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| 1 | Chronic Hepatitis B Infection with Low Level Viremia Correlates with the Progression of the Liver Disease显示文摘Background and Aims:Currently,insufficient clinical data are available to address whether low-level viremia(LLV)observed during antiviral treatment will adversely affect the clinical outcome or whether treatment strategies should be altered if LLV occurs.This study compared the clinical out-comes of patients with a maintained virological response(MVR)and patients who experienced LLV and their treatment strategies.Methods:A retrospective cohort of 674 patients with chronic hepatitis B virus(HBV)infection who received antiviral treatment for more than 12 months was analyzed for the development of end-stage liver disease and treatment strategies during the follow-up period.End-stage liver disease included decompensated liver cirrhosis and hepatocellular carcinoma(HCC).Results:During a median 42-month follow-up,end-stage liver disease developed more frequently in patients who experienced LLV than in those who experienced MVR(7.73%and 15.85%vs.0.77%and 5.52%at 5 and 10 years,respectively;p=0.000).The trend was consistent after propensity score matching.In the high-risk group of four HCC risk models,LLV patients had a higher risk of HCC development(p<0.05).By Cox proportional hazard model analysis,LLV was an independent risk factor for end-stage liver disease and HCC(hazard ratio[HR]=6.280,confidence interval[CI]=2.081-18.951,p=0.001;HR=5.108,CI=1.392-18.737,respectively;p=0.014).Patients achieved a lower rate of end-stage liver disease by adjusting treatment compared to continuing the original treatment once LLV occurred(p<0.05).Conclusions:LLV is an independent risk factor for end-stage liver disease and HCC,and treatment adjustments can be considered. | Qian Zhang Hong Peng Xiaoqing Liu Huimin Wang Jinjie Du Xinhua Luo Hong Ren Peng Hu | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 25 |
| 2 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 3 | Fabrication technique of micro/nano-scale speckle patterns with focused ion beam显示文摘The fabrication technique of micro/nano-scale speckle patterns with focused ion beam (FIB) system is studied for digital image correlation (DIC) measurement under a scanning electron microscope (SEM).The speckle patterns are fabricated by directly etching the counterpart of the specimen to the black part of a template.Mean intensity gradient is used to evaluate the quality of these SEM images of speckle patterns fabricated based on different templates to select an optimum template.The pattern size depending on the displacement measurement sensitivity is adjusted by altering the magnification of FIB according to the relation curve of the etching size versus magnification.The influencing factors including etching time and ion beam current are discussed.Rigid body translation tests and rotation tests are carried out under SEM to verify the reliability of the fabricated speckle patterns.The calculated values are in good agreement with the imposed ones. | LI YanJie XIE HuiMin LUO Qiang GU ChangZhi HU ZhenXing CHEN PengWan ZHANG QingMing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 7 |
| 4 | Adsorption of rare earth ions using carbonized polydopamine nano carbon shells显示文摘Herein we reported the structure effects of carbon nano-shells prepared by the carbonization of polydopamine for the adsorption of rare earth elements(REEs) for the first time. Solid carbon spheres, 60 nm carbon shells and 500 nm carbon shells were prepared and evaluated for adsorption and desorption of REEs. The adsorption performance of carbon nano-shells for REEs was far superior to the solid carbon spheres. In addition, the effect of acidity on the adsorption and desorption properties was discussed. The good adsorption performance of the carbon nano-shells could be attributed to their pore structure, specific surface area, and the presence of both amine and carbonyl groups from the grafted dopamine. | 孙晓琦 LUO Huimin Shannon M.Mahurin LIU Rui HOU Xisen DAI Sheng | 2016 | Journal of Rare Earths2016，34，1： | 6 |
