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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Development and valida- tion of a primary care-based family health history and decision sup- port program (MeTree)显示文摘 | Orlando LA Buchanan AH Hahn SE | 2013 | N C Med J2013，74，4： | 1 |
| 3 | Diagnosing and co-managing patients with obstructive sleep apnea syndrome显示文摘 | Friedlander AH Walker LA | 2000 | J Am Dent Assoc2000，131，8： | 1 |
| 4 | Relationship between postoperative anaemia and cardiac morbidity in high-risk vascular patients in the intensive care unit显示文摘 | Nelson AH Fleisher LA Rosenbaum SH | 1993 | Crit Care Med1993，21，： | 1 |
| 5 | Mechanisms of the pathogenesis of troponin T-based familial hypertrophic cardiomyopath 显示文摘 | Maass AH Leinwand LA | 2003 | Trends Cardiovasc Med2003，13，6： | 1 |
| 6 | The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma:a multicenter study显示文摘 | Hefler LA Rosen AC Graf AH | 2000 | Cancer2000，89，7： | 1 |
| 7 | The clinical value of serum concentrations of cancer antigen 125 in patients with primary fallopian tube carcinoma: a multicenter study 显示文摘 | Hefler LA Rosen AC Graf AH | 2000 | Cancer2000，89，7： | 1 |
| 8 | Role of p38 and JNK in liver ischemia and reperfusion显示文摘 | King LA Toledo AH Rivera-Chavez FA | 2009 | J Hepatobiliary Panereat Surg2009，16，6： | 1 |
| 9 | Diagnosing and comanaging patients with obstructive sleep apnea syndrome 显示文摘 | Friedlander AH Walker LA Friedlander IK | 2000 | Am Dent Assoc2000，131，8： | 1 |
| 10 | Endothelial control of arterial distensibility is impaired in chronic heart failure显示文摘 | Ramsey MW Goodfellow J Jones Cj Luddington LA lewis MJ Henderson AH | 1995 | Circulation1995，92，11： | 1 |
| 11 | Strict glycaernic control in patients hospitalised in a mixed medical and surgical intensive care unit: a randomised clinical trial 显示文摘 | De La Rosa Gdel C Donado 1H Restrepo AH | 2008 | Crit Care2008，12，5： | 1 |
| 12 | Carboplatin dosage:prospective evaluation of a simple formula based on renal function显示文摘 | Calvert AH Newell DR Gumbrell LA | 1989 | J Clin Oncol1989，7，： | 1 |
| 13 | Limited tissue penetration of taxanes: a mechanism for resistance in solid tumors显示文摘 | Kyle AH Huxham LA Yeoman DM | 2007 | Clin Cancer Res2007，13，9： | 1 |
| 14 | Familial myelodysplastic syndrome/acute leukemia syndromes: a review and utility for translational investigations显示文摘 | West AH Godley LA Churpek JE | 2014 | Ann N Y Acad Sci2014，1310，： | 1 |
| 15 | Strontium-89 chloride for pain palliation in prostatic skeletal malignancy显示文摘 | Laing AH Ackery DM Bayly R J | | 0，，765： | 1 |
| 16 | Retrospective analysis of catheter-re- lated infections in a hemodialysis unit 显示文摘 | Colville LA Lee AH | 2006 | Infect Control Hosp Epidemio12006，27，9： | 1 |
| 17 | Development and validation of a primary care-based family health history and decision support program (MeTree)显示文摘 | Orlando LA Buchanan AH Hahn SE | 2013 | N C Med J2013，74，4： | 1 |
| 18 | Endosseous implant placement in conjunction with inferior alveolar nerve transposition: A report of an unusual complication and surgical management显示文摘 | Luna AH Passeri LA de Moraes M | 2008 | Int J Oral Maxillofac Implants2008，23，1： | 1 |
| 19 | Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomas显示文摘 | Meza-Zepeda LA Kresse SH Barragan-Polania AH | 2006 | Cancer Res2006，66，18： | 1 |
| 20 | Strict glycaemic control in patients hospitalised in a mixed medical and surgical intensive care unit:a randomised clinical trial显示文摘 | De La Rosa Gdel C Donado JH Restrepo AH | | Critical Care0，，： | 1 |
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