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| 1 | Osteoblasts are inherently programmed to repel sensory innervation显示文摘Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons.Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development.Yet,the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still limited.Here,we demonstrated that differentiation of human mesenchymal stem cells to osteoblasts leads to a marked impairment of their ability to promote axonal growth,evidenced under sensory neurons and osteoblastic-lineage cells crosstalk.The mechanisms by which osteoblast lineage cells provide this nonpermissive environment for axons include paracrine-induced repulsion and loss of neurotrophic factors expression.We identified a drastic reduction of NGF and BDNF production and stimulation of Sema3A,Wnt4;and Shh expression culminating at late stage of OB differentiation.We noted a correlation between Shh expression profile,OB differentiation stages,and OB-mediated axonal repulsion.Blockade of Shh activity and signaling reversed the repulsive action of osteoblasts on sensory axons.Finally,to strengthen our model,we localized the expression of Shh by osteoblasts in bone tissue.Overall,our findings provide evidence that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation,and highlight osteoblast-derived Shh as an essential player in this cue-induced regulation. | Luis Leitao Estrela Neto Francisco Conceicao Ana Monteiro Marina Couto Cecilia JAlves Daniela MSousa Meriem Lamghari | 2020 | Bone Research2020，8，3： | 4 |
| 2 | Leptin effect on RANKL and OPG expression in MC3T3-E1 osteoblasts 显示文摘 | Lamghari M Tavares L Camboa N Barbosa M A | 2006 | J Cell Biochem2006，98，5： | 1 |
| 3 | Stimulation of bone marrow cells and bone formation by nacre: in vivo and in vitro studies显示文摘 | Lamghari M Almeida MJ Berland S | 1999 | Bone1999，25，2： | 1 |
| 4 | Nutritional value of proteins from edible seaweed Palmaria palmata (Dulse)显示文摘 | GALLAND-IRMOULI A V FLEURENCE J LAMGHARI R | 1999 | Journal of Nutritional Biochemistry1999，10，6： | 1 |
| 5 | A model for evaluating injectable hone replacements in the vertebrae of sheep:radiological and histological study显示文摘 | Lamghari M Huet H Laurent A | 1999 | Biomaterials1999，20，22： | 1 |
| 6 | Nutritional value of proteins fi:om edible seaweedPalmaria palmata(Dulse)显示文摘 | Galland-Irmouli A V Fleurence J Lamghari R | 1999 | Journal of Nutritional Biochemistry1999，10，6： | 1 |
| 7 | Sympathetic activity in breast cancer and metastasis:partners in crime显示文摘The vast majority of patients with advanced breast cancer present skeletal complications that severely compromise their quality of life.Breast cancer cells are characterized by a strong tropism to the bone niche.After engraftment and colonization of bone,breast cancer cells interact with native bone cells to hinder the normal bone remodeling process and establish an osteolytic“metastatic vicious cycle”.The sympathetic nervous system has emerged in recent years as an important modulator of breast cancer progression and metastasis,potentiating and accelerating the onset of the vicious cycle and leading to extensive bone degradation.Furthermore,sympathetic neurotransmitters and their cognate receptors have been shown to promote several hallmarks of breast cancer,such as proliferation,angiogenesis,immune escape,and invasion of the extracellular matrix.In this review,we assembled the current knowledge concerning the complex interactions that take place in the tumor microenvironment,with a special emphasis on sympathetic modulation of breast cancer cells and stromal cells.Notably,the differential action of epinephrine and norepinephrine,through eitherα-orβ-adrenergic receptors,on breast cancer progression prompts careful consideration when designing new therapeutic options.In addition,the contribution of sympathetic innervation to the formation of bone metastatic foci is highlighted.In particular,we address the remarkable ability of adrenergic signaling to condition the native bone remodeling process and modulate the bone vasculature,driving breast cancer cell engraftment in the bone niche.Finally,clinical perspectives and developments on the use ofβ-adrenergic receptor inhibitors for breast cancer management and treatment are discussed. | Francisco Conceição Daniela M.Sousa Joana Paredes Meriem Lamghari | 2021 | Bone Research2021，9，1： | 1 |
| 8 | Rat bone marrow stromal cell osteogenic differentiation and fibronectin adsorption on chitosan membranes : the effect of the degree of acetylation 显示文摘 | Amaral IF Lamghari M Sousa SR | 2005 | J Biomed Mater Res A2005，75，2： | 1 |
| 9 | Rat bone marrow stromal cell osteogenic differentiation and fibronectin adsorption on chitosan membranes:the effect of the degree of acetylation显示文摘 | Amaral I F Lamghari M Sousa S R | 2005 | J Biomed Mater Res A2005，75，2： | 1 |
| 10 | Bone Reactions to Nacre Injected Percutaneously into the Vertebrae of Sheep 显示文摘 | Lamghari M Berland S Laurent A | 2001 | Biomaterials2001，22，6： | 1 |
| 11 | Stimulation of bone marrow cells and bone formation by nacre:in vivo and in vitro studies显示文摘 | Lamghari M Almeida M J Lopez E | 1999 | Bone1999，25，2： | 1 |
| 12 | A magneto-thermal study of a high-speed synchronous reluc- tance machine 显示文摘 | Lamghari Jamal M I Fouladgar J Zaim E H | 2006 | IEEE Transactions on Magnetics2006，42，3： | 1 |
| 13 | Nutritional value of proteins from edible seaweed Palmaria palmata(Dulse) 显示文摘 | Galland-Irmouli A V Fleurence J Lamghari R | 1999 | J Nutr Biochem1999，10，： | 1 |
| 14 | A magneto-thermal study of a high-speed synchronous reluctance machine显示文摘 | Lamghari Jamal M I Fouladgar J Zaim E H | 2006 | IEEE Transactions on Magnetics2006，42，3： | 1 |
| 15 | Rat bone marrow stromal cell osteogenic differentiation and fibronectin adsorption on chitosan membranes: the effect of the degree of acetylation 显示文摘 | Amaral IF Lamghari M Sousa SR | 2005 | J Biomed Mater Res A2005，75，2： | 1 |
| 16 | A model for evaluating injectable bone replacements in the vertebrae of sheep: radiological and histological study 显示文摘 | Lamghari M Huet H Laurent A | 1999 | Biomaterials1999，20，22： | 1 |
| 17 | Rat bone marrow stromal cell osteogenic differentiation and fibronectin adsorption on chitosan membranes: The effect of the degree of acetylation显示文摘 | Amaral IF Lamghari M Sousa SR | 2005 | J Biomed Mater Res A2005，75，2： | 1 |
| 18 | Distribution of naturally occurring radionuclides (U, Th) in Timahdit black shale (Morocco)显示文摘 | C. Galindo L. Mougin S. Fakhi A. Nourreddine A. Lamghari H. Hannache | 2006 | Journal of Environmental Radioactivity2006，，1： | 1 |
| 19 | Bone reactions to nacre injected percutaneously into the vertebrae of sheep 显示文摘 | Lamghari M Berland S Laurent A | 2001 | Biomaterials2001，22，6： | 1 |
| 20 | A diversified Tabu search approach for the open-pit mine production scheduling problem with metal uncertainty 显示文摘 | LAMGHARI A DIMITRAKOPOULOS R | 2012 | European Journal of Operational Research2012，222，3： | 1 |
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