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| 1 | Early therapeutic effect of platelet-rich fibrin combined with allogeneic bone marrow-derived stem cells on rats’ critical-sized mandibular defects显示文摘BACKGROUND Critically sized bone defects represent a significant challenge to orthopaedic surgeons worldwide.These defects generally result from severe trauma or resection of a whole large tumour.Autologous bone grafts are the current gold standard for the reconstruction of such defects.However,due to increased patient morbidity and the need for a second operative site,other lines of treatment should be introduced.To find alternative unconventional therapies to manage such defects,bone tissue engineering using a combination of suitable bioactive factors,cells,and biocompatible scaffolds offers a promising new approach for bone regeneration.AIM To evaluate the healing capacity of platelet-rich fibrin(PRF)membranes seeded with allogeneic mesenchymal bone marrow-derived stem cells(BMSCs)on critically sized mandibular defects in a rat model.METHODS Sixty-three Sprague Dawley rats were subjected to bilateral bone defects of critical size in the mandibles created by a 5-mm diameter trephine bur.Rats were allocated to three equal groups of 21 rats each.Group I bone defects were irrigated with normal saline and designed as negative controls.Defects of group II were grafted with PRF membranes and served as positive controls,while defects of group III were grafted with PRF membranes seeded with allogeneic BMSCs.Seven rats from each group were killed at 1,2 and 4 wk.The mandibles were dissected and prepared for routine haematoxylin and eosin(HE)staining,Masson's trichrome staining and CD68 immunohistochemical staining.RESULTS Four weeks postoperatively,the percentage area of newly formed bone was significantly higher in group III(0.88±0.02)than in groups I(0.02±0.00)and II(0.60±0.02).The amount of granulation tissue formation was lower in group III(0.12±0.02)than in groups I(0.20±0.02)and II(0.40±0.02).The number of inflammatory cells was lower in group III(0.29±0.03)than in groups I(4.82±0.08)and II(3.09±0.07).CONCLUSION Bone regenerative quality of critically sized mandibular bone defects in rats was better promoted by PRF membranes seeded with BMSCs than with PRF membranes alone. | Muhammad A Awadeen Fouad A Al-Belasy Laila E Ameen Mohamad E Helal Mohammed E Grawish | 2020 | World Journal of Stem Cells2020，12，1： | 4 |
| 2 | A refined Hilbert- Huang transform with applications to interarea oscillation monitoring 显示文摘 | Laila D S Messina A R Pal B C | 2009 | IEEE Trans on Power Systems2009，24，2： | 1 |
| 3 | A refined hilbert-huang transform with applications to interarea oscillation monitoring显示文摘 | Laila D Messina A Pal B | 2009 | IEEE Transactions on Power Systems2009，24，2： | 1 |
| 4 | Metabolic, Endocrine, and immune con- sequencesof sleep deprivation 显示文摘 | Laila A Ahmed S B | 2011 | Open Respir Med2011，，5： | 1 |
| 5 | Nuclear issues and analysis for ARIES spherical and advanced tokamaks显示文摘 | Laila A El-Guebaly | 2000 | Fusion Engineering and Design2000，5152，： | 1 |
| 6 | Gender-specific association of the angiotensin converting enzyme gene with Alzheimer' s disease显示文摘 | Fiona C Laila A John S | | 0，，： | 1 |
| 7 | ARIES-ST nuclear analysis and shild design显示文摘 | Laila A El-Guebaly | 2003 | Fusion Engineering and Design2003，65，： | 1 |
| 8 | Electronic Structure and Chemical Bonding in Half-Heusler Phases 显示文摘 | Laila Offernes Ravindran P Kjekshus A | 2007 | Journal of Alloys and Compounds2007，439，： | 1 |
| 9 | The tin-rich part of the Au-Pt-Sn system 显示文摘 | Alexandra N T Laila Offernes Kjekshus A | 2001 | Journal of Alloys and Compounds2001，314，12： | 1 |
| 10 | 5,5-Dimethyl1,2,3-cyclohexanetrione 1,2-dioxime 3-thiosemicarbazone as a reagent for the spectrophotometric determination of nickel and copper显示文摘 | SALIM R LAILA A H QAMHIEH A | 1988 | Spectroscopy Letters1988，21，7： | 1 |
