|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human hepatic sinusoidal endothelial cells can be distinguished by expression of phenotypic markers related to their specialised functions in vivo显示文摘The hepatic sinusoids are lined by a unique population of hepatic sinusoidal endothelial cells (HSEC), which is one of the first hepatic cell populations to come into contact with blood components. However, HSEC are not simply barrier cells that restrict the access of blood- borne compounds to the parenchyma. They are func- tionally specialised endothelial cells that have complex roles, including not only receptor-mediated clearance of endotoxin, bacteria and other compounds, but also the regulation of inflammation, leukocyte recruitment and host immune responses to pathogens. Thus understand- ing the differentiation and function of HSEC is critical for the elucidation of liver biology and pathophysiology. This article reviews methods for isolating and studying human hepatic endothelial cell populations using in vitro models. We also discuss the expression and functions of phe- notypic markers, such as the presence of fenestrations and expression of VAP-1, Stabilin-1, L-SIGN, which can be used to identify sinusoidal endothelium and to permit discrimination from vascular and lymphatic endothelial cells. | PF Lalor SM Curbishley S Shetty DH Adams | 2006 | World Journal of Gastroenterology2006，12，34： | 11 |
| 2 | Hepatic expression and cellular distribution of the glucose transporter family显示文摘Glucose and other carbohydrates are transported into cells using members of a family of integral membrane glucose transporter (GLUT) molecules. To date 14 members of this family, also called the solute carrier 2A proteins have been identified which are divided on the basis of transport characteristics and sequence similarities into several families (Classes 1 to 3). The expression of these different receptor subtypes varies between different species, tissues and cellular subtypes and each has differential sensitivities to stimuli such as insulin. The liver is a contributor to metabolic carbohydrate homeostasis and is a major site for synthesis, storage and redistribution of carbohydrates. Situations in which the balance of glucose homeostasis is upset such as diabetes or the metabolic syndrome can lead metabolic disturbances that drive chronic organ damage and failure, confirming the importance of understanding the molecular regulation of hepatic glucose homeostasis. There is a considerable literature describing the expression and function of receptors that regulate glucose uptake and release by hepatocytes, the most import cells in glucose regulation and glycogen storage. However there is less appreciation of the roles of GLUTs expressed by non parenchymal cell types within the liver, all of which require carbohydrate to function. A better understanding of the detailed cellular distribution of GLUTs in human liver tissue may shed light on mechanisms underlying disease pathogenesis. This review summarises the available literature on hepatocellular expression of GLUTs in health and disease and highlights areas where further investigation is required. | Sumera Karim David H Adams Patricia F Lalor | 2012 | World Journal of Gastroenterology2012，18，46： | 5 |
| 3 | The Pressor Effect of Moderate Alcohol Consumption in Man: A Search for Mechanisms显示文摘 | PETER D. ARKWRIGHT LAWRENCE J. BEILIN ROBERT VANDONGEN IAN A. ROUSE CLAIRE LALOR | 1982 | Circulation1982，，3： | 2 |
| 4 | Investigation of dry-weather pollurant entries into storm-drainage systems显示文摘 | Field R Pitt R Lalor M | 1994 | Journal of Environmental Engineering1994，120，5： | 1 |
| 5 | Spatiotemporalphase unwrapping for the measurement of discontinuousobjects in dynamic fringe-projection phase-shifting pro-filometry显示文摘 | ZHANG H LALOR M BERTON D | 1999 | Appl Opt1999，38，16： | 1 |
| 6 | T cells in mul-tiple sclerosis and experimental autoimmune encephalo-myelitis显示文摘 | Fletcher JM Lalor SJ Sweeney CM | 2010 | Clin Exp Immunol2010，162，1： | 1 |
| 7 | Activation of vascular adhesion protein-1 on liver endothelium results in an NF-kappaB-dependent increase in lymphocyte adhesion显示文摘 | Lalor P Sun P Weston C | | 0，，： | 1 |
| 8 | Frequency control in competitive electricity market dispatch显示文摘 | Ronan Doherty Gillian Lalor Malley M O | 2005 | IEEE Trans on Power Systems2005，20，3： | 1 |
| 9 | Comparison of bauxites from Jamaica, the Dominican Republic and Suriname 显示文摘 | Grant C N Lalor G C Vutchkov M K | 2005 | Journal of Radioanalytical and Nuclear Chemistry2005，266，3： | 1 |
| 10 | Analysis of Interior Acoustic Fields Using the Finite Element Method and the Boundary Element Method显示文摘 | KOPUZ S LALOR N | 1995 | Applied Acoustics1995，45，3： | 1 |
| 11 | Texture Orientation and Anisotropy Calculation by Fourier Transform and Principal Component Analysis显示文摘 | Josso B Burton D R Lalor M J | 2005 | Mechanical Systems and Signal Processing2005，19，5： | 1 |
| 12 | Activation of vascular adhesion protein-1 on liver endothelium results in an NF kappaB-dependent increase in lymphesion显示文摘 | Lalor PF Sun PJ Weston CJ | 2007 | Hepatology2007，45，2： | 1 |
| 13 | Distinct Roles for CCR4 and CXCR3 in the Recruitment and Positioning of Regulatory T Cells in the Inflamed Human Liver显示文摘 | OO Y H WESTON C J LALOR P F | 2010 | J Immunol2010，184，6： | 1 |
| 14 | A Reivew of Low Noise Diesel Engine Design at ISVR显示文摘 | Grover E C Lalor N | 1973 | Journal of Sound and Vibration1973，28，3： | 1 |
| 15 | Frequency control and wind turbine technologies显示文摘 | Lalor G Mullane A O'Matley M | | 0，，04： | 1 |
| 16 | Frequency control and wind turbine technologies 显示文摘 | LALOR G MULLANE A MALLEY M O | 2005 | IEEE Trans on Power Systems2005，20，4： | 1 |
| 17 | Investigation of dry-weather pollutant entries into storm-drainage systems 显示文摘 | Field R Pitt R Lalor M | 1994 | J Environ Eng1994，120，5： | 1 |
| 18 | CXC Chemokine Ligand 16 Promotes Integrin - Mediated Adhesion of Liver - Infiltrating Lymphocytes to Chlanglocytes and Hepatocytes within the Intlamed Human Liver显示文摘 | Heydtmann M Lalor P Ekstan J | 2005 | J Immunol2005，174，： | 1 |
| 19 | Inhibition of ERK MAPK suppresses IL-23-and IL-l-driven IL-17 production and attenuates autoimmune disease显示文摘 | Brereton CF Sutton CE Lalor S J | 2009 | J Immunol2009，183，： | 1 |
| 20 | Cadmium levels in kidney and liver of Jamaicans at autopsy显示文摘 | LALOR G C RATTRAY R WILLIAMS N | 2004 | The West Indian Medical Journal2004，53，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员