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| 1 | 决定新生儿脓毒性休克转归和预后的因素显示文摘背景有关新生儿脓毒性休克转归和预后的资料相对缺乏。目的描述新生儿脓毒性休克的转归,研究与死亡或负面转归相关的因素。设计回顾性队列研究。场所一所大学医院的三级NICU。对象6年期间所有符合下述标准的NICU患儿:证实或高度怀疑感染;伴低血压和(或)需液体复苏或血管活性药物治疗。干预无。测量指标和主要结果主要转归指标为28d病死率,负面转归定义为纠正年龄18个月时确定死亡或存在严重后遗症(脑瘫、严重发育迟缓、听力损害、致盲或短肠综合征)。共有48例患儿纳入研究,其中46例在纠正年龄18个月时获得随访数据。结果发现,28d病死率为40%(19例死亡);24例在纠正年龄18个月时观察到负面转归(病死率为52%;死亡19例,严重后遗症5例)。总计28%的患儿存活且18个月时检查正常。有负面转归的患儿孕周、出生体重、Apgar评分、发生脓毒症时的体质量、pH值均偏低。差异具有显著性。更常见的负面因素包括革兰阴性菌感染、胎儿发育迟缓、低血糖和血小板减少。经多因素分析,对28d病死率和纠正年龄18个月时负面转归较有意义的预测因素是脓毒症发生时体重(OR值分别为0.14、0.21;95%a分别为0.03~0.55、0.06~0.74),以及革兰阴性菌感染(OR值分别为10.1、45.5;95%CI分别为1.5~65.7.3~637)。结论新生儿脓毒性休克的转归很差。研究结果强调极低出生体重儿对脓毒性休克,尤其革兰阴性菌感染所致者抵抗力极差。 | Kermorvant-Duchemin E Laborie S Rabilloud M | 2008 | 中国小儿急救医学2008，15，2： | 2 |
| 2 | Bioengineering bacterial eellulose/poly(ethylene oxide) nanocomposites 显示文摘 | Brown E E Laborie M P G | 2007 | Biomacromolecules2007，8，10： | 1 |
| 3 | Constrt~ction and analysis of a microsatellite-based database of European wheat varieties 显示文摘 | Roder M Wendehake K Korzun V Bredemeijer G Laborie D Bertrand L Isaac P Rendell S Jackson J Cooke R Vosrnan B Ganal M | 2002 | Theoretical and Applied Genetics2002，106，1： | 1 |
| 4 | Surface activation and adhesion properties of wood-fiber reinforced thermoplastic composites 显示文摘 | Gupta B S Laborie M P G | 2007 | Journal of Adhesion2007，83，11： | 1 |
| 5 | Oxyfluorination of wood-fiber rein- forced thermoplastic composites to improve adhesion 显示文摘 | Laborie M Gupta B | 2008 | The Journal of Adhesion2008，84，10： | 1 |
| 6 | Carbon-13 cross-polarization magic-angle-spinning nuclear magnetic resonance investigation of the interactions between maleic anhydride grafted polypropylene and wood polymers显示文摘 | RUDE E LABORIE M P G | 2008 | Applied Spectroscopy2008，62，5： | 1 |
| 7 | Coupling of bipolar membrane eleetrodialysis and ammonia stripping for direct treatment of wastewaters containing ammonium nitrate 显示文摘 | Ali mab Rakib M Laborie S | 2004 | Journal of Membrane Science2004，244，12： | 1 |
| 8 | How slug-flow can improve ultrafiltration flux in organic hollow fibres显示文摘 | Cabassud C Laborie S Lain6 J M | 1997 | Membr Sci1997，128，1： | 1 |
| 9 | Contribution of multivitamins, air, and light in the generation of peroxides in adult and neonatal parenteral nutrition solutions 显示文摘 | Laborie S Lavoie JC Pineault M | 2000 | Ann Pbarmacother2000，34，4： | 1 |
| 10 | How slug flow can improve ultrafiltration flux in organic hollow fibres显示文摘 | Cabassud C Laborie S Lain J M | 1997 | J Membr Sci1997，128，： | 1 |
| 11 | The impact of polypropylene- graft-maleic anhydride on the crystallization and dynamic mechan- ical properties of isotactic polypmpylene 显示文摘 | Harper D P Wolcott M P Laborie | 2009 | Journal of AppliedPolymer Science2009，111，2： | 1 |
| 12 | Bio-based nanocomposites by in situ cure of phenolic prepolymers with cellulose whiskers 显示文摘 | Liu H Z Laborie M P G | | Cellu- lose0，18，3： | 1 |
| 13 | Coupling of bipolar membrane electrodialysis and ammonia stripping for direct treatment of wastwaters containing ammonium nitate显示文摘 | Ben Ali Ma Rakib M Laborie S | 2004 | J Membr Sci2004，244，12： | 1 |
| 14 | Flux enhancement by a continuous tangential gas flow in ultrafiltration hollow fibres for drinking water production:effects of slug flow on cake structure显示文摘 | Laborie S Cabassud C Durand Bourlier Lainé J M | 1997 | Filtration & Separation1997，34，8： | 1 |
| 15 | Oxyfluorination of wood-fiber reinforced thermoplastic composites to improve adhesion显示文摘 | LABORIE M P G GUPTA B | 2008 | Journal of Adhesion2008，84，10： | 1 |
| 16 | How slug can improve ultrafiltration flux in organic hollow fibres显示文摘 | Cabassud C Laborie S Laine J M | 1997 | J Membr Sci1997，128，1： | 1 |
| 17 | Bioengineering bacterial cellulose/poly (ethylene oxide) nanocomposites显示文摘 | BROWN E E LABORIE M P G | 2008 | Biomacromolecules2008，9，12： | 1 |
| 18 | How slug flow can improve ultrafiltration flux in organic hollow fibres 显示文摘 | Cabassud C Laborie S Laine J M | 1997 | Journal of Membrane Science1997，128，1： | 1 |
| 19 | Surface properties and adhesion of wood fiber reinforced thermoplastic composites显示文摘 | Gupta B S Reiniati I Laborie M P G | | 0，，01： | 1 |
| 20 | Oxyfluorination of wood-fiber reinforced thermoplastic composites to improve adhesion显示文摘 | Laborie M P G Gupta B | | 0，，10： | 1 |
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