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| 1 | Strain hardening behavior of Mg-Y alloys after extrusion process显示文摘The strain hardening is an effective mode of enhancing mechanical properties in alloys.In this work,the strain hardening behaviors of Mg-xY(x=1,2,and 3 wt%)after extrusion process was investigated using uniaxial tensile tests.Results suggest that the Mg-xY alloys are composed ofα-Mg with a little amount of Mg24Y5 phase.The average grain size reduces from 19.8μm to 12.2μm as the Y content adds from 1 wt%to 2 wt%.Nevertheless,when Y content reaches 3 wt%,the grain size reaches to 12.9μm,which is close to that of Mg-2Y.The strain hardening rate decreases from 883 MPa to 798 MPa at(σ-σ0.2)=40 MPa,and Mg-2Y and Mg-3Y have the similar strain hardening response.Moreover,Mg-1Y shows an obvious ascending stage after the steep decreasing stage,which is mainly caused by the activation of twinning.The strain hardening behavior of Mg-xY is explained based on understanding the roles of the deformation mechanisms via deformation microstructure analysis and Visco-Plastic Self Consistent(VPSC)model.The variation of strain hardening characteristics with increasing Y content is related to the effects of grain size and texture. | Chaoyue Zhao Ziyan Li Jiahui Shi Xianhua Chen Teng Tu Zhu Luo Renju Cheng Andrej Atrens Fusheng Pan | 2019 | Journal of Magnesium and Alloys2019，7，4： | 6 |
| 2 | PD0325901, an ERK inhibitor, enhances the efficacy of PD-1 inhibitor in non-small cell lung carcinoma显示文摘ERK pathway regulated the programmed death ligand-1(PD-L1)expression which was linked to the response of programmed death-1(PD-1)/PD-L1 blockade therapy.So it is deducible that ERK inhibitor could enhance the efficacy of PD-1 inhibitor in cancer immunotherapy.In this study,PD0325901,an oral potent ERK inhibitor,strongly enhanced the efficacy of PD-1 antibody in vitro and in vivo models in non-small cell lung carcinoma(NSCLC)cells.Mechanistically,PD0325901 or shRNA-ERK1/2 significantly downregulated the PD-L1 expression in NSCLC cells and increased the CD3+T cells infiltration and functions in tumor tissue.There was a positive correlation between the p-ERK1/2 expression and PD-L1 expression in patients with NSCLC.And the patients with low p-ERK1/2 expression were observed a high response rate of PD-1/PD-L1 blockage therapy.Our results demonstrate that PD0325901,an ERK inhibitor,can enhance the efficacy of PD-1 blockage against NSCLC in vitro and in vivo models.And the combination of ERK inhibitor such as PD0325901 and PD-1/PD-L1 blockage is a promising regimen and encouraged to be further confirmed in the treatment of patients with NSCLC. | Min Luo Yuhui Xia Fang Wang Hong Zhang Danting Su Chaoyue Su Chuan Yang Shaocong Wu Sainan An Suxia Lin Liwu Fu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 1 |
| 3 | Antitumor activities of emulsion electrospun fibers with core loading of hydroxycamptothecin via intratumoral implantation显示文摘 | Xiaoming Luo Chengying Xie Huan Wang Chaoyu Liu Shili Yan Xiaohong Li | 2012 | 2012 (1-2)2012，，1： | 1 |
| 4 | 3D printed triboelectric nanogenerator as self-powered human–machine interactive sensor for breathing-based language expression显示文摘Human–machine interfaces(HMIs)are important windows for a human to communicate with the outside world.The current HMI devices such as cellphones,tablets,and computers can be used to help people with aphasia for language expression.However,these conventional HMI devices are not friendly to some particular groups who also lose their abilities of physical movements like in the intensive care unit(ICU)or vegetative patients to realize language expression.Herein,we report a breath-driven triboelectric nanogenerator(TENG)acting as a HMI sensor for language expression through human breathing without voice controls or manual operations.The TENG is integrated within a mask and fabricated via a three-dimensional(3D)printing method.When wearing the mask,the TENG can produce responsive electric signals corresponding to the airflow from breathing,which is capable of recognizing human breathing types with different intensities,lengths,and frequencies.On the basis of the breathing recognition ability,a breathing-based language expressing system is further developed through introducing the Morse code as a communication protocol.Compared with conventional language expressing devices,this system can extract subjective information of a person from breathing behaviors and output corresponding language text,which is not relying on voices or physical movements.This research for the first time introduces the self-powered breathing-based language expressing method to the field of HMI technology by using a 3D printed TENG,and could make HMI interactions become more friendly and fascinating. | Pengcheng Zhu Baosen Zhang Hongyi Wang Yiheng Wu Hengjun Cao Liubing He Chaoyue Li Xuepeng Luo Xing Li Yanchao Mao | 2022 | Nano Research2022，15，8： | 1 |
| 5 | Robust transport of charge carriers in in-plane 1T′-2H MoTe_(2) homojunctions with ohmic contact显示文摘Metal-semiconductor ohmic contacts are required to reduce the energy dissipation for two-dimensional (2D) electronic devices, and phase engineering of 2D transition-metal dichalcogenides (TMDCs) is a promising approach for building ohmic contacts. Here, 2D in-plane 1T′-2H MoTe2 homojunctions were prepared by direct epitaxy via vapor deposition. The interface properties of in-plane 1T′-2H MoTe2 homojunction were investigated in detail by combining experiments, calculations and theories. The ohmic contact properties of 1T′-2H MoTe2 homojunction were proved according to Kelvin force probe microscopy and density functional theory calculations. The charge carriers robust transport in in-plane 1T′-2H MoTe2 homojunction without Fermi-level pinning can be well described by Poisson equation and band alignment. These results indicate that phase engineering of 2D TMDCs is promising to construct ohmic contacts for device applications. | Donglin Lu Zhenqing Li Congsheng Xu Siwei Luo Chaoyu He Jun Li Gang Guo Guolin Hao Xiang Qi Jianxin Zhong | 2021 | Nano Research2021，14，5： | 1 |