| 11 | Impact of the socioeconomic status on the severity and outcome of community-acquired pneumonia among Egyptian children: a cohort study显示文摘Background:Community-acquired pneumonia(CAP)is one of the five leading causes of death among children in developing countries,accounting for approximately three million deaths per year.Identification of the modifiable risk factors of CAP may help to reduce the burden of this disease.In this study,the impact of the socioeconomic status(SES)on the severity and outcome of CAP among Egyptian children was studied.Methods:This was a prospective longitudinal cohort study which included 1,470 children diagnosed with CAP,aged two to 15 years(median age 5.4 years).The diagnosis of CAP was based on clinical and radiological findings.A structured questionnaire and the patients’medical records were used for the data collection.The subjects were divided into two groups:mild and severe CAP.Social and demographic variables were compared,and a multivariate logistic regression analysis was performed.Results:The multivariate analysis showed that a low maternal education level(OR:3.8;95%CI:2.12-6.70;P=.0001),unavailability of adequate medical care(OR:3.1;95%CI:1.99-4.88;P=.0001),a low family income(OR:2.2;95%CI:0.99-4.78;P=.047),and parents’smoking habits(OR:2.0;95%CI:1.15-3.55;P=.014)were significant independent predictive risk factors for severe CAP among Egyptian children.Conclusion:Public health measures against these socio-demographic risk factors should be identified as priorities in order to help reduce the disease burden of deaths from severe CAP among Egyptian children. | Seham Fathy Abdel Hameed Azab Laila M Sherief Safaa H Saleh Wafaa F Elsaeed Mona A Elshafie Sanaa M Abdelsalam | 2014 | Infectious Diseases of Poverty2014，3，1： | 1 |
| 12 | Identifi-cation of potent antioxidant bioactive peptides from goat milk proteins显示文摘 | AHMED S A TAWFIKEL-BASSIONY LAILA M E | 2015 | Food Research International2015，74，2： | 1 |
| 13 | 显示文摘 | Abdel-Ghaffar A Ali Laila I Ali Sameh M Aboul-Fotouh | 2001 | Apllied Catalysis A:General2001，215，： | 1 |
| 14 | Ra-dioprotective effects of silymarin显示文摘 | LAILA A A RAMADAN HAMED M ROUSHDY GAMAL M | 2002 | Pharmacological Research2002，45，6： | 1 |
| 15 | A refined Hilbert-Huang transform with applications to interarea oscillation monitoring显示文摘 | LAILA D S MESSINA A R PAL B C | 2009 | IEEE Trans on Power Systems2009，24，2： | 1 |
| 16 | Purification and identificationof novel antioxidant peptides from enzymatic hydrolysates ofsardinelle (Sardinellaaurita) by-products proteins显示文摘 | ALI B NAIMA N A LAILA M | 2010 | Food Chemistry2010，118，3： | 1 |
| 17 | Hydrogenation of aromatics on modified platinum-alumina catalysts显示文摘 | Ali Abdel-Ghaffar A Ali Laila I Aboul-Fotouh S M | 1998 | Appl Catal A: General1998，170，2： | 1 |
| 18 | Chemical Proper-ties of Processed Ras Cheese Spreads as Affected by Emulsifying Salt 显示文摘 | Laila B Abdel-Hamid S A E1-Shabrawy R A Awad | 2002 | Journal of Food Processing Preservation2002，24，： | 1 |
| 19 | Protozoan parasites in irritable bowel syndrome:A case-control study显示文摘AIM To investigate the putative role of protozoan parasites in the development of irritable bowel syndrome(IBS).METHODS The study included 109 IBS consecutive adult patients fulfilling the Rome Ⅲ criteria and 100 healthy control subjects. All study subjects filled a structured questionnaire, which covered demographic information and clinical data. Fresh stool samples were collected from patients and control subjects and processed within less than 2 h of collection. Iodine wet mounts and Trichrome stained smears prepared from fresh stool and sediment concentrate were microscopically examined for parasites. Blastocystis DNA was detected by polymerase chain reaction, and Cryptosporidium antigens were detected by ELISA.RESULTS A total of 109 IBS patients(31 males, 78 females) with a mean age ± SD of 27.25 ± 11.58 years(range: 16-60 years) were enrolled in the study. The main IBS subtype based on the symptoms of these patients was constipation-predominant(88.7% of patients). A hundred healthy subjects(30 males, 70 females) with a mean ± SD age of 25.0 ± 9.13 years(range 18-66 years) were recruited as controls. In the IBS patients, Blastocystis DNA was detected in 25.7%, Cryptosporidium oocysts were observed in 9.2%, and Giardia cysts were observed in 11%. In the control subjects, Blastocystis, Cryptosporidium and Giardia were detected in 9%, 0%, and 1%, respectively. The difference in the presence of Blastocystis(P = 0.0034), Cryptosporidium(P = 0.0003), and Giardia(P = 0.0029) between IBS patients and controls was statistically significant by all methods used in this study.CONCLUSION Prevalence of Blastocystis, Cryptosporidium and Giardia is higher in IBS patients than in controls. These parasites are likely to have a role in the pathogenesis of IBS. | Khaled A Jadallah Laila F Nimri Rola A Ghanem | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，4： | 1 |
| 20 | Progressive ureteral dilation for subsequent ureterocystoplasty显示文摘 | Cilento B Atala A | 1996 | J Urol1996，156，： | 1 |
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