| 5 | Annealed microstructure dependent corrosion behavior of Ti-6Al-3Nb-2Zr-1Mo alloy显示文摘Corrosion resistance of titanium(Ti)alloys is closely connected with their microstructure which can be adjusted and controlled via different annealing schemes.Herein,we systematically investigate the specific effects of annealing on the corrosion performance of Ti-6 Al-3 Nb-2 Zr-1 Mo(Ti80)alloy in 3.5 wt.%NaCl and 5 M HCl solutions,respectively,based on open circuit potential(OCP),potentiodynamic polarization,electrochemical impedance spectroscopy(EIS),static immersion tests and surface analysis.Results indicate that increasing annealing tempe rature endows Ti80 alloy with a higher volume fraction ofβphase and finerαphase,which in turn improves its corrosion resistance.Surface characterization demonstrates thatβphase is more resistant to corrosion thanαphase owing to a higher content of Nb,Mo,and Zr in the former;additionally,the decreased thickness of a phase alleviates segregation of elements to further restrain the micro-galvanic couple effects betweenαandβphases.Meanwhile,the influential mechanisms of environmental conditions on corrosion of Ti80 alloy are discussed in detail.As the formation of a highly compact and stable oxide film on surface,annealed Ti80 alloys exhibit a low corrosion current density(10^(-6)A/cm^(2))and high polarization impedance(10^(6)Ω·cm^(2))in 3.5 wt.%NaCl solution.However,they suffer severe corrosion in 5 M HCl solution,resulting from the breakdown of native oxide films(the conversion of TiO_(2)to aqueous Ti^(3+)),active dissolution of substrate Ti to aqueous Ti^(3+)and existence of micro-galvanic couple effects.Those findings could provide new insights to designing Ti alloys with high-corrosion resistance through microstructural optimization. | Baoxian Su Liangshun Luo Binbin Wang Yanqing Su Liang Wang Robert O.Ritchie Enyu Guo Ting Li Huimin Yang Haiguang Huang Jingjie Guo Hengzhi Fu | 2021 | Journal of Materials Science & Technology2021，，3： | 5 |
| 6 | Performances of a Balanced Hydraulic Motor with Planetary Gear Train显示文摘The current research of a balanced hydraulic motor focuses on the characteristics of the motor with three planet gears.References of a balanced hydraulic motor with more than three planet gears are hardly found.In order to study the characteristics of a balanced hydraulic motor with planetary gear train that includes more than three planet gears,on the basis of analysis of the structure and working principle of a balanced hydraulic motor with planetary gear train,formulas are deduced for calculating the hydraulic motor's primary performance indexes such as displacement,unit volume displacement,flowrate fluctuation ratio,etc.Influences of the gears' tooth number on displacement and flowrate characteristics are analyzed.In order to guarantee the reliability of sealing capability,the necessary conditions that tooth number of the sun gear and the planet gears should satisfy are discussed.Selecting large unit volume displacement and small displacement fluctuation ratio as designing objectives,a balanced hydraulic motor with three planet gears and a common gear motor are designed under the conditions of same displacement,tooth addendum coefficien and clearance coefficient.By comparing the unit volume displacement and fluctuation ratio of the two motors,it can be seen that the balanced hydraulic motor with planetary gear train has the advantages of smaller fluctuation ratio and larger unit volume displacement.The results provide theoretical basis for choosing gear tooth-number of this kind of hydraulic motor. | YU Hongying LUO Changjie WANG Huimin | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 4 |
| 7 | As-cast structure refinement of Ti-46Al alloy by hafnium and boron additions显示文摘The influence of Hf and B on the solidifi cation structure of cast Ti-46Al alloys was investigated.The results show that the coupling effect of Hf and B changes the solidifi cation structure morphology and strongl ref ines the grain size.When the Hf+B contents were increased from 0 + 0.0 to 3 + 0.2,5 + 0.6 and 7 + 1.0(in at.%),the solidification structure morphology changed from coarse columnar dendrite to fine columnar dendrite then to equiaxed dendrite,and further to f ine near granular grain whilst the average grain size decreased to 20 μm It is concluded that the columnar dendrite refinement is due to the effect of Hf and B on the decrease of A diffusion coeffi cient in the melt.The f ine near granular grain formation is attributed to the combined constitutiona supercooling formed by Al and B segregation that is strengthened by Hf and B additions at the solid/liquid interface during solidifi cation,and the TiB2 precipitates acting as heterogeneous nuclei. | Zhang Li Su Yanqing Yang Huimin Luo Liangshun Guo Jingjie | 2009 | China Foundry2009，6，2： | 3 |