| 6 | Chronic Nitrogen Fertilization Modulates Competitive Interactions Among Microbial Ammonia Oxidizers in a Loess Soil显示文摘Nitrogen(N) application may lead to niche segregation of soil ammonia-oxidizing archaea(AOA) and bacteria(AOB), thereby reducing the competitive interactions between AOA and AOB due to higher ammonium substrate availability. However, the adaptive mechanisms of AOA and AOB under N enrichment remain poorly understood. Stable isotope probing(SIP) microcosm incubation was employed to reveal community changes of active AOA and AOB in a loess soil from a field experiment growing potatoes that received no N(control, CK), low N(LN, 75 kg N ha^(-1)), and high N(HN, 375 kg N ha^(-1)). The results showed that the soil potential nitrification rate(PNR) was measured by culturing of the soil samples from the field experiment. Soil PNR was significantly increased in HN by87.5% and 67.5% compared with CK and LN, respectively. Compared with CK, the^(13)C-amoA genes of soil AOA and AOB in HN had 2.58 × 10~4 and 1.55 × 10~6 copies, representing 1.6-and 16.2-fold increase respectively. It was indicated that AOB dominated soil ammonia oxidation. A phylogenetic analysis of the^(13)C-amoA gene showed that N application significantly increased the proportion of54 d9-like AOA up to 90% in HN, while the Nitrososphaera gargensis-like and Nitrososphaera viennensis-like AOA were inhibited and completely disappeared. Nitrogen application also resulted in the community shift of active AOB-dominant group from Nitrosospira briensis-like to Nitrosospira sp. TCH711-like. Our study provides compelling evidence for the emergence and maintenance of active nitrifying communities under the intensified N input to an agricultural ecosystem. | DONG Xingchen ZHANG Jian QIU Huizhen ZHANG He LUO Chaoyue DENG Delei SHEN Qirong JIA Zhongjun | 2019 | Pedosphere2019，29，1： | 0 |
| 7 | PlantCADB:A Comprehensive Plant Chromatin Accessibility Database显示文摘Chromatin accessibility landscapes are essential for detecting regulatory elements,illustrating the corresponding regulatory networks,and,ultimately,understanding the molecular basis underlying key biological processes.With the advancement of sequencing technologies,a large volume of chromatin accessibility data has been accumulated and integrated for humans and other mammals.These data have greatly advanced the study of disease pathogenesis,cancer survival prognosis,and tissue development.To advance the understanding of molecular mechanisms regulating plant key traits and biological processes,we developed a comprehensive plant chromatin accessibility database(PlantCADB)from 649 samples of 37 species.These samples are abiotic stress-related(such as heat,cold,drought,and salt;159 samples),development-related(232 samples),and/or tissue-specific(376 samples).Overall,18,339,426 accessible chromatin regions(ACRs)were compiled.These ACRs were annotated with genomic information,associated genes,transcription factor footprint,motif,and single-nucleotide polymorphisms(SNPs).Additionally,PlantCADB provides various tools to visualize ACRs and corresponding annotations.It thus forms an integrated,annotated,and analyzed plant-related chromatin accessibility resource,which can aid in better understanding genetic regulatory networks underlying development,important traits,stress adaptations,and evolution. | Ke Ding Shanwen Sun Yang Luo Chaoyue Long Jingwen Zhai Yixiao Zhai Guohua Wang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
| 8 | Ductile and high strength Cu fabricated by solid-state cold spray additive manufacturing显示文摘In this work,pure Cu with excellent strength and ductility(UTS of 271 MPa,elongation to fracture of 43.5%,uniform elongation of 30%)was prepared using cold spray additive manufacturing(CSAM),realizing a breakthrough in the field.An in-depth investigation was conducted to reveal the microstructure evolution,strengthening and ductilization mechanisms of the CSAM Cu,as well as the single splats.The results show that the CSAM Cu possesses a unique heterogeneous microstructure with a bimodal grain structure and extensive infinitely circulating ring-mounted distribution of twinning.Based on the single splat observation,the entire copper particle forms a gradient nano-grained(GNG)structure after high-speed impact deposition.The GNG-structured single splat serves as a unit to build the heterogeneous microstructure with bimodal grain distribution during the successive deposition in CSAM.The results also show that CSAM can achieve synergistic strengthening and ductilization by controlling the grain refinement and dislocation density.This work provides potential for CSAM technique in manufacturing various metallic parts with the desired combination of high strength and good ductility without additional post-treatments. | Chaoyue Chen Yingchun Xie Shuo Yin Wenya Li Xiaotao Luo Xinliang Xie Ruixin Zhao Chunming Deng Jiang Wang Hanlin Liao Min Liu Zhongming Ren | 2023 | Journal of Materials Science & Technology2023，，3： | 0 |
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