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| 1 | Comparison of high-resolution ultrasound and MR-enterography in patients with inflammatory bowel disease显示文摘AIM:To compare the results of high-resolution ultrasound(HR-US) and magnetic resonance enterography(MRE) examinations in patients with inflammatory bowel disease(IBD).METHODS:The reports of 250 consecutive cases with known IBD,who had an MRE and HR-US examination,were retrospectively analyzed.Using a patient-based approach we evaluated morphological disease features such as affected bowel wall,stenosis,abscess and fistula.The comparison between the two modalities was based on the hypothesis,that any pathological change described in any imaging modality was a true finding,as no further standard of reference was available for complete assessment.RESULTS:Two hundred and fifty examinations representing 207 different patients were evaluated.Both modalities assessed similar bowel wall changes in 65% of the examinations,with more US findings in 11% and more MRE findings in 15%.When the reports were analyzed with regard to 'bowel wall inflammation',US reported more findings in 2%,while MRE reported more findings in 53%.Stenoses were assessed to be identical in 8%,while US found more in 3% and MRE in 29%(P < 0.01).For abscess detection,US showed more findings in 2%(n = 4) while MRE detected more in 6%(n = 16).US detected more fistulas in 1%(n = 2),while MRE detected more in 13%(n = 32)(P < 0.001).The most common reason for no detected pathology by US was a difficult to assess anatomical region(lesser pelvis,n = 72).CONCLUSION:US can miss clinically relevant pathological changes in patients with IBD mostly due to difficulty in assessing certain anatomical regions. | Andreas G Schreyer Cynthia Menzel Chris Friedrich Florian Poschenrieder Lukas Egger Christian Dornia Gabriela Schill Lena M Dendl Doris Schacherer Christl Girlich Ernst-Michael Jung | 2011 | World Journal of Gastroenterology2011，17，8： | 7 |
| 2 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 3 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 4 | Antioxidant treatment with N-acet ylcyst eine and vitamin C in patients with chronic bronchitis显示文摘 | Lukas R Scha rling B Sehultze Weminghaus G | 2005 | Dt sch Med Wochensehr2005，130，11： | 1 |
| 5 | Phase relations in the samarium-poor Sm-Co-Fe system 显示文摘 | Schneider G Henig E -Th Lukas H L | 1985 | J Less-Common Met1985，110，： | 1 |
| 6 | Review of ECMO (extracorporeal membrane oxygenation) support in criti- cally ill adult patients 显示文摘 | MARASCO S F LUKAS G MCDONALD M | 2008 | Heart Lung Circ2008，17，4： | 1 |
| 7 | Risk of recurrence of gastrointestinal stromal tumour after surgery: an analysis of pooled population-based cohorts显示文摘 | Heikki Joensuu Aki Vehtari Jaakko Riihim?ki Toshirou Nishida Sonja E Steigen Peter Brabec Lukas Plank Bengt Nilsson Claudia Cirilli Chiara Braconi Andrea Bordoni Magnus K Magnusson Zdenek Linke Jozef Sufliarsky Massimo Federico Jon G Jonasson Angelo Paolo | 2012 | Lancet Oncology2012，，3： | 1 |
| 8 | Changes in iron-regulatory proteins in the aged rodent neural retina 显示文摘 | Chen H Liu B Lukas T J Suyeoka G Wu G Neufeld AH | 2008 | Neurobiol Aging2008，，： | 1 |
| 9 | Identification of specific relaxin-binding cells in the human female 显示文摘 | Kohsaka T Min G Lukas G | 1998 | Biol Reprod1998，59，4： | 1 |
| 10 | Experimental investigation and thermodynamic calculation of the Al-Mg-Zn system 显示文摘 | LIANG P TARFA T ROBINSON J A WAGNER S OCHIN P HARMELIN M G SEIFERT H J LUKAS H L ALDINGER F | 1998 | Thermochimica Acta1998，314，12： | 1 |
| 11 | Investigation of Al-Mg-Si system by experiments and thermodynamic calculations显示文摘 | Gdecke T Lukas H L | 1997 | J Alloys Compounds1997，247，： | 1 |
| 12 | High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Non-Alcoholic Fatty Liver Disease Progression in Mice显示文摘 | Itziar Fernández-Domínguez J. Javier Echevarria-Uraga Nieves Gómez Zigmund Luka Conrad Wagner Shelly C. Lu José M. Mato Maria L. Martínez-Chantar Juan Rodríguez-Cuesta | 2011 | Ultrasound in Medicine & Biology2011，，7： | 1 |
| 13 | 50 years reaction scheme after Erich Scheil显示文摘 | Lukas H L Henig E T Petzow G | 1986 | Z Metallkd1986，77，： | 1 |
| 14 | The properties of tris(8-hydroxyquinoline)aluminum organic light emitting di-ode with undoped zinc oxide anode layer显示文摘 | Luka G Stakhira P Cherpak V | 2010 | Appl PhysLett2010，108，： | 1 |
| 15 | Austenite-to-ferrite transformation evolution in low alloy steels during thermomechanically controlled process studied by in situ neutron diffraction 显示文摘 | Xu P G Tomota Y Lukas P | 2006 | Materials Science and Engineering A2006，435，： | 1 |
| 16 | On the crystal structure and solubility range on the ternary phase in the Mg-Al-Zn system 显示文摘 | DONNADIEU P QUIVY A TARFA T OCHIN P DEZELLUS A HARMELIN M G LIANG P LUKAS H L SEIFERT H J ALDINGER F EFFENBERG G | 1997 | Z Metallkd1997，88，12： | 1 |
| 17 | of Thought in Organizational Learning 显示文摘 | BELL S J WHITWELL G J LUKAS B A | 2002 | of the Academy of Marketing Science2002，7086，： | 1 |
| 18 | Development of an enzyme-linked immunosorbent assay(ELISA)for detecting IgA antibodies to the Epstein-Barr virus显示文摘 | Uen W C Luka J Pearson G R | 1988 | Int J Cancer1988，41，： | 1 |
| 19 | Schools of thought in organizational learning 显示文摘 | Bell S J Whitwell G J Lukas B A | 2002 | Journal of Academy of Marketing Science2002，30，1： | 1 |
| 20 | Identification of an Epstein-Barr virus early gene encoding a second component of the restricted early antigen complex显示文摘 | Pearson G R Luka J Pett L | 1987 | J Virol1987，160，： | 1 |
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