperature uncertainty)establishes the minimum discernible temperature change sensed by luminescent thermometers and is a key figure of merit to rank them.Much has been done to minimize its value via probe optimization and correction of readout artifacts,but little effort was put into a better exploitation of calibration datasets.In this context,this work aims at providing a new perspective on the definition of luminescence-based thermometric parameters using dimensionality reduction techniques that emerged in the last years.The application of linear(Principal Component Analysis)and non-linear(t-distributed Stochastic Neighbor Embedding)transformations to the calibration datasets obtained from rare-earth nanoparticles and semiconductor nanocrystals resulted in an improvement in thermal resolution compared to the more classical intensity-based and ratiometric approaches.This,in turn,enabled precise monitoring of temperature changes smaller than 0.1℃.The methods here presented allow choosing superior thermometric parameters compared to the more classical ones,pushing the performance of luminescent thermometers close to the experimentally achievable limits. | ERVING XIMENDES RICCARDO MARIN LUIS DIAS CARLOS DANIEL JAQUE | 2022 | Light(Science & Applications)2022，11，9： | 1 |
| 11 | Nonlinear analysis in a Lorenz-like system 显示文摘 | Fabio Scalco Dias Luis Fernando Mello Jian Gang Zhang | 2010 | Nonlinear Analysis : Real World Applications2010，，11： | 1 |
| 12 | Nonlinear analysis in a Lorenz-like system 显示文摘 | Fabio Scalco Dias Luis Femando Mel|o Jiangang Zbang | 2010 | Nonlinear Analysis : Real World Applications2010，，11： | 1 |
| 13 | Liquid–liquid equilibrium of aqueous two-phase systems composed of poly(ethylene oxide) 1500 and different electrolytes ((NH 4 ) 2 SO 4 , ZnSO 4 and K 2 HPO 4 ): Experimental and correlation显示文摘 | Leandro Rodrigues de Lemos Pamela da Rocha Patrício Guilherme Dias Rodrigues Raquel Moreira Maduro de Carvalho Maria C. Hespanhol da Silva Luis Henrique Mendes da Silva | 2011 | Fluid Phase Equilibria2011，，1： | 1 |
| 14 | Dealing with imprecise information in group multi-criteria decisions:a methodology and a GDSS architecture显示文摘 | Dias Luis C Climaco Joao N | 2003 | European Journal of Operational Research2003，148，： | 1 |
| 15 | African-American women have a higher risk for developing peripartum cardiomyopathy显示文摘 | Gentry MB Dias JK Luis A | | 0，，07： | 1 |
| 16 | Joining sheet panels to thin-walled tubular profiles by tube end forming 显示文摘 | Luis M Alves Eduardo J Dias Paulo A F Martins | 2011 | Journal of Cleaner Production2011，，19： | 1 |
| 17 | Functional and patient-reported outcomes of bone-anchored hearing aids (BAHA): A prospective case series study显示文摘Objective:The purpose of this study was to evaluate the functional and patient-reported outcomes,and their correlation,after percutaneous bone-anchored hearing aid(BAHA)implantation.Methods:A prospective study was conducted between January 2018 and December 2020 in a tertiary care center.All adult patients who were implanted with a percutaneous BAHA device during this evaluation period were included in the study.Complete auditory function and patients reported outcome measures(PROMs)were assessed in the preoperative period and 6 months after the implant activation.The PROMs included a generic form(Medical Outcome Study 36 Short Form Healthy Survey(MOS SF-36)),and three disease-specific forms(Hearing Handicap Inventory(HHI),Satisfaction with Amplification in Daily Life Scale(SADLS),and Tinnitus Handicap Inventory(THI)).Results:Twenty-two patients with an average age of 53 years were included in the study.The overall functional gain with the BAHA in sound-field pure tone average(PTA)was 29 dB,with no statistically significant differences according to surgical indication(F(3,18)=2.319,p=0.110).The greater the preoperative air-bone gap,the greater the functional gain obtained(r=0.505,p<0.05).In the PROMs,we found a significant improvement in HHI scores(p<0.005)and a significant increase in overall SADLS scores(p<0.05)with the use of percutaneous BAHA devices.We did not verify any statistically significant correlation between functional and PROMs results.Conclusions:The BAHA is a safe and effective alternative hearing rehabilitation option in selected patients.The PROMs results prove patient's overall satisfaction. | Catia Azevedo Miguel Breda Daniela Ribeiro Fernando Milhazes Mar Sergio Vilarinho Luis Dias | 2023 | Journal of Otology2023，18，1： | 1 |
| 18 | Soy protein concentrate as a protein source for Senegalese sole (Solea senegalensis Kaup 1858)diets:effects on growth and amino acid metabolism of postlarvae显示文摘 | Claudia Aragao Luis E C Conceicao Jorge Dias | 2003 | Aquaculture Research2003，34，： | 1 |
| 19 | Dealing with imprecise information in group multi-criteria decisions:a methodology and a GDSS architecture 显示文摘 | Dias Luis C Chmaco Joao N | 2005 | European Journal of Operational Research2005，160，： | 1 |
| 20 | Assessing Perma- nent Deformation Resistance of High ModulusAsphalt Mix- tures显示文摘 | Capitao Silvino Dias Pieado-- Santos Luis | 2006 | Journal of Transportation Engineer2006，132，5： | 1 |
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