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104篇 您的检索式:作者名="Laible"
    题名 作者 年代 出处 被引量
1Infection After Spanning External Fixation for High-Energy Tibial Plateau Fractures: Is Pin Site–Plate Overlap a Problem?显示文摘Catherine Laible Emily Earl-Royal Roy Davidovitch Mike Walsh Kenneth A Egol 2012Journal of Orthopaedic Trauma2012,,2:3
2Embryo-mediated genome editing for accelerated genetic improvement of livestock显示文摘Selecting beneficial DNA variants is the main goal of animal breeding.However,this process is inherently inefficient because each animal only carries a fraction of all desirable variants.Genome editing technology with its ability to directly introduce beneficial sequence variants offers new opportunities to modernize animal breeding by overcoming this biological limitation and accelerating genetic gains.To realize rapid genetic gain,precise edits need to be introduced into genomicallyselected embryos,which minimizes the genetic lag.However,embryo-mediated precision editing by homology-directed repair(HDR)mechanisms is currently an inefficient process that often produces mosaic embryos and greatly limits the numbers of available edited embryos.This review provides a summary of genome editing in bovine embryos and proposes an embryo-mediated accelerated breeding scheme that overcomes the present efficiency limitations of HDR editing in bovine embryos.It integrates embryo-based genomic selection with precise multi-editing and uses embryonic cloning with elite edited blastomeres or embryonic pluripotent stem cells to resolve mosaicism,enable multiplex editing and multiply rare elite genotypes.Such a breeding strategy would enable a more targeted,accelerated approach for livestock improvement that allows stacking of beneficial variants,even including novel traits from outside the breeding population,in the most recent elite genetic background,essentially within a single generation.Zachariah MCLEAN Björn OBACK Götz LAIBLE 2020Frontiers of Agricultural Science and Engineering2020,7,2:2
3Meniscal repair 显示文摘Laible C Stein D A Kiridly D N 2013J Am Acad Orthop Surg2013,21,4:1
4The management of respiratory infections during pregnancy 显示文摘Laibl V Sheffield J 2006Immunol Allergy Clin North Am2006,26,1:1
5Formation of chemically bound polymerlayers on oxide surfaces and their role in colloidial stability 显示文摘Laible R K 1980Advances in Colloid and Interface Science1980,,13:1
6Three-dimensional osseo-ligamentous model of the thorax representing initiation of scoliosis by asymmetric growth显示文摘Stokes IA Laible JP 1990J Biomech1990,23,6:1
7Influenza and pneumonia in pregnancy 显示文摘Laibl VR Sheffield JS 2005Clin Pematol2005,32,3:1
8Prevalence of renal dysfunction in ischaemic stroke and transient ischaemic attack patients with or without atrial fibrillation显示文摘Laible M Horstmann S Rizos T 2015Eur J Neurol2015,22,1:1
9A poroelastie finite element model with application to the intervertebral disc 显示文摘Laible JP Paster DS Krag MH 1993Spine1993,18,5:1
10Influenza and pneumonia in pregnancy 显示文摘Laibl VR Sheffield JS 2005Clin Pereatol2005,32,3:1
11SET domain proteins modulate chromatin domains in eu-and heterochromatin显示文摘Jenuwein T Laible G Dorn R etal 1998Cell Mol Life Sci1998,54,1:1
12Towards higher- throughput membrane protein production for structural genomics initiatives显示文摘Laible P D Scott H N Henry L 2004J Struct Funct Genomics2004,5,12:1
13The differential relations of parent and peer attachment to adolescent adjustment显示文摘LAIBLE DJ CARLO G RAFFAELLI M 2000J Youth Adoles2000,29,1:1
14The Differential Relations of Parent and Peer Attachment to Adolescent Adjustment显示文摘Deborah J. Laible Gustavo Carlo Marcela Raffaelli 2000Journal of Youth and Adolescence2000,,1:1
15Coordination between donor cell type and cell cycle stage improves nuclear cloning efficiency in cattle显示文摘DN Wells G Laible FC Tucker 2003Theriogenology2003,59,:1
16Infection after spanning external fixation for high-energy tibial plateau fractures:is pin site-plate overlap a problem?显示文摘Laible C Earl Royal E Davidovitch R 2012J Orthop Trauma2012,26,2:1
17Coordination Between Donor Cell Type and Cell Cycle Stage Improves Nuclear Cloning Ffficiency in Cattle 显示文摘WELLS D N LAIBLE G TUCKER F C 2003Theriogenology2003,59,:1
18Influenza and pneumonia in pregnancy显示文摘Laibl VR Sheffield JS 0,,03:1
19The periprostatic autonomic-nerves bundle or layer?显示文摘Sievert KD Hennenlotter J Laible I 2008Eur Urol2008,54,5:1
203-T high-b-value diffusion-weighted MR imaging in hyperacute ischemic stroke 显示文摘Lettau M Laible M 2013J Neuroradio12013,40,:1
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