|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 2 | The pharmacoepidemiolo-gy of selective serotonin reuptake inhibitors for children and adolescents in Canada from 2005 to 2009: a database analysis 显示文摘 | Lam D Gorman DA Patten S etal | 2013 | Paediatr Drugs2013，15，4： | 1 |
| 3 | A new copper acetate-bis(oxazoline)-catalyzed,enantioselective Henry reaction 显示文摘 | EVANS DA MAGNUS RDS LAM H W | 2003 | J Am ChemSoc2003，125，12： | 1 |
| 4 | The imporance of process issues as predictors of time to endoscopy in patients with acute upper-GI bleeding using the RUGBE data 显示文摘 | DA SILVERIA EB LAM E MARIEL M | 2006 | Gastrointest Endose2006，64，3： | 1 |
| 5 | Modeling seasonality in fecundability, conceptions, and births显示文摘 | Lam DA Miron JA Riley A | 2002 | Demography2002，31，： | 1 |
| 6 | In situ assembly of enzyme inhibitors using extend tethering显示文摘 | Erlanson DA Lam JW Deckwerth C | 2003 | Nature Biotecholoby2003，21，： | 1 |
| 7 | Visual loss from idiopathic in- tracranial pachymeningitis 显示文摘 | Lam BL Barrett DA Glaser JS | 1994 | Neurology1994，44，： | 1 |
| 8 | Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder显示文摘 | VYTHILINGAM M LUCKENBAUGH DA LAM T | | 0，，02： | 1 |
| 9 | Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder显示文摘 | Vythilingam M Luckenbaugh DA Lam T | | 0，，02： | 1 |
| 10 | 查看详情显示文摘 | Katz A Da Costa P Chun Pong Lam A Notestein J M | | 0，，： | 1 |
| 11 | Health literacy and an-tiretroviral adherence among HIV-infected adolescents显示文摘 | Murphy DA Lam P Naar-King S | 2010 | PatientEducation and Counseling2010，79，1： | 1 |
| 12 | Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan显示文摘 | Howitz KT Bitterman KJ Cohen HY Lamming DW Lavu S Wood JG Zipkin RE Chung P Kisielewski A Zhang LL Scherer B Sinclair DA | 2003 | Nature2003，1425，6954： | 1 |
| 13 | The first single-step immobilization of a Calix--arene onto the surface of silica显示文摘 | KATZ A DA COSTA P LAM A C P NOTESTEIN J M | 2002 | Chem Mater2002，14，8： | 1 |
| 14 | Visual loss from idiopathic intracranial pachyminingitis显示文摘 | Lam BL Barrett DA Glaser JS | 1994 | Neurology1994，44，： | 1 |
| 15 | Semi-rigid action of composite joints显示文摘 | Lam D Nethercot DA | 1990 | The Structural Engineer1990，24，18： | 1 |
| 16 | Semi-rigid action of composite joints显示文摘 | Lam D Nethercot DA | 1990 | Structural Engineer1990，68，24： | 1 |
| 17 | The first single-step immobilization of a calix--arene onto the surface of silica显示文摘 | Katz A Da Costa P Lam A C P | 2002 | Chem Mater2002，14，8： | 1 |
| 18 | The importance of process issues as predictors of time to endoscopy in patients with acute upper-GI bleeding using the RUGBE data显示文摘 | da Silveria EB Lam E Martel M | 2006 | Gastrointest Endosc2006，，3： | 1 |
| 19 | Visual loss from idiopathic in- tracranial pachymeningitis 显示文摘 | Lam BL Barrett DA Glaser JS | 1994 | Neurology1994，44，4： | 1 |
| 20 | Contributions of antinucleoprotein IgG to heterosubtypic immunity against influenza virus 显示文摘 | Lamere MW Lam HT Moquin A Haynes L Lund FE Randall TD Kaminski DA | 2011 | J Immunol2011，186，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员