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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | The occurrence of DBP in Utah drinking water显示文摘 | Nieminski EC Chaudhuri S Lamoreaux T | 1993 | JAWWA1993，85，： | 2 |
| 3 | Pre-gabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial显示文摘 | ROSENSTOCK J TUCHMAN M LAMOREAUX L | 2004 | Pain2004，110，3： | 1 |
| 4 | Clinical importance of changes in chronic pain intensity measured on an I I-poinl numerical pain rating scale显示文摘 | Farrar JT Young Jr JP Linda LaMoreaux | 2001 | Pain2001，94，2： | 1 |
| 5 | The Casimir force: background, experiments, and applications 显示文摘 | Lamoreaux S K | 2005 | Rep Prog Phys2005，68，： | 1 |
| 6 | The Geography of Invention in the American Glass Industry, 1870 - 1925 显示文摘 | Lamoreaux N Sokoloff K | 1999 | Journal of Economic History1999，，60： | 1 |
| 7 | Gamma knife radiosurgery for vestibular schwannomas: tumor control and functional preservation in 70 patients 显示文摘 | Arthurs BJ Lamoreaux WT Mackay AR et oi | 2011 | Am J Clin Oncol2011，34，3： | 1 |
| 8 | Pregabalin for the treatment of painful diabetic peripheral neuropathy: a double-blind, placebo-controlled trial显示文摘 | Julio Rosenstock Michael Tuchman Linda LaMoreaux Uma Sharma | 2004 | Pain2004，，： | 1 |
| 9 | Pregabalin relieves symptoms of painful diabetic neuropathy:a randomized controlled trial显示文摘 | Lesser H Sharma U Lamoreaux I | | 0，，11： | 1 |
| 10 | Vascular endothelial growth factor increase release of gelatinase A and decrease release of tissue inhibitor of metalloproteinase by microvascular endothelial cells in vitro显示文摘 | Lamoreaux W J Fitzgerald M E Reiner A | 1998 | Microvasc Res1998，55，1： | 1 |
| 11 | Fast, efficient error reconciliation for quantum eryptography显示文摘 | Buttler W T Lamoreaux S K Torgerson J R | 2003 | Phys Rev A2003，67，05： | 1 |
| 12 | Gabap- entin as add-on therapy in children with refractory partial seizures : A 12w,multicentre, double-blind, placebo-controlled study 显示文摘 | Richard Appleton Klaus Fichtner Linda LaMoreaux | 1999 | Epi- lepsia1999，40，8： | 1 |
| 13 | Fast, efficient error reconciliation for quantum cryptography显示文摘 | Buttler W T Lamoreaux S K Torgerson J R | 2003 | Physicals Review A2003，67，05： | 1 |
| 14 | Vascular endothelial growth factor increase release of gelatinase A and decrease release of tissue inhibitor of metalloproteinases by microvascular endothelial cells in vito显示文摘 | Lamoreaux WJ Fitzgerald ME Reiner A | 1998 | Microvas Res1998，55，1： | 1 |
| 15 | Post-SOX Management Influence on Auditor Selectionand Subsequent Impairments of Auditor Independence显示文摘 | Dhaliwal D S Lamoreaux P Lennox C | 2012 | Available at SSRN 20187022012，，： | 1 |
| 16 | Vascular endothelial growth factor increases release of gelatinase A and decreases release of tissue inhibitor of metalloproteinases by microvascular endothelial cell in vitro显示文摘 | Lamoreaux W J Fitzgerald M E Rcinen A | 1998 | Microvasc Res1998，55，1： | 1 |
| 17 | The Casimir force between a gold coated spherical lens and fiat plate显示文摘 | Lamoreaux S K | 1997 | Phy Rev Lett1997，78，1： | 1 |
| 18 | Thermally excited liquid surface waves and their study through the quasielastic scattering of light显示文摘 | KLIPSTEIN W M RADNICH J S LAMOREAUX S K | 1996 | American Journal of Physics1996，64，： | 1 |
| 19 | Clinical outcomes of gamma knife radiosurgery in the salvage treatment of patients with recurrenthigh-grade glioma 显示文摘 | Elaimy AL Mackay AR Lamoreaux WT | 2013 | World Neurosurg2013，80，： | 1 |
| 20 | Clinical importance ofchanges in chronic pain intensity measured on an 11-point humeri-cal pain rating scale 显示文摘 | Farrar JT Yong JP LaMoreaux L | 2001 | Pain2001，94，2： | 1 |
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