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| 1 | Household air pollution and lung cancer in China:a review of studies in Xuanwei显示文摘Over half of the world's population is exposed to household air pollution from the burning of solid fuels at home. Household air pollution from solid fuel use is a leading risk factor for global disease and remains a major public health problem, especially in low- and mid-income countries. This is a particularly serious problem in China, where many people in rural areas still use coal for household heating and cooking. This review focuses on several decades of research carried out in Xuanwei County, Yunnan Province, where household coal use is a major source of household air pollution and where studies have linked household air pollution exposure to high rates of lung cancer. We conducted a series of case-control and cohort studies in Xuanwei to characterize the lung cancer risk in this population and the factors associated with it. We found lung cancer risk to vary substantially between different coal types, with a higher risk associated with smoky(i.e., bituminous) coal use compared to smokeless(i.e., anthracite) coal use. The installation of a chimney in homes resulted in a substantial reduction in lung cancer incidence and mortality. Overall, our research underscores the need among existing coal users to improve ventilation, use the least toxic fuel, and eventually move toward the use of cleaner fuels, such as gas and electricity. | Wei Jie Seow Wei Hu Roel Vermeulen H.Dean Hosgood III George S.Downward Robert S.Chapman Xingzhou He Bryan A.Bassig Christopher Kim Cuiju Wen Nathaniel Rothman Qing Lan | 2014 | Chinese Journal of Cancer2014，33，10： | 15 |
| 2 | Live cell screening platform identifies PPAR6 as a regulator of cardiomyocyte proliferation and cardiac repair显示文摘Zebrafish 能高效地通过 cardiomyocyte 增长改革他们的心。相反,哺乳动物的 cardiomyocytes 站立即在出生以后增殖,限制出生后的哺乳动物的心的再生能力。因此,如果出生后的 cardiomyocyte 增长的内长的潜力能被提高,它能为心失败病人提供有希望的未来治疗。这里,我们开始系统地识别触发出生后的 cardiomyocyte 增长的小分子。由屏蔽为估计房间周期阶段利用一个基于 Fucci 的系统的化学复合图书馆,我们作为出生后的 cardiomyocyte 增长的 inducer 识别了 carbacyclin。在 vitro, carbacyclin 经由 peroxisome 导致了新生、成年的 mononuclear 老鼠 cardiomyocytes 的增长激活 proliferator 的受体(PPAR )/PDK1/p308Akt/GSK3/-catenin 小径。PPAR 的抑制在 zebrafish 心新生期间减少了 cardiomyocyte 增长。尤其是,象有在在老鼠的心肌的梗塞以后的 PPAR 收缩筋的治疗一样的组成地活跃的 PPAR 的可诱导的 cardiomyocyte 特定的 overexpression 在 cardiomyocytes 导致了房间周期前进,减少了结疤,并且改进了心脏的功能。一起,我们建立了屏蔽系统和礼品的 cardiomyocyte 增长有为心脏的病理的治疗的诺言的一个新 drugable 目标由 cardiomyocyte 损失引起了。 | Ajit Magadum Yishu Ding Lan He Teayoun Kim Mohankrishna Dalvoy Vasudevarao Qinqiang Long Kevin Yang Nadeera Wickramasinghe Harsha V Renikunta Nicole Dubois Gilbert Weidinger Qinglin Yang Felix B Engel | 2017 | Cell Research2017，27，8： | 6 |
| 3 | Prognostic implication of isolated tumor cells and micrometastases in regional lymph nodes of gastric cancer显示文摘AIM: To determine the prognostic significance of isolated tumor cells (ITCs) and lymph node micrometastases in gastric cancer.METHODS: Hematoxylin and eosin-stained slides of lymph node dissections of 632 consecutive gastric cancers were reviewed. Cytokeratin immunostaining was performed in 280 node-negative cases and 5 cases indefinite for lymph node metastases. Lymph node metastases were divided into