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| 1 | Phase-change composite filled natural nanotubes in hydrogel promote wound healing under photothermally triggered drug release显示文摘It is of great importance to treat a bacterial-infected wound by a smart dressing capable of delivering antibiotics in a smart manner without causing drug resistance.The construction of smart release nanocontainers responsive to near-infrared(NIR)laser irradiation in an on-demand and stepwise way is a promising strategy for avoiding the emergence of multidrug-resistant bacteria.Here,we develop a hydrogel composite made of alginate and nanotubes with an efficient NIR-triggered release of rifampicin and outstanding antibacterial ability.This composite hydrogel is prepared through co-encapsulating antibacterial drug(rifampicin),NIR-absorbing dye(indocyanine green),and phase-change materials(a eutectic mixture of fatty acids)into halloysite nanotubes,followed by incorporation into alginate hydrogels,allowing the in-situ gelation at room temperature and maintaining the integrity of drug-loaded nanotubes.Among them,the eutectic mixture with a melting point of 39℃ serves as the biocompatible phase-change material to facilitate the NIR-triggered drug release.The resultant phase-change material gated-nanotubes exhibit a prominent photothermal efficiency with multistep drug release under laser irradiation.In an in vitro assay,composite hydrogel provides good antibacterial potency against Staphylococcus aureus,one of the most prevalent microorganisms of dangerous gas gangrene.A bacterial-infected rat full-thickness wound model demonstrates that the NIR-responsive composite hydrogel inhibits the bacteria colonization and suppresses the inflammatory response caused by bacteria,promoting angiogenesis and collagen deposition to accelerate wound regeneration.The NIR-responsive composite hydrogel has a great po-tential as an antibacterial wound dressing functionalized with controlled multistep treatment of the infected sites. | Jing-Jing Ye Long-Fei Li Rui-Nan Hao Min Gong Tong Wang Jian Song Qing-Han Meng Na-Na Zhao Fu-Jian Xu Yuri Lvov Li-Qun Zhang Jia-Jia Xue | 2023 | Bioactive Materials2023，，3： | 2 |
| 2 | Assembly of multicomponent protein films by means of electrostatic layer-by-layer adsorption显示文摘 | LVOV Y ARIGA K ICHINOSE I | | 0，，22： | 1 |
| 3 | Correlation between metal catalyst particle size and carbon nanotube growth显示文摘 | KUKOVITSKY E F LVOV S G SAINOV N A | 2002 | Chem Phys Lett2002，355，： | 1 |
| 4 | Assembly of muhicom- ponent protein films by means of electrostatic layer-by- layer adsorption 显示文摘 | Lvov Y Ariga K Ichinose I | 1995 | Journal of the American Chemical Society1995，117，22： | 1 |
| 5 | Pulmonary sustained release of insulin from mieroparticles composed of polyelectrolyte layer-by-layer assembly显示文摘 | Amancha K P Balkundi Shantanu Lvov Yuri | 2014 | International Journal of Pharmaceutics2014，466，12： | 1 |
| 6 | Assembly of multicomponent protein films by means of electrostatic layer-by-layer adsorption显示文摘 | LVOV Y ARIGA K ICHINOSE I | 1995 | J Am Chem Soc1995，117，22： | 1 |
| 7 | An energy model for fatigue life pre- diction of composite materials using continuum damage me- chanics显示文摘 | Movaghghar A Lvov G I | 2012 | Applied Mechanics and Materials2012，，110116： | 1 |
| 8 | Recent Advance in Absolute Analysis by Graphite Furnace Atomic Absorption Spectrometry显示文摘 | LVOV B V | 1990 | Spectrochim Acta1990，52，： | 1 |
| 9 | Deter- mination of optical constants of molecular films assem- bled via alternate polyion adsorption显示文摘 | RAMSDEN J J LVOV YU M DECHER G | 1994 | Thin Solid Fihns1994，254，12： | 1 |
| 10 | Molecular film assembly via layer-by-layer adsorption of oppositely charged macromolecules (linear polymer, protein and clay) and concanavalin A and glycogen显示文摘 | LVOV Y ARIGA K ICHINOSE I | 1996 | Thin Solid Films1996，，： | 1 |
| 11 | Hal- loysite clay nanotubes for controlled release of protec- tive agents 显示文摘 | Lvov Y M Shchukin D G MO hwald H | 2008 | ACS Nano2008，2，5： | 1 |
| 12 | 显示文摘 | Churikov A V Nimon E S Lvov A L | 1997 | Electrochim Acta1997，42，： | 1 |
| 13 | Renormalized waves and discrete breathers in β-Fermi-Pasta-Ulam Chains显示文摘 | GERSHGORIN B LVOV Y V CAI D | 2005 | Phys Rev Lett2005，95，26： | 1 |
| 14 | 显示文摘 | Churikov A V Nimon E S Lvov A L | 1997 | Electrochim Acta1997，42，： | 1 |
| 15 | Halloysite clay nanotubes for controlled release of protective agents显示文摘 | LVOV Y M SHCHUKIN D G M(O)HWALD H | 2008 | ACS nano2008，2，5： | 1 |
| 16 | Advanced Flow-Through External Pressure-Balanced Reference Electrode for Potentiometric and pH Studies in High Temperature Aqueous Solutions 显示文摘 | Lvov S N Gao H Macdonald D D | 1998 | J Electroanal Chem1998，443，2： | 1 |
| 17 | 显示文摘 | Lvov Y ArigaA K Ichinose I | 1995 | J Am Chem Soe1995，117，： | 1 |
| 18 | Cellulose fiber-enzyme composites fabricated through layer-by-layer nanoassembly 显示文摘 | Xing Q Eadula S R Lvov Y M | 2007 | Biornaeromoleeules2007，8，6： | 1 |
| 19 | Molecular characterization of California serogroup viruses isolated in Russia显示文摘 | Vanlandingham D L Davis B S Lvov D K | 2002 | Am J Trop Med Hyg2002，67，： | 1 |
| 20 | Halloysite clay nanotubes for controlled release of protective agents显示文摘 | Lvov Y M Shehukin D G M6hwald H | 2008 | ACS Nano2008，2，5： | 1 |
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