| 8 | Laser-induced Janus graphene/poly(p-phenylene benzobisoxazole)fabrics with intrinsic flame retardancy as flexible sensors and breathable electrodes for fire-fighting field显示文摘Conventional firefighting clothing and fire masks can protect firemen’s safety to a certain extent,whereas cannot perceive environmental hazards and monitor their physical status in real time.Herein,we fabricated two kinds of Janus graphene/poly(pphenylene benzobisoxazole)(PBO)fabrics by laser direct writing approach and evaluated their performance as intelligent firefighting clothes and fire masks.The results showed that the Janus graphene/PBO fabrics were virtually non-combustible and achieved the highest thermal protection time of 18.91 s ever reported in flame,which is due to the intrinsic flame-retardant nature of PBO fibers.The graphene/PBO woven fabrics-based sensor showed good repeatability and stability in human motion monitoring and NO_(2)gas detection.Furthermore,the piezoelectric fire mask was assembled with graphene/PBO nonwoven fabric as electrode layer and polyvinylidene fluoride(PVDF)electrostatic direct writing film as piezoelectric layer.The filtration efficiency of the fire mask reaches 95%for PM_(2.5)and 100%for PM_(3.0),indicating its effective filtration capability for smoke particles in fires.The respiratory resistance of the piezoelectric fire mask(46.8 Pa)was lower than that of commercial masks(49 Pa),showing that it has good wearing comfort.Besides,the piezoelectric fire mask can be sensitive to the speed and intensity of human breathing,which is essential for indirectly reflecting the health of the human body.Consequently,this work provides a facile approach to fabricate next-generation intrinsic flame-retardant smart textiles for smart firefighting. | Yu Luo Yaping Miao Huimin Wang Kai Dong Lin Hou Yanyan Xu Weichun Chen Yao Zhang Yingying Zhang Wei Fan | 2023 | Nano Research2023，16，5： | 2 |
| 9 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 10 | Shale pore characteristics of Shahejie Formation: Implication for pore evolution of shale oil reservoirs in Dongying sag, north China显示文摘The pore characteristics of shale reservoirs in the lower submember of Member 3 to upper submember of Member 4 of Shahejie Formation in Dongying sag are analyzed,influences of mineral content and organic matter content on porosity and pore size are also investigated,and through the diagenetic thermal simulation experiment,the main pore evolution is further discussed.The results show that the pore structure of shale reservoirs is complex,the micron-nanometer pores can storage liquid hydrocarbons,and the free-phase crude oil is mainly distributed in intergranular dissolution pores of calcite,recrystallized intergranular pores,intergranular shrinkage fractures of clay mineral which have large pore size.Framework minerals and organic matter content directly influence porosity and pore size of shale reservoirs,relationship between porosity and content of felsic mineral as well as content of organic matter content is linear and positive,while relationship between content of carbonated mineral is negative.At the buried depth from 2500 to 3500 m,concentration of organic acid from hydrocarbon generation and expulsion of organic matter,increasing range of pressure coefficient,are well corresponding to highporosity intervals;pore formation in shale oil reservoirs are almost controlled by diagenetic evolution of clay minerals;framework storage spaces formed by carbonate grain crystals as well as intergranular and intergranular dissolution pores of carbonate increases porosity of shale oil reservoirs;local increase of porosity at the depth of 3500e3800 m is mainly caused by coupling of hydrocarbon-generating overpressure and dissolution,and size,distribution and connectivity of pores are enhanced obviously. | Shun Zhang Huimin Liu Min Wang Xinjin Liu Huilai Liu Youshu Bao Weiqing Wang Runze Li Xin Luo Zhengwei Fang | 2019 | Petroleum Research2019，4，2： | 2 |
| 11 | A critical review on lead migration, transformation and emission control in Chinese coal-fired power plants显示文摘Coal is widely utilized as an important energy source,but coal-fired power plant was considered to be an important anthropogenic lead emission source.In the present study,the distribution characteristics of lead in coal and combustion by-products are reviewed.Specifically,lead is mainly transferred to ash particles and the formation and migration mechanisms of particulate lead are summarized.Also,targeted measures are proposed to control the formation of fine particulate lead as well as to increase the removal efficiency during the low-temperature flue gas clean process.In detail,interactions between gaseous lead and some coal-bearing minerals or added adsorbents could obviously suppress the formation of fine particulate lead.On the other hand,some efforts(including promoting capture of fine particles,reducing resistivity of particles and strengthening the gas-liquid contact)could be made to improve the fine particulate lead removal capacity.Notably,the formation mechanism of fine particulate lead is still unclear due to the limitations of research methods.Some differences in the removal principles of fine particles and particulate lead make the lead emission precisely control a great challenge.Finally,the environmental potential risk of lead emission from flue gas and ash residues is addressed and further discussed. | Yicheng Wang Hongyun Hu Xinye Wang Huimin Liu Lu Dong Guangqian Luo Yongchun Zhao Hong Yao | 2023 | Journal of Environmental Sciences2023，，2： | 2 |
| 12 | Novel method for improving control performance in DC micro-grids with distributed generations显示文摘 | LI Weilin LI Huimin LUO Min | 2012 | International Journal of Applied Power Engineering2012，1，1： | 1 |
| 13 | Design of smart MVDC power grid protection显示文摘 | LI Huimin LI Weilin LUO Min | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，9： | 1 |
| 14 | A scientific study on the Xing kiln of ancient China显示文摘Xing kiln was a famous kiln site in Northern China in ancient times for its white porcelain production.Xing kiln was prosperous in Sui and Tang dynasties and declined in Five dynasties.Archaeologists think that Xing kiln of Jin dynasty belonged to Ding kiln genre because of the similar decoration style.In this study,about 470 porcelain shards unearthed from Xing kiln site in Hebei province were analyzed in terms of chemical compositions,firing temperatures,whiteness and physical properties to systemically investigate the technology evolution regularity of Xing kiln from Sui dynasty to Jin dynasty for the first time from science and technology angle,which is also very important to supplement the ancient ceramic history of science and technology in China. | LU XiaoKe LI WeiDong LUO HongJie HAN LiSen WANG HuiMin LI Qiang | 2012 | Science China(Technological Sciences)2012，55，10： | 1 |
| 15 | Design of smart MVDC power grid protection显示文摘 | Li Huimin Li Weilin Luo Min | 2011 | IEEE Transactions on Instrumentation and Measurement2011，60，9： | 1 |
| 16 | Performance of nitrile-containing anions in task-specific ionic liquids for improved CO 2 /N 2 separation显示文摘 | Shannon M. Mahurin Je Seung Lee Gary A. Baker Huimin Luo Sheng Dai | 2010 | Journal of Membrane Science2010，，1： | 1 |
| 17 | Carbon dioxide capture by superbase derived protic ionic liquids显示文摘 | Wang Congmin Luo Huimin Jiang De-en | 2010 | General & Introductory Chemistry:Angewandte Chemic International Edition2010，122，34： | 1 |
| 18 | Tuning the basicity of ionic liquids for equimolar CO2 capture显示文摘 | Wang Congmin Luo Xiaoyan Luo Huimin | 2011 | General & Introductory Chemistry:Angewandte Chemie International Edition2011，50，21： | 1 |
| 19 | The removal of inevitable NOx species in catalysts and the selection of appropriate membrane for measuring electrocatalytic ammonia synthesis accurately显示文摘Ammonia synthesis by electrocatalytic nitrogen reduction reaction(NRR)is considered as a promising alternative to the Haber−Bosch process.However,due to the extremely low ammonia yield and easily accessible extraneous contamination in the laboratory,NRR study always suffers from fluctuation and variability.Finding and eliminating all kinds of possible extraneous contamination is crucial to evaluate the performance of electrocatalytic ammonia synthesis accurately.In this work,we systematically explored two factors that affect NRR results but are easy to be ignored:the selection of membrane for NRR and the unconscious N-source in NRR catalysts.After series of experiments,we proposed a low-cost and almost pollution-free Celgard 3501 membrane as the separator for NRR to avoid the adsorption and release of ammonia by the membrane.In addition,we proposed a pre-reduction strategy to remove residual or adsorbed NOx contaminants in catalysts.These two solutions will help the community to evaluate the NRR activity more accurately. | Huimin Liu Yidan Zhang Jingshan Luo | 2020 | Journal of Energy Chemistry2020，29，10： | 1 |
| 20 | 显示文摘 | Li Guoping Luo Yunjun Tan Huimin | 2005 | Journal of Solid State Chemistry2005，178，4： | 1 |
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