ITC s, micrometastases, or macrometastases, according to the sizes of tumor deposits in largest dimension. ITCs were further classified into four groups according to metastasis pattern.RESULTS: Lymph node metastases were identified by immunostaining in 58 of 280 node-negative cases (20.7%)and were not significantly associated with patient survival (P = 0.3460). After cytokeratin immunostaining, 196 cases were classified as pN1, which consisted of 20 cases with micrometastases detected by immunostaining (pN1mi(i+)),34 cases with only micrometastases (pN1mi), and 142 cases with pN1 with one or more macrometastases (pN1).Cases with pN1mi and pN1mi(i+) had a significantly better prognosis than the cases with pN1 (P = 0.0037). ITCs were found in 38 of these 58 cases, and could be divided into four groups: 12 cases with only a single cell pattern,7 cases with multiple individual cells, 5 cases with single small cluster, and 14 cases with multiple small clusters.Among these four groups, cases with ITCs of multiple individual cell pattern showed the worst survival (median survival: 28 mo, P<0.0001).CONCLUSION: Both size and pattern of lymph node metastases can give prognostic information on the survival of gastric cancer patients. | Hye Seung Lee Min A Kim Han-Kwang Yang Byung Lan Lee Woo Ho Kim | 2005 | World Journal of Gastroenterology2005，11，38： | 5 |
| 4 | HER2-induced metastasis is mediated by AKT/JNK/EMT signaling pathway in gastric cancer显示文摘AIM To investigated the relationships between HER2, c-Jun N-terminal kinase(JNK) and protein kinase B(AKT) with respect to metastatic potential of HER2-positive gastric cancer(GC) cells.METHODS Immunohistochemistry was performed on tissue array slides containing 423 human GC specimens. Using HER2-positve GC cell lines SNU-216 and NCI-N87, HER2 expression was silenced by RNA interference, and the activations of JNK and AKT were suppressed by SP600125 and LY294002, respectively. Transwell assay, Western blot, semi-quantitative reverse transcriptionpolymerase chain reaction and immunofluorescence staining were used in cell culture experiments. RESULTS In GC specimens, HER2, JNK, and AKT activations were positively correlated with each other. In vitro analysis revealed a positive regulatory feedback loop between HER2 and JNK in GC cell lines and the role of JNK as a downstream effector of AKT in the HER2/AKT signaling pathway. JNK inhibition suppressed migratory capacity through reversing EMT and dual inhibition of JNK and AKT induced a more profound effect on cancer cell motility.CONCLUSION HER2, JNK and AKT in human GC specimens are positively associated with each other. JNK and AKT, downstream effectors of HER2, co-operatively contribute to the metastatic potential of HER2-positive GC cells. Thus, targeting of these two molecules in combination with HER2 downregulation may be a good approach to combat HER2-positive GC. | Yiseul Choi Young San Ko Jinju Park Youngsun Choi Younghoon Kim Jung-Soo Pyo Bo Gun Jang Douk Ho Hwang Woo Ho Kim Byung Lan Lee | 2016 | World Journal of Gastroenterology2016，22，41： | 4 |
| 5 | Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism显示文摘 | Marilda Mazzali Jeremy Hughes Yoon-Goo Kim J. Ashley Jefferson Duk-Hee Kang Katherine L. Gordon Hui Y. Lan Salah Kivlighn Richard J. Johnson | 2001 | Hypertension: Journal of the American Heart Association2001，，5： | 2 |
| 6 | Caveolin 1 Expression Correlates with Poor Prognosis and Focal Adhesion Kinase Expression in Gastric Cancer显示文摘 | Nam Kyung Han Lee Byung Lan Park Joo Hyun Kim Jin Han Nayoung Lee Hee Eun Kim Min A Lee Hye Seung Kim Woo Ho | 2012 | Pathobiology2012，，2： | 2 |
| 7 | Thermal analysis of LED array system with heat pipe 显示文摘 | Lan Kim Jong Hwa Choi | 2007 | Thermochimica Acta2007，，455： | 1 |
| 8 | Equivalent linearization of a friction damper–brace system based on the probability distribution of the extremal displacement显示文摘 | Ji-Hun Park Kyung-Won Min Lan Chung Sung-Kyung Lee Hyoung-Seop Kim Byoung-Wook Moon | 2006 | Engineering Structures2006，，6： | 1 |
| 9 | Prediction of cognitive dysfunction and patients’ outcome following valvular heart surgery and the role of cerebral oximetry显示文摘 | Seong Wook Hong Jae Kwang Shim Yong Seon Choi Dae Hee Kim Byung Chul Chang Young Lan Kwak | 2008 | European Journal of Cardio-Thoracic Surgery2008，，4： | 1 |
| 10 | Thermal analysis of LED array system with heat pipe显示文摘 | Lan Kim Jong Hwa Choi Sun Ho Jang | 2007 | Thermo-Chimica Acta2007，455，12： | 1 |
| 11 | Donor Morbidity After Living Donation for Liver Transplantation显示文摘 | Rafik M. Ghobrial Chris E. Freise James F. Trotter Lan Tong Akinlolu O. Ojo Jeffrey H. Fair Robert A. Fisher Jean C. Emond Alan J. Koffron Timothy L. Pruett Kim M. Olthoff | 2008 | Gastroenterology2008，，2： | 1 |
| 12 | Evidence that humans metabolize benzene via two pathways 显示文摘 | Rappaport SM Kim S Lan Q | 2009 | Environ Health Perspect2009，117，6： | 1 |
| 13 | Thermal analysis of LED array system with heat pipe显示文摘 | Kim Lan Choi Jong Hwa Jang Sun Ho | 2007 | Thermochimica acta2007，455，1： | 1 |
| 14 | Genetic polymorphisms and benzene metabolism in humans exposed to a wide range of air con- centrations显示文摘 | KIM S LAN Q WAIDYANATHA S | 2007 | Pharmacogenet Genomics2007，17，10： | 1 |
| 15 | Characterization of the piRNA Complex from Rat Testes显示文摘 | Lan N C Seto A G Kim J | 2006 | Science2006，313，5785： | 1 |
| 16 | Donor Morbidity After Living Donation for Liver Transplantation显示文摘 | Rafik M. Ghobrial Chris E. Freise James F. Trotter Lan Tong Akinlolu O. Ojo Jeffrey H. Fair Robert A. Fisher Jean C. Emond Alan J. Koffron Timothy L. Pruett Kim M. Olthoff | 2008 | Gastroenterology2008，，2： | 1 |
| 17 | 查看详情显示文摘 | Sakthivel A Huang S J Chen W H Lan Z H Chen K H Kim T W Ryoo R Chiang A S T Liu S B | | 0，，： | 1 |
| 18 | ANTIOXIDANT POTENTIAL AND OXIDATIVE DNA DAMAGE PREVENTIVE ACTIVITY OF CHRYSANTHEMUM INDICUM EXTRACTS显示文摘 | TRISHNA DEBNATH HAI LAN JIN MD ABUL HASNAT YUNSUK KIM NADIRA BINTE SAMAD PYO‐JAM PARK BEONG OU LIM | 2013 | Journal of Food Biochemistry2013，，4： | 1 |
| 19 | Incidence, Risk Factors and Clinical Course of Pancreatic Fluid Collections in Acute Pancreatitis显示文摘 | Mei Lan Cui Kook Hyun Kim Ho Gak Kim Jimin Han Hyunsoo Kim Kwang Bum Cho Min Kyu Jung Chang Min Cho Tae Nyeun Kim | 2014 | Digestive Diseases and Sciences2014，，5： | 1 |
| 20 | A protein phosphorylation/dephosphorylation network regulates a plant potassium channel 显示文摘 | LEE S C LAN W Z KIM B G | 2007 | Proc Natl Acad Sci USA2007，104，15： | 1 |
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