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| 1 | Unusual life-threatening Rosai-Dorfman disease of the trachea. role of NF-kappa B显示文摘 | Zhou, LF Chen, LA Zhu, QA Wang, C Xu, H Cui, XF Jiang, LF He, Ski Huang, M Yin, KS | 2010 | 南京医科大学学报(自然科学版)2010，30，11： | 21 |
| 2 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 3 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 4 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 5 | Sudden hearing loss associated with peginterferon and ribavirin combination therapy during hepatitis C treatment显示文摘在丙肝处理期间与木钉干扰素和 ribavirin 联系的不利效果是众所周知的。突然的听觉损失很少被报导了。包含的可能的机制包括干扰素,汽车免疫,和 hematological 变化的直接 ototoxicity。听觉损失充分经常在抗病毒的治疗的中止以后被解决。我们与长期的丙肝报导一个 47 岁的人,遗传型 2 交流在以木钉干扰素高山开始治疗以后开发了突然的听觉损失 22 wk 哈在 180 mug/wk 和 ribavirin 的剂量的 2a 800 mg 每天。因为症状没变得更坏,抗病毒的治疗为 2 wk 被继续,根据病人的愿望。听见损失在治疗的结束以后在 2 wk 以内解决了。浆液肝丙氨酸 aminotransferase 仍然保持正常在期间并且在抗病毒的治疗的结束以后。HCV RNA 在治疗的结束是无法发现的并且仍然保持否定 24 wk 以后。因此,病人们应该知道听觉损失可以与木钉干扰素治疗,而是决定发生是否继续或到站,治疗基于医生的临床的判断和病人的愿望。 | Héla Elloumi Fatma Houissa Najet Bel Hadj Dalila Gargouri Malika Romani Jamel Kharrat AbdelJabbar Ghorbel | 2007 | World Journal of Gastroenterology2007，13，40： | 4 |
| 6 | Variables associated with the development of complications from radiosurgery of intracranial tumors显示文摘 | Koody H Alexander EIII | 1991 | Int J Radiat Oncol Biol Phys1991，21，： | 1 |
| 7 | Synthetic small inhibiting RNAs:efficient tools to inactivate oncegenic muta-tions and restore p53 pathways显示文摘 | Martinez LA Nagnibneva I Lehrmann H | 2002 | Proc Natl Acad Sci USA2002，99，14： | 1 |
| 8 | Characterization of my coviruses and analyses of chitinase secretion in the biocontrol fungus Metarhizium anisopliae显示文摘 | Gimenez-Pecci M de la Bogo P M R Santi L Moraes C K de Correa C T Vainstein M H Schrank A | 2002 | Current Microbiology2002，45，5： | 1 |
| 9 | The adsorption of gold thiourea complex onto activated carbon 显示文摘 | Zhang H G Ritchie I M La Brooy S R | 2004 | Hydrometallurgy2004，72，： | 1 |
| 10 | The application of exosomes as a nanoscale cancer vaccine 显示文摘 | Tan A H De La Pena Seifalian A M | 2010 | Int J Nanomedicine2010，5，： | 1 |
| 11 | Strontium-89 chloride for pain palliation in prostatic skeletal malignancy 显示文摘 | Laing A H Ackery D M Bayly R J | 1991 | British J Ra- diology1991，64，： | 1 |
| 12 | Regulatory role of p27kip1 in the mouse and human testis显示文摘 | Beumer TL Kiyokawa H Roepers-Gajadien HL van den Bos LA Lock TM Gademan IS Rutgers DH Koff A de Rooij DG | | 0，，： | 1 |
| 13 | Family history of diabetes as a potential public health tool显示文摘 | Harrison TA Hindorff LA Kim H | 2003 | Am J Prev Med2003，24，2： | 1 |
| 14 | 查看详情显示文摘 | Gohil P Evans T E Ferron J R Moyer R A Petty C C Burrell K H Casper T A Garofalo A M Hyatt A W Jayakumar R J Kessel C Kim J Y La Haye R J Lohr J Luce T C Makowski M A Mazon D Menard J Murakami M Politzer P A Prater R Wade M R | | 0，，： | 1 |
| 15 | Comparative study of the spectroscopic properties of Yb3+/Er3+ codoped tellurite glasses modified with R2O(R = Li,Na and K)显示文摘 | DESIRENA H De la ROSA E ROMERO V H | | 0，，02： | 1 |
| 16 | Ceftazidime:pharmacokinetics in patients and effects on the renal function显示文摘 | Norrby SR Bummn LA Liderhdm H | 1982 | J Antimicrob Chemother1982，10，3： | 1 |
| 17 | The anti-emetic efficacy of maropitant(Cerenia)in the treatment of ongoing emesis caused by a wide range of underlying clinical aetiologies in canine patients in Europe显示文摘 | de la Puente-Redondo V A Siedek E M Benchaoui H A | 2007 | J Small Anim Pract2007，48，2： | 1 |
| 18 | Elevated human epididymis protein 4 concentrations inchronic kidney disease显示文摘 | Béla Nagy Jr Krasznai ZT Balla H | 2012 | Ann Clin Biochem2012，49，4： | 1 |
| 19 | Effect of La2O3 doping on the tunable and dielectric properties of BST/MgO composite for microwave tunable application 显示文摘 | LAING R H DONG X L CHEN Y | 2006 | Maoromol Chem Phys2006，，95： | 1 |
| 20 | Prevalence of epilepsy in the elderly:the Rotterdam study显示文摘 | Breteler MM Meinardi H | 1996 | Epilepsia1996，37，： | 1 